WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
a salt of salicylic acid (included in several commonly used drugs)

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/03 17:45:35」(JST)

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Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.^[1]

Properties

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.^{[citation needed]}

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells ^[2]^[3]^[4] and also necrosis.^[5] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ulraviolet radiation and electrons.^[6]

References

^ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
^ Klampfer, Lidija; Jörg Cammenga, Hans-Georg Wisniewski, Stephen D. Nimer (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood 93 (7): 2386–94. PMID 10090950. http://bloodjournal.hematologylibrary.org/cgi/content/full/93/7/2386. Retrieved 2011-02-21.
^ Rae, Colin; Susana Langa, Steven J. Tucker, David J. MacEwan (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA 104 (31): 12790–5. doi:10.1073/pnas.0701437104. PMC 1937545. PMID 17646662. http://www.pnas.org/content/104/31/12790. Retrieved 2011-02-21.
^ Stark, Lesley A.; et al (2007-05). "Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis 28 (5): 968–76. doi:10.1093/carcin/bgl220. PMID 17132819. http://carcin.oxfordjournals.org/content/28/5/968. Retrieved 2011-02-21.
^ Schwenger, Paul; Edward Y. Skolnik, Jan Vilcek (1996-04-05). "Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry 271 (14): 8089–94. doi:10.1074/jbc.271.14.8089. PMID 8626494. http://www.jbc.org/content/271/14/8089. Retrieved 2011-02-21.
^ Samson, James. "Vacuum Ultraviolet Spectroscopy". Pied Publications. http://www.mcphersoninc.com/detectors/Sodium%20Salicylate.pdf. Retrieved July 26, 2012.

External links

Chemicalland21
Some synonyms
Safety data for sodium salicylate at Oxford University
Sodium salicylate, definitions at National Cancer Institute

UpToDate Contents

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1. 小児および思春期におけるサリチル酸中毒 salicylate poisoning in children and adolescents
2. 成人におけるサリチル酸（アスピリン）中毒 salicylate aspirin poisoning in adults
3. アスピリン：リウマチ性疾患における作用機序、主な毒性、および使用 aspirin mechanism of action major toxicities and use in rheumatic diseases
4. 非ステロイド性抗炎症剤（NSAIDs）：作用機序 nsaids mechanism of action
5. パラコート中毒 paraquat poisoning

English Journal

Universal dispersing agent for electrophoretic deposition of inorganic materials with improved adsorption, triggered by chelating monomers.

Liu Y1, Luo D1, Ata MS1, Zhang T1, Wallar CJ1, Zhitomirsky I2.
Journal of colloid and interface science.J Colloid Interface Sci.2016 Jan 15;462:1-8. doi: 10.1016/j.jcis.2015.09.053. Epub 2015 Sep 25.
Poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) is a polymeric functional material with a number of unique physical properties, which attracted significant interest of different scientific communities. Films of PAZO were deposited by anodic electrophor
PMID 26433084

Sodium salicylate potentiates the GABAB-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body.

Wang XX1, Jin Y2, Luo B3, Sun JW3, Zhang J4, Wang M5, Chen L6.
Hearing research.Hear Res.2015 Dec 11. pii: S0378-5955(15)00235-X. doi: 10.1016/j.heares.2015.11.013. [Epub ahead of print]
Rebound depolarization (RD) is a voltage response to the offset from pre-hyperpolarization of neuronal membrane potential, which manifests a particular form of the postsynaptic membrane potential response to inhibitory presynaptic inputs. We previously demonstrated that sodium salicylate (NaSal), a
PMID 26688177

pH-Induced Re-entrant Microstructural Transitions in Cationic Surfactant - Hydrotrope Mixtures.

Umeasiegbu CD, Balakotaiah V, Krishnamoorti R.
Langmuir : the ACS journal of surfaces and colloids.Langmuir.2015 Dec 11. [Epub ahead of print]
The structural transitions occurring with change in pH for aqueous mixtures of a cationic surfactant (cetyltrimethylammonium bromide, CTAB) and a hydrotrope (sodium salicylate, NaSal) were investigated at various temperatures using dynamic light scattering and small-angle neutron scattering. Direct
PMID 26654713

Japanese Journal

ひも状ミセル水溶液中を伝播するせん断波の可視化による粘弾性計測

日本機械学会論文集 81(823), 14-00610-14-00610, 2015
NAID 130005130810

大振幅せん断振動によるひも状ミセル水溶液の非線形レオロジー解析

日本機械学会論文集 81(823), 14-00615-14-00615, 2015
NAID 130005130800

界面活性剤溶液への対イオン添加によるゲル化を伴う円管内貫入流れ

日本機械学会論文集 81(823), 14-00172-14-00172, 2015
NAID 130005130784

「サリチル酸ナトリウム」

Sodium salicylate
	IUPAC name Sodium salicylate
	Other names Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Sodium 2-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin, [http://ChEMBL = 447868
Identifiers
CAS number	54-21-7
PubChem	16760658
ChemSpider	5689
UNII	WIQ1H85SYP
EC number	200-198-0
DrugBank	DB01398
KEGG	D00566
ChEMBL	CHEMBL447868
RTECS number	VO5075000
ATC code	N02BA04
Jmol-3D images	Image 1
	SMILES [Na+].O=C([O-])c1ccccc1O ;
	InChI InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 ; Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M InChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1; Key: ABBQHOQBGMUPJH-REWHXWOFAO ;
Properties
Molecular formula	C7H5NaO3
Molar mass	160.11 g/mol
Appearance	White crystals
Melting point	200 °C
Solubility in water	~ 660 g/l at 20 °C
Hazards
R-phrases	R22, R36/37/38
S-phrases	S24/25, S26, S36/37/39
Main hazards	Harmful
NFPA 704	1 1 0
Autoignition; temperature	> 250 °C
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references