WordNet

look at with fixed eyes; "The students stared at the teacher with amazement" (同)stare
a long fixed look; "he fixed his paternal gaze on me" (同)regard
directed up; "the cards were face upward"; "an upward stroke of the pen"
a condition marked by uncontrollable tremor
affect with palsy
become friends; act friendly towards (同)pal up, chum up

PrepTutorEJDIC

(…を)『じっと見つめる』,凝視する《+『at』(『into,on,upon』)+『名』》 / 『じっと見詰めること』,凝視
『上のほうへ』,上向きに / (地位.階級などが)『上位へ』 / (数量などが)…以上,さらに多く / (…から)以降 / (大都市.水源.内陸)のほうへ / 『上向きの』,上昇する
麻痺(まひ),中風 / …‘を'麻痺させる(paralyze)
《話》『友達』,仲間,親友 / (…と)仲よくなる《[『up』]『with』+『名』》
=upward

UpToDate Contents

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1. 進行性核上性麻痺（PSP） progressive supranuclear palsy psp
2. 小児における核上性注視異常 supranuclear disorders of gaze in children
3. パーキンソン病の臨床症状 clinical manifestations of parkinson disease
4. 単純ヘルペスウイルス1型脳炎 herpes simplex virus type 1 encephalitis
5. 成人における詳細な神経学的検査 the detailed neurologic examination in adults

English Journal

Niemann-Pick disease type C symptomatology: an expert-based clinical description.

Mengel E, Klünemann HH, Lourenço CM, Hendriksz CJ, Sedel F, Walterfang M, Kolb SA.AbstractNiemann-Pick disease type C (NP-C) is a rare, progressive, irreversible disease leading to disabling neurological manifestations and premature death. The estimated disease incidence is 1:120,000 live births, but this likely represents an underestimate, as the disease may be under-diagnosed due to its highly heterogeneous presentation. NP-C is characterised by visceral, neurological and psychiatric manifestations that are not specific to the disease and that can be found in other conditions. The aim of this review is to provide non-specialists with an expert-based, detailed description of NP-C signs and symptoms, including how they present in patients and how they can be assessed. Early disease detection should rely on seeking a combination of signs and symptoms, rather than isolated findings. Examples of combinations which are strongly suggestive of NP-C include: splenomegaly and vertical supranuclear gaze palsy (VSGP); splenomegaly and clumsiness; splenomegaly and schizophrenia-like psychosis; psychotic symptoms and cognitive decline; and ataxia with dystonia, dysarthria/dysphagia and cognitive decline. VSGP is a hallmark of NP-C and becomes highly specific of the disease when it occurs in combination with other manifestations (e.g. splenomegaly, ataxia). In young infants (<2 years), abnormal saccades may first manifest as slowing and shortening of upward saccades, long before gaze palsy onset. While visceral manifestations tend to predominate during the perinatal and infantile period (2 months--6 years of age), neurological and psychiatric involvement is more prominent during the juvenile/adult period (>6 years of age). Psychosis in NP-C is atypical and variably responsive to treatment. Progressive cognitive decline, which always occurs in patients with NP-C, manifests as memory and executive impairment in juvenile/adult patients. Disease prognosis mainly correlates with the age at onset of the neurological signs, with early-onset forms progressing faster. Therefore, a detailed and descriptive picture of NP-C signs and symptoms may help improve disease detection and early diagnosis, so that therapy with miglustat (Zavesca(R)), the only available treatment approved to date, can be started as soon as neurological symptoms appear, in order to slow disease progression.
Orphanet journal of rare diseases.Orphanet J Rare Dis.2013 Oct 17;8(1):166. [Epub ahead of print]
Niemann-Pick disease type C (NP-C) is a rare, progressive, irreversible disease leading to disabling neurological manifestations and premature death. The estimated disease incidence is 1:120,000 live births, but this likely represents an underestimate, as the disease may be under-diagnosed due to it
PMID 24135395

Ophthalmological outcome after resection of tumors based on the pineal gland.

Hart MG, Sarkies NJ, Santarius T, Kirollos RW.SourceDepartment of Neurosurgery, Addenbrooke’s Hospital, Cambridge, United Kingdom. mikehart82@me.com
Journal of neurosurgery.J Neurosurg.2013 Aug;119(2):420-6. doi: 10.3171/2013.3.JNS122137. Epub 2013 May 10.
OBJECT: Descriptions of visual dysfunction in pineal gland tumors tend to focus on upward gaze palsy alone. The authors aimed to characterize the nature, incidence, and functional significance of ophthalmological dysfunction after resection of tumors based on the pineal gland.METHODS: Review of a re
PMID 23662830

Japanese Journal

Myasthenia Gravis Mimicking Upward Gaze Palsy Without Pupillary and Palpebral Involvement

WU Horng-Jiun,TSAI Rong-Kung
Japanese journal of ophthalmology 49(2), 181-182, 2005-03-01
NAID 10016485039

Isolated Third and Fourth Ventricles Associated With Neurosarcoidosis Successfully Treated by Neuroendoscopy : Case Report

HAMADA Hideo,HAYASHI Nakamasa,KURIMOTO Masanori,UMEMURA Kimiko,HlRASHIMA Yutaka,ENDO Shunro
Neurologia medico-chirurgica 44(8), 435-437, 2004-08-15
… A 48-year-old woman presented with a unique case of isolated third and fourth ventricles associated with neurosarcoidosis, manifesting as upward gaze palsy. … Postoperatively the size of the third and fourth ventricles was reduced, and the upward gaze palsy resolved. …
NAID 110002277244