somatic mutation theory

体細胞変異説

WordNet

1. a belief that can guide behavior; "the architect has a theory that more is less"; "they killed him on the theory that dead men tell no tales"
2. a well-substantiated explanation of some aspect of the natural world; an organized system of accepted knowledge that applies in a variety of circumstances to explain a specific set of phenomena; "theories can incorporate facts and laws and tested hypothes
3. (genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism (同)genetic mutation, chromosomal_mutation
4. a change or alteration in form or qualities

PrepTutorEJDIC

1. 〈C〉(…の)(学問的な)『理論』,学説《+of+名》 / 〈C〉〈U〉(…の実地に対する)『理論』《+of+名》 / 〈C〉(…という)『推測』,憶測;見解,孝え《+that節》
2. 変化,俸転 / (生物の)突然変異;その変種
3. 身体の / 体腔(たいこう)の / 体細胞の

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English Journal

• Are GATA1 mutations occurring at random in Down syndrome transient leukemia?

• Satgé D.
• Medical hypotheses.Med Hypotheses.2014 Aug;83(2):154-9. doi: 10.1016/j.mehy.2014.05.005. Epub 2014 May 20.
• The somatic mutation theory of cancer proposes that cancer begins with a somatic mutation occurring at random in a single cell that then passes the mutation to its progeny, generating a clone of premalignant cells. This clone leads to a full malignant tumor through additional mutations and selection
• PMID 24880866

• Boveri at 100: Boveri, chromosomes and cancer.

• Heim S.
• The Journal of pathology.J Pathol.2014 Jul 16. doi: 10.1002/path.4406. [Epub ahead of print]
• Microscopic studies of chromosomes in cells cultured from leukaemias and solid tumours have helped confirm the central tenet of Boveri's somatic mutation theory of cancer, namely that acquired chromosomal aberrations of susceptible target cells may cause their neoplastic transformation. Cancer cytog
• PMID 25043504

• Whole-exome sequencing of endometriosis identifies frequent alterations in genes involved in cell adhesion and chromatin-remodeling complexes.

• Li X1, Zhang Y2, Zhao L3, Wang L4, Wu Z1, Mei Q1, Nie J1, Li X1, Li Y3, Fu X5, Wang X1, Meng Y6, Han W7.
• Human molecular genetics.Hum Mol Genet.2014 Jun 26. pii: ddu330. [Epub ahead of print]
• Endometriosis is a complex and enigmatic disease that arises from the interplay among multiple genetic and environmental factors. The defining feature of endometriosis is the deposition and growth of endometrial tissues at sites outside of the uterine cavity. Studies to date have established that en
• PMID 24969084

Japanese Journal

• Unusual Clinical and Pathological Presentation of a Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1

• Sakurai Akihiro,Murakami Akiko,Sano Kenji,Uchino Shinya,Fukushima Yoshimitsu
• Endocrine journal 56(7), 887-895, 2009-10-20
• … Genetic analysis of the MEN1 gene in tumor cells revealed a somatic mutation in exon 9 as well as a germline mutation in exon 10. …
• NAID 10026915335

• Somatic NF1 mutation spectra in a family with neurofibromatosis type 1 : toward a theory of genetic modifiers

• WIEST V
• Hum Mutat 22, 423-427, 2003
• NAID 30004131272

• 悪性グリオーマに対する維持化学療法 : 現状と理論的背景(<特集>悪性神経膠腫の最良の治療はなにか)

• 有田 憲生,大西 丘倫,平賀 章壽,早川 徹,生塩 之敬
• 脳神経外科ジャーナル 1(2), 123-128, 1992-04-20
• Osaka Brain Tumor Study Group (OBTSG)で行った,悪性グリオーマに対する化学療法協同研究結果を解析した.導入療法後のnitrosourea系剤継続投与期間の効果に関する検討では,18ヵ月以上継続投与群の術後2年以後の生存期間は18ヵ月未満投与群より有意に延長していた.この維持療法の効果は,主にanaplastic astrocytoma例の生存期間延長によると考え …
• NAID 110003812214

Related Links

• Somatic mutation theory of cancer | definition of somatic ...

so·mat·ic mu·ta·tion the·o·ry of can·cer that cancer is caused by a mutation or mutations in the body cells (as opposed to germ cells), especially nonlethal mutations associated with increased proliferation of the mutant cells. somatic ...

• Somatic mutation theory of cancer | Define Somatic mutation ...

somatic mutation theory of cancer n. The theory that cancer is caused by a mutation or mutations in the body cells, rather than germ cells, especially by nonlethal mutations associated with increased proliferation of the mutant cells.

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★リンクテーブル★

リンク元	「体細胞変異説」
関連記事	「somatic」「somatic mutation」

「体細胞変異説」

　　[★]

英

somatic mutation theory

「somatic」

　　[★]

• adj.

• 体細胞の、体性の、細胞体の、体部の、体細胞性の

関

cell body、soma、somata、somatic cell、somatically

　

「somatic mutation」

　　[★]

• 体細胞突然変異、体細胞変異

関

somatic cell mutation、somatic hypermutation