ソマトメジン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/19 03:11:22」(JST)
[Wiki en表示]
Somatomedins are produced, predominantly by the liver, when growth hormones act on target tissue. Somatomedins inhibit the release of growth hormones by acting directly on anterior pituitary and by stimulating the secretion of somatostatin from the hypothalamus.
Somatomedins are a group of hormones that promote cell growth and division in response to stimulation by growth hormone (GH) also known as somatotropin (STH).[1]
Somatomedins have similar biological effects to somatotropin.
In addition to their actions that stimulate growth, somatomedins also stimulate production of somatostatin, which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have autocrine and paracrine actions in addition to their endocrine action. The liver is thought to be the predominant source of circulating somatomedins.[2]
Three forms include:
- somatomedin A, which is another name for insulin-like growth factor 2 (IGF-2)
- somatomedin B, which is derived from vitronectin[3]
- somatomedin C, which is another name for insulin-like growth factor 1 (IGF-1)
References
- ^ Somatomedin at eMedicine Dictionary
- ^ Berner Levy Physiology 6th edition|page=723|
- ^ Zhou A (2007). "Functional structure of the somatomedin B domain of vitronectin". Protein Science 16 (7): 1502–8. doi:10.1110/ps.072819107. PMC 2206693. PMID 17567740.
External links
- Somatomedins at the US National Library of Medicine Medical Subject Headings (MeSH)
- Brs physiology
Intercellular signaling peptides and proteins / ligands
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Growth factors |
- Endothelial growth factor
- Epidermal growth factor
- Fibroblast growth factor
- Nerve growth factor
- Platelet-derived growth factor
- Transforming growth factor beta superfamily
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Ephrin |
- EFNA1
- EFNA2
- EFNA3
- EFNA4
- EFNA5
- EFNB1
- EFNB2
- EFNB3
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Other |
- Adipokine
- Agouti signaling protein
- Agouti-related protein
- Angiogenic protein
- CCN intercellular signaling protein
- Cysteine-rich protein 61
- Connective tissue growth factor
- Nephroblastoma overexpressed protein
- Cytokine
- Endothelin
- Hedgehog protein
- Interferon
- Kinin
- Parathyroid hormone-related protein
- Semaphorin
- Somatomedin
- Tolloid-like metalloproteinase
- Tumor necrosis factor
- Wnt protein
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see also extracellular ligand disorders
Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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UpToDate Contents
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English Journal
- miR-29, a potential therapeutic target for liver fibrosis.
- Bian EB1, Li J1, Zhao B2.
- Gene.Gene.2014 Jul 10;544(2):259-60. doi: 10.1016/j.gene.2014.04.076. Epub 2014 May 2.
- PMID 24792894
- GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells.
- Li HX1, Zhou YF1, Jiang B1, Zhao X1, Jiang TB1, Li X1, Yang XJ2, Jiang WP1.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jun;1840(6):2060-9. doi: 10.1016/j.bbagen.2014.02.020. Epub 2014 Feb 26.
- BACKGROUND: Transplanted mesenchymal stem cells (MSC) can differentiate into cardiac cells that have the potential to contribute to heart repair following ischemic injury. Overexpression of GATA-4 can significantly increase differentiation of MSC into cardiomyocytes (CM). However, the specific impac
- PMID 24582939
- Epigenetic regulation of the Igf2/H19 gene cluster.
- Nordin M1, Bergman D, Halje M, Engström W, Ward A.
- Cell proliferation.Cell Prolif.2014 Jun;47(3):189-99. doi: 10.1111/cpr.12106. Epub 2014 Apr 16.
- Igf2 (insulin-like growth factor 2) and H19 genes are imprinted in mammals; they are expressed unevenly from the two parental alleles. Igf2 is a growth factor expressed in most normal tissues, solely from the paternal allele. H19 gene is transcribed (but not translated to a protein) from the materna
- PMID 24738971
Japanese Journal
- 先端巨大症に伴う下顎前突症に対して顎矯正手術を施行した1例 : 骨格・咬合・鼻形態の変化
- 嵐山 貴徳,宮城 尚史,福田 純一,齋藤 功,高木 律男
- 日本顎変形症学会雑誌 = The Japanese journal of jaw deformities 21(1), 18-29, 2011-04-15
- … The GH and somatomedin levels were high. … Subsequently, since the GH and somatomedin levels decreased almost to the normal ranges, preoperative orthodontic treatment was initiated, and bilateral sagittal splitting ramus osteotomy was performed 18 months after the tumor resection. …
- NAID 10030789224
- The Relation between Concentric and Eccentric Exercise and the Carbohydrate Metabolism in Healthy Individuals
- バイオフィリア リハビリテーション研究 6(1), 27-34, 2010
- … Venous blood samples were drawn before and immediately after the test, and during 1-hour recovery for the determinations of hormonal and somatomedin concentrations. …
- NAID 130004937787
- The Relation between Concentric and Eccentric Exercise and the Carbohydrate Metabolism in Healthy Individuals
- ZEBROWSKA Aleksandra
- バイオフィリア リハビリテーション研究 6(1), 27-34, 2010
- … Venous blood samples were drawn before and immediately after the test, and during 1-hour recovery for the determinations of hormonal and somatomedin concentrations. …
- NAID 130000657800
Related Links
- SOMATOMEDIN A IGF1R; INSULIN-LIKE GROWTH FACTOR I RECEPTOR キーワード インスリン様成長因子、成長ホルモン、IGFシグナル経路、癌 歴史とあらまし インスリン様成長因子(IGF)は成長ホルモンによる作用を仲介 する ...
- somatomedin [so″mah-to-me´din] any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased ...
Related Pictures
★リンクテーブル★
[★]
- 英
- insulin-like growth factor I insuline-like growth factor-I IGF-I IGF-1
- 同
- インスリン様増殖因子I、インスリン様成長因子I。ソマトメジンC somatomedin C, ソマトメジン somatomedin
分類
性状
産生組織
標的組織
- 血行性にホルモンとして、自己分泌的、傍分泌的に作用。
受容体
作用
- IGF-IはGH依存性に種々の組織で合成、分泌され、主にオートクリン作用によって組織の増殖を促進する。
分泌の調整
分子機構
臨床関連
生合成
[★]
- 英
- somatomedin (PT), SM
- 同
- インスリン様成長因子-I, IGF-I
- 関
- インスリン様成長因子, インスリン様成長因子
- → インスリン様成長因子-I
[★]
- 関
- insulin-like growth factor receptor
[★]
ソマトメジン活性物質