トロポニンT

WordNet

the 20th letter of the Roman alphabet (同)t
explosive consisting of a yellow crystalline compound that is a flammable toxic derivative of toluene (同)trinitrotoluene

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トリニトロトルエン,高性能爆薬(《略》TNT,T.N.T.)
tritiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/02 04:58:03」(JST)

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Troponin

Troponin T is a skeletal and smooth muscle protein useful in laboratory diagnosis of heart attack, as it is released into the blood stream when damage to the heart muscle occurs.^[1] It is is a part of the troponin complex, where it binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex.

The tissue-specific subtypes are:

Slow skeletal troponin T1, TNNT1 (19q13.4, 191041)
Cardiac troponin T2, TNNT2 (1q32, 191045)
Fast skeletal troponin T3, TNNT3 (11p15.5, 600692)

Troponin T binds to tropomyosin and helps position it on actin,^[2] and with the rest of the troponin complex modulates contraction of striated muscle.^[3]

Troponin T was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He also developed the troponin T assay.^[4]

In patients with stable coronary artery disease, troponin T concentrations have long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted in predicting who would later suffer acute myocardial infarction (heart attack).^[5]^[6] A study at the Swedish Karolinska Institute, not yet formally reported in a journal, showed that high-sensitivity cardiac troponin T did have some predictive power in telling which patients with chest pain would be at risk.

Reference Values

The upper limit of Troponin T for normal individuals is <0.015 ng/mL. Values > or =0.015 ng/mL have been shown to have prognostic value. Increased troponin T levels after an episode of chest pain mean that a heart attack has occurred.^[7]

References

^ https://medlineplus.gov/ency/article/007452.htm. Missing or empty |title= (help)
^ marieb, elaine (2004)
^ black, joyce (2005)
^ "Development of the Cardiac Troponin T Immunoassay". American Association for Clinical Chemistry, Inc. 2008. Retrieved 2010-05-01.
^ "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease". New England Journal of Medicine. 2009. Retrieved 2012-04-04.
^ http://healthyliving.msn.com/diseases/heart-and-cardiovascular/blood-test-shows-promise-for-gauging-heart-attack-risk-after-chest-pain
^ https://medlineplus.gov/ency/article/007452.htm. Missing or empty |title= (help)

External links

Troponin T at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Photoluminescence detection of 2,4,6-trinitrotoluene (TNT) binding on diatom frustule biosilica functionalized with an anti-TNT monoclonal antibody fragment.

Zhen L1, Ford N2, Gale DK1, Roesijadi G3, Rorrer GL4.
Biosensors & bioelectronics.Biosens Bioelectron.2016 May 15;79:742-8. doi: 10.1016/j.bios.2016.01.002. Epub 2016 Jan 4.
A selective and label-free biosensor for detection of the explosive compound 2,4,6-trinitrotoluene (TNT) in aqueous solution was developed based on the principle of photoluminescence quenching of upon immunocomplex formation with antibody-functionalized diatom frustule biosilica. The diatom frustule
PMID 26774089

TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.

Wei B1, Jin JP2.
Gene.Gene.2016 May 10;582(1):1-13. doi: 10.1016/j.gene.2016.01.006. Epub 2016 Jan 13.
Troponin T (TnT) is a central player in the calcium regulation of actin thin filament function and is essential for the contraction of striated muscles. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for
PMID 26774798

Numerical analysis of thermal decomposition for RDX, TNT, and Composition B.

Kim SH1, Nyande BW1, Kim HS2, Park JS2, Lee WJ3, Oh M4.
Journal of hazardous materials.J Hazard Mater.2016 May 5;308:120-30. doi: 10.1016/j.jhazmat.2015.12.061. Epub 2016 Jan 6.
Demilitarization of waste explosives on a commercial scale has become an important issue in many countries, and this has created a need for research in this area. TNT, RDX and Composition B have been used as military explosives, and they are very sensitive to thermal shock. For the safe waste treatm
PMID 26808250