sporadic Creutzfeldt- Jakob disease

孤発性クロイツフェルト・ヤコブ病

WordNet

1. an impairment of health or a condition of abnormal functioning
2. recurring in scattered and irregular or unpredictable instances; "a city subjected to sporadic bombing raids"
3. caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

PrepTutorEJDIC

1. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
2. 女性の話術芸人 =diseur
3. ときどき起こる; / 散在する / (病気が伝染性でなく)散発の,特発性の
4. 病気にかかった / 病的な,不健全な(morbid)

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• 1. クロイツフェルト・ヤコブ病 creutzfeldt jakob disease
• 2. 変異型クロイツフェルト・ヤコブ病 variant creutzfeldt jakob disease
• 3. プリオンによる中枢神経系疾患 diseases of the central nervous system caused by prions
• 4. 成人における小脳性運動失調の概要 overview of cerebellar ataxia in adults
• 5. プリオンの生物学および遺伝学 biology and genetics of prions

English Journal

• Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson's disease.

• Singh N1, Haldar S, Tripathi AK, McElwee MK, Horback K, Beserra A.
• Antioxidants & redox signaling.Antioxid Redox Signal.2014 Jul 20;21(3):471-84. doi: 10.1089/ars.2014.5874. Epub 2014 Feb 27.
• Abstract Significance: Intracellular and extracellular aggregation of a specific protein or protein fragments is the principal pathological event in several neurodegenerative conditions. We describe two such conditions: sporadic Creutzfeldt-Jakob disease (sCJD), a rare but potentially infectious and
• PMID 24512387

• Extensive cortical spongiform changes with cerebellar small amyloid plaques: The clinicopathological case of MV2K+C subtype in Creutzfeldt-Jakob disease.

• Araki K1, Nakano Y, Kobayashi A, Matsudaira T, Sugiura A, Takao M, Kitamoto T, Murayama S, Obi T.
• Neuropathology : official journal of the Japanese Society of Neuropathology.Neuropathology.2014 Jul 2. doi: 10.1111/neup.12133. [Epub ahead of print]
• We report a clinical case report of the MV2K+C subtype of sporadic Creutzfeldt-Jakob disease (sCJD). The patient was a 72-year-old woman who exhibited progressive dementia over the course of 22 months. Diffusion-weighted MRI during this period showed abnormal hyperintensity in the cerebral cortex in
• PMID 24984899

• Complex proteinopathy with accumulations of prion protein, hyperphosphorylated tau, α-synuclein and ubiquitin in experimental bovine spongiform encephalopathy of monkeys.

• Piccardo P1, Cervenak J2, Bu M2, Miller L2, Asher DM2.
• The Journal of general virology.J Gen Virol.2014 Jul;95(Pt 7):1612-8. doi: 10.1099/vir.0.062083-0. Epub 2014 Apr 25.
• Proteins aggregate in several slowly progressive neurodegenerative diseases called 'proteinopathies'. Studies with cell cultures and transgenic mice overexpressing mutated proteins suggested that aggregates of one protein induced misfolding and aggregation of other proteins as well - a possible comm
• PMID 24769839

Japanese Journal

• Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene

• Qina Temu,Sanjo Nobuo,Hizume Masaki,Higuma Maya,Tomita Makoto,Atarashi Ryuichiro,Satoh Katsuya,Nozaki Ichiro,Hamaguchi Tsuyoshi,Nakamura Yosikazu,Kobayashi Atsushi,Kitamoto Tetsuyuki,Murayama Shigeo,Murai Hiroyuki,Yamada Masahito,Mizusawa Hidehiro
• BMJ Open 4(5), e004968, 2014-05-16
• … Objectives: Genetic Creutzfeldt-Jakob disease (CJD) due to V180I mutation in the prion protein gene (PRNP) is of great interest because of the differences from sporadic CJD and other genetic prion diseases in terms of clinical features, as well as pathological and biochemical findings. …
• NAID 120005451799

• Creutzfeldt-Jakob Disease with a Codon 210 Mutation: First Pathological Observation in a Japanese Patient

• Tajima Yasutaka,Satoh Chika,Mito Yasunori,Kitamoto Tetsuyuki
• Internal Medicine 53(5), 483-487, 2014
• … We herein report a case of Creutzfeldt-Jakob disease (CJD) with a V210I mutation and discuss the pathological findings. … The patient's clinical course was quite similar to that of patients with sporadic CJD. …
• NAID 130003392674

• Early Detection of Abnormal Prion Protein in Genetic Human Prion Diseases Now Possible Using Real-Time QUIC Assay

• Sano Kazunori,Satoh Katsuya,Atarashi Ryuichiro,Takashima Hiroshi,Iwasaki Yasushi,Yoshida Mari,Sanjo Nobuo,Murai Hiroyuki,Mizusawa Hidehiro,Schmitz Matthias,Zerr Inga,Kim Yong-Sun,Nishida Noriyuki
• PLoS ONE 8(1), e54915, 2013-01-25
• … We recently developed a new in vitro amplification technology, designated "real-time quaking-induced conversion (RT-QUIC)", to detect the abnormal form of prion protein in CSF from sporadic Creutzfeldt-Jakob disease (sCJD) patients. …
• NAID 120005230763

Related Links

• CREUTZFELDT JAKOB DISEASE

CREUTZFELDT JAKOB DISEASE SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM 1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype of 'UNKNOWN ... Two Vietnamese men have ...

• Creutzfeldt-Jakob Disease Fact Sheet: National Institute of ...

In sporadic CJD, the disease appears even though the person has no known risk factors for the disease. This is by far the most common type of CJD and accounts for at least 85 percent of cases. In hereditary CJD, the person ...

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★リンクテーブル★

リンク元	「孤発性クロイツフェルト・ヤコブ病」
関連記事	「disease」「sporadic」「Jakob」

「孤発性クロイツフェルト・ヤコブ病」

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英

sporadic Creutzfeldt- Jakob disease, sCJD

同

孤発性Creutzfeldt-Jakob病

関

クロイツフェルト・ヤコブ病

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「sporadic」

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• adj.

• 散発的な、時々起こる、散発性の、散在する、散在性の、散在的な
• 孤発性の

　 　

「Jakob」

　　[★]

ヤコブ

• Creutzfeldt-Jakob disease