specific monoclonal antibody

• 特異的モノクローナル抗体

WordNet

1. stated explicitly or in detail; "needed a specific amount"
2. a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"
3. (sometimes followed by `to'
4. being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"
5. relating to or distinguishing or constituting a taxonomic species; "specific characters"
6. any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
7. forming or derived from a single clone

PrepTutorEJDIC

1. 《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)
2. 抗体,免疫体,抗毒素

UpToDate Contents

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• 1. 癌治療に用いられる治療用モノクローナル抗体に対する輸注反応 infusion reactions to therapeutic monoclonal antibodies used for cancer therapy
• 2. 生物学的療法により誘発された二次性免疫不全症 secondary immunodeficiency induced by biologic therapies
• 3. 腫瘍壊死因子α（TNF-α）阻害剤：副作用の概要 tumor necrosis factor alpha inhibitors an overview of adverse effects
• 4. 成人における肝移植：免疫抑制の概要 liver transplantation in adults overview of immunosuppression
• 5. 免疫グロブリンの機能および臨床応用 function and clinical applications of immunoglobulins

English Journal

• A monoclonal antibody-based enzyme-linked immunosorbent assay for detection of ustiloxin A in rice false smut balls and rice samples.

• Fu X1, Wang X1, Cui Y1, Wang A1, Lai D1, Liu Y2, Li QX3, Wang B4, Zhou L5.
• Food chemistry.Food Chem.2015 Aug 15;181:140-5. doi: 10.1016/j.foodchem.2015.02.068. Epub 2015 Feb 21.
• Ustiloxin A, a cyclopeptide mycotoxin, was isolated from the pathogenic fungus Villosiclava virens that causes rice false smut, a worldwide devastating rice disease. A monoclonal antibody (mAb) 2D3G5 was generated with ustiloxin A-bovine serum albumin conjugate. A highly sensitive and specific indir
• PMID 25794732

• Antitumor activity of an anti-CD98 antibody.

• Hayes GM1, Chinn L1, Cantor JM2, Cairns B1, Levashova Z1, Tran H1, Velilla T1, Duey D1, Lippincott J1, Zachwieja J1, Ginsberg MH2, H van der Horst E1.
• International journal of cancer. Journal international du cancer.Int J Cancer.2015 Aug 1;137(3):710-20. doi: 10.1002/ijc.29415. Epub 2015 Jan 14.
• CD98 is expressed on several tissue types and specifically upregulated on fast-cycling cells undergoing clonal expansion. Various solid (e.g., nonsmall cell lung carcinoma) as well as hematological malignancies (e.g., acute myeloid leukemia) overexpress CD98. We have identified a CD98-specific mouse
• PMID 25556716

• Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer.

• Li X1, Sun L1, Hou J1, Gui M1, Ying J2, Zhao H2, Lv N2, Meng S1.
• International journal of cancer. Journal international du cancer.Int J Cancer.2015 Aug 1;137(3):512-24. doi: 10.1002/ijc.29405. Epub 2015 Jan 8.
• HER2 receptor dimerization is a critical step in the HER2 activation process. Here, we demonstrated that heat shock protein gp96 on cell membrane interacts with HER2, facilitates HER2 dimerization and promotes cell proliferation. Cell membrane gp96 levels were observed to correlate with HER2 phospho
• PMID 25546612

Japanese Journal

• Interaction between TIM-1 and NPC1 Is Important for Cellular Entry of Ebola Virus

• Kuroda Makoto,Fujikura Daisuke,Nanbo Asuka,Marzi Andrea,Noyori Osamu,Kajihara Masahiro,Maruyama Junki,Matsuno Keita,Miyamoto Hiroko,Yoshida Reiko,Feldmann Heinz,Takada Ayato
• Journal of virology 89(12), 6481-6493, 2015-06
• … Interestingly, a TIM-1-specific monoclonal antibody (MAb), M224/1, prevented GP-mediated membrane fusion and also interfered with the binding of TIM-1 to NPC1, suggesting that the interaction between TIM-1 and NPC1 is important for filovirus membrane fusion. …
• NAID 120005621883

• Isolation of B subunit-specific monoclonal antibody clones that strongly neutralize the toxicity of Shiga toxin 2

• Arimitsu Hideyuki,Sasaki Keiko,Iba Yoshitaka [他]
• Microbiology and immunology 59(2), 71-81, 2015-02
• NAID 40020388170

• 次世代抗体医薬品の非臨床評価

• 石井 明子,多田 稔,鈴木 琢雄,川崎 ナナ
• 薬学雑誌. 乙号 135(7), 857-866, 2015
• …   Therapeutic monoclonal antibodies (mAbs) exert their effects via binding to specific target molecules, which is expected to show rare off-target adverse reactions. …
• NAID 130005085757

Related Links

• CasMab | 東北大学大学院医学系研究科・加藤研究室

A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin. Sci Rep 4, 5924, doi:10.1038/srep05924 2014/8/1（金） 仙台放送スーパーニュース 2014/8/1（金） Nスタみやぎ 2014/8/1（金） ） ...

• Monoclonal antibodies to treat cancer | American Cancer Society

One way the immune system attacks foreign substances in the body is by making large numbers of antibodies. An antibody is a protein that sticks to a specific protein called an antigen. Antibodies circulate throughout the body until ...

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★リンクテーブル★

リンク元	「特異的モノクローナル抗体」
関連記事	「specific」「monoclonal」

「特異的モノクローナル抗体」

　　[★]

英

specific monoclonal antibody

「specific」

　　[★]

• adj.

• (～に関して)明確な、はっきりとした(exact precise)、具体的な(in, about)
• (比較)(限定)特定の(particular)、一定の(⇔general)
• (～に)特有の、独特の(to)
• (比較)(医学)(～に)渡航のある(for)。特殊な
• (生物)(生物)種の
• 医学)特異の
• (物理)比の。物質固有の。単位質量・長さ・面積・容積で

n.

関

specifically、specificity

　 　 　 　 　 　

「monoclonal」

　　[★]

• adj.

• 単クローンの、モノクローナル

関

monoclonality、monoclone