腫瘍抑制タンパク質p14ARF
WordNet
- to put down by force or authority; "suppress a nascent uprising"; "stamp down on littering"; "conquer ones desires" (同)stamp down, inhibit, subdue, conquer, curb
- reduce the incidence or severity of or stop; "suppress a yawn"; "this drug can suppress the hemorrhage"
- put out of ones consciousness (同)repress
- an electrical device for suppressing unwanted currents (同)suppresser
- someone who suppresses; "dictators are suppressors of free speech" (同)suppresser
- a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene) (同)suppresser, suppressor_gene, suppresser gene
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
PrepTutorEJDIC
- 〈反乱など〉‘を'『鎮圧する』…,‘の'活動を押える / 〈感情・欲望など〉‘を'『抑制する』,抑える / …‘の'発表を禁止する,伏せる
- 抑圧する人,鎮圧者 / (ラジオ・テレビの)妨害電波(混信)防止装置
- 蛋白(たんばく)質
UpToDate Contents
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English Journal
- Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF.
- Diaz-Rodriguez E1, Garcia-Rendueles AR, Ibáñez-Costa A, Gutierrez-Pascual E, Garcia-Lavandeira M, Leal A, Japon MA, Soto A, Venegas E, Tinahones FJ, Garcia-Arnes JA, Benito P, Angeles Galvez M, Jimenez-Reina L, Bernabeu I, Dieguez C, Luque RM, Castaño JP, Alvarez CV.
- Endocrinology.Endocrinology.2014 Nov;155(11):4329-40. doi: 10.1210/en.2014-1034. Epub 2014 Aug 19.
- Acromegaly is caused by somatotroph cell adenomas (somatotropinomas [ACROs]), which secrete GH. Human and rodent somatotroph cells express the RET receptor. In rodents, when normal somatotrophs are deprived of the RET ligand, GDNF (Glial Cell Derived Neurotrophic Factor), RET is processed intracellu
- PMID 25137025
- [p14ARF enhances chemosensitivity to cisplatin in human osteosarcoma U2OS cells through p53 apoptotic pathway].
- Yuan X1, Huang X, Chen Z, Liang S, Liao W.
- Zhonghua yi xue za zhi.Zhonghua Yi Xue Za Zhi.2014 Nov;94(43):3443-6.
- OBJECTIVE: To explore the effects of tumor suppressor p14ARF on chemosensitivity of human osteosarcoma U2OS cells to cisplatin and elucidate its molecular mechanism.METHODS: U2OS cells expressing no p14ARF and U2OS-ARF cells expressing p14ARF stably through stable transfection were treated with cisp
- PMID 25622680
- Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs.
- Kurayoshi K1, Ozono E2, Iwanaga R3, Bradford AP3, Komori H4, Ohtani K5.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Jul 18;450(1):240-6. doi: 10.1016/j.bbrc.2014.05.102. Epub 2014 Jun 2.
- In current cancer treatment protocols, such as radiation and chemotherapy, side effects on normal cells are major obstacles to radical therapy. To avoid these side effects, a cancer cell-specific approach is needed. One way to specifically target cancer cells is to utilize a cancer specific promoter
- PMID 24893334
Japanese Journal
- The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-lalpha (HIF-1alpha) and inhibits HIF-1-mediated transcription
Related Links
- tumor suppressor gene n. Any of various genes that normally suppress cellular proliferation and that, when mutated, are associated with the development of certain cancers, including many familial cancers. Also called antioncogene. ...
- 1. J Invest Dermatol. 2004 May;122(5):1284-92. p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma. Brown VL(1), Harwood CA, Crook T, Cronin JG, Kelsell ...
★リンクテーブル★
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- 英
- tumor suppressor protein p14ARF
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- 関
- abrogate、abrogation、arrest、curb、depress、depression、inhibit、inhibition、restrain、restraint、subdue、suppression
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- 関
- inhibitory factor、repressor
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