同: TnT

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the 20th letter of the Roman alphabet (同)t
a tough youth of 1950s and 1960s wearing Edwardian style clothes (同)Teddy boy

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tritiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/14 02:59:19」(JST)

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Troponin

Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex.

The tissue specific subtypes are:

Slow skeletal troponin T1, TNNT1 (19q13.4, 191041)
Cardiac troponin T2, TNNT2 (1q32, 191045)
Fast skeletal troponin T3, TNNT3 (11p15.5, 600692)

Troponin T binds to tropomyosin and helps position it on actin.^[1] And in a less complicated light, Troponin T modulates contraction of striated muscle ^[2]

Troponin T was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He developed the troponin T assay.^[3]

In patients with stable coronary artery disease, troponin T concentrations have been found to be significantly associated with the incidence of cardiovascular death and heart failure, but not with myocardial infarction.^[4]

References

^ marieb, elaine (2004)
^ black, joyce (2005)
^ "Development of the Cardiac Troponin T Immunoassay". American Association for Clinical Chemistry, Inc. 2008. Retrieved 2010-05-01.
^ "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease". New England Journal of Medicine. 2009. Retrieved 2012-04-04.

External links

Troponin T at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. Troponins as biomarkers of cardiac injury
2. 急性冠症候群がない患者にでの心筋トロポニン濃度の上昇 elevated cardiac troponin concentration in the absence of an acute coronary syndrome
3. Biomarkers suggesting cardiac injury other than troponins
4. 腎不全患者における血清心臓バイオマーカー serum cardiac biomarkers in patients with renal failure
5. 周産期心筋症：治療および予後 peripartum cardiomyopathy treatment and prognosis

English Journal

High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain.

Eggers KM, Venge P, Lindahl B.SourceDepartment of Medical Sciences, Cardiology, Uppsala University, Sweden.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2012 Jul 11;413(13-14):1135-40. Epub 2012 Mar 19.
BACKGROUND: Measurement of high-sensitive cardiac troponin (hs-cTn) has facilitated the early diagnostic assessment of chest pain patients. However, the information obtained from hs-cTnT levels might be improved when combined with results of other biomarkers of myocardial injury.METHODS: We measured
PMID 22456003

Cardiac troponin T levels and exercise stress testing in patients with suspected coronary artery disease: the Akershus Cardiac Examination (ACE) 1 study.

Røysland R, Kravdal G, Høiseth AD, Nygård S, Badr P, Hagve TA, Omland T, Røsjø H.SourceDivision of Medicine, Akershus University Hospital, 1478 Lørenskog, Norway.
Clinical science (London, England : 1979).Clin Sci (Lond).2012 Jun;122(12):599-606.
Whether reversible ischaemia in patients referred for exercise stress testing and MPI (myocardial perfusion imaging) is associated with changes in circulating cTn (cardiac troponin) levels is controversial. We measured cTnT with a sensitive assay before, immediately after peak exercise and 1.5 and 4
PMID 22239123