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Liu N1, Wang L2, Yang T3, Xiong C4, Xu L2, Shi Y2, Bao W2, Chin YE5, Cheng SB6, Yan H2, Qiu A7, Zhuang S8.
Journal of the American Society of Nephrology : JASN.J Am Soc Nephrol.2015 Nov;26(11):2716-29. doi: 10.1681/ASN.2014080793. Epub 2015 Mar 18.
Hyperuricemia is an independent risk factor for CKD and contributes to kidney fibrosis. In this study, we investigated the effect of EGF receptor (EGFR) inhibition on the development of hyperuricemic nephropathy (HN) and the mechanisms involved. In a rat model of HN induced by feeding a mixture of a
PMID 25788532

Effect of Urate Lowering Therapy on Renal Disease Progression in Hyperuricemic Patients with Chronic Kidney Disease.

Kim Y1, Shin S1, Kim K1, Choi S1, Lee K2.
The Journal of rheumatology.J Rheumatol.2015 Nov;42(11):2143-8. doi: 10.3899/jrheum.150067. Epub 2015 Oct 1.
OBJECTIVE: To determine whether urate lowering therapy (ULT) could delay renal disease progression in hyperuricemic patients with chronic kidney disease (CKD).METHODS: We performed a retrospective review of hyperuricemic patients with stage 3 CKD followed from September 2005 to July 2014 in Dongguk
PMID 26428209

Effects of losartan on expression of monocyte chemoattractant protein-1 (MCP-1) in hyperuricemic nephropathy rats.

Yu S1,2, Ren Q3, Wu W2.
Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2015 Oct;35(5):458-61. doi: 10.3109/10799893.2015.1006332. Epub 2015 Apr 1.
The monocyte chemoattractant protein-1 (MCP-1) plays an important role in the pathogenesis of progression of renal failure. This is based on the observations done both in various animal models of renal damage and in different types of human renal disease. During the development of non-infectious kid
PMID 25830624

A Novel UMOD Gene Mutation Associated with Uromodulin-associated Kidney Disease in a Young Woman with Moderate Kidney Dysfunction

, , , , , , , , , , ,
Internal Medicine 54(6), 631-635, 2015
Uromodulin-associated kidney disease (UAKD) is an autosomal dominant disease caused by a mutation in the uromodulin (UMOD) gene, leading to end-stage renal disease. We herein report the case of a fami …
NAID 130004903078

Topiroxostat improved the apoptosis of cells expressing Uromodulin Mutation C112Y Causing Familial Juvenile Hyperuricemic Nephropathy (FJHN)

A Novel Uromodulin Mutation C112Y Causing Familial Juvenile Hyperuricemic Nephropathy (FJHN) : Hsp70 Rescued the Cellular Apoptosis due to Its Protein Instability

英: gouty nephropathy, gouty kidney
同: 尿酸塩腎症 urate nephropathy、高尿酸血性腎症 hyperuricemic nephropathy、痛風性腎症、尿酸性腎症 uric acid nephropathy
関: 高尿酸血症

高尿酸血症による腎障害
尿細管障害をきたす。
病理的には間質に尿酸や尿酸一ナトリウム塩の結晶の存在が確認される。これにより間質の閉塞だけでなく炎症反応を惹起する。リンパ球の浸潤、foreign-body giant cell reaction、ついには線維化をきたす。これは腎髄質や腎乳頭で著明である。 (HIM.1809)
GFRはほぼ正常。脳濃縮能の低下、(蛋白尿？) (HIM.1809)

リンク元	「痛風腎」
関連記事	「hyperuricemic」