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1. ペニシリンの皮膚試験penicillin skin testing [show details]
… a multivalent skin test reagent known as PPL. PPL is important for reliable skin testing, as up to 75 percent of penicillin skin test-positive patients react only to PPL,… The following factors should be considered when planning penicillin skin testing: Skin testing should not be performed in…
2. 即時型ペニシリンアレルギーの評価：皮膚反応試験に基づいた診断方法とその他のβ-ラクタム系抗菌薬との交差反応性試験allergy evaluation for immediate penicillin allergy skin test based diagnostic strategies and cross reactivity with other beta lactam antibiotics [show details]
… cephalosporins: If penicillin skin testing is available and is negative, patients may safely receive carbapenems. If penicillin skin testing is positive, the patient chance of reacting to the carbapenem… reaction and other factors. Demonstrating that the patient has a negative skin test to the desired cephalosporin further increases safety. If skin testing is not available,…
3. 皮膚の異型リンパ球浸潤と診断された患者に対するアプローチapproach to the patient with a diagnosis of atypical lymphocytic infiltrate of the skin [show details]
… atypical lymphocytic infiltrates of the skin. A "watch and wait" approach with symptomatic treatment of the skin lesions is appropriate for most patients.… including BCL-6, CD10, human germinal center associated lymphoma (HGAL), and LIM-only transcription factor 2, are normally expressed by germinal center B lymphocytes. However, the presence of B cells expressing … such as when the lymphocytic infiltrate is sparse or reacting to a limited number of antigens (eg,…
4. 第XI（11）因子欠乏症factor xi eleven deficiency [show details]
… circulates in the inactive form (as a zymogen) and becomes activated to factor XIa, a serine protease. Unlike other coagulation factors, the factor XI zymogen circulates as a homodimer (with subunits stabilized …
5. Skin autograftingskin autografting [show details]
…local and systemic factors that decrease the survival of skin grafts are similar for split-thickness and full-thickness grafts. The main factor that reduces graft take and survival for skin grafts is a lack …

English Journal

Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies.

Elhaji Y, Sasseville D, Pratt M, Asai Y, Matheson K, McLean WHI, Hull PR.
Contact dermatitis. 2019 Jun;80(6)354-358.
Polysensitivity is defined as three or more positive patch test reactions. The role of filaggrin gene (FLG) loss-of-function mutations in patients with polysensitivity has not been studied when barrier bypass and possible preceding barrier damage have been excluded. To determine whether FLG loss of
PMID 30868611

Gender, prick test size and rAra h 2 sIgE level may predict the eliciting dose in patients with peanut allergy: Evidence from the Mirabel survey.

Elegbede CF, Papadopoulos A, Just J, Moneret-Vautrin DA, Deschildre A, Crépet A.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2019 May;49(5)677-689.
Peanut allergy management is based on active avoidance and access to emergency treatment including self-injectable adrenaline. Knowing the dose at which a patient is likely to react is crucial for risk assessment and could significantly improve management by integrating a personalized approach. To d
PMID 30689235

Contact sensitization to hair colours in acquired dermal macular hyperpigmentation: results from a patch and photo-patch test study of 108 patients.

Bishnoi A, Vinay K, Arshdeep , Parsad D, Handa S, Saikia UN, Sendhil Kumaran M.
Journal of the European Academy of Dermatology and Venereology : JEADV. 2019 Mar;().
Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis. To establish contact sensitization to hair colours as an aetiological factor for ADMH. Detailed clinical examination, sk
PMID 30883932

Japanese Journal

ケミカルメディエーターから見た炎症反応の解析と薬物制御機構

大内和雄
藥學雜誌 108(4), 251-270, 1988
… The anaphylactic increase in vascular permeability was found to be substantially mediated by histamine and serotonin although the contents of slow reacting substance (SRS), lyso-form of platelet activating factor (PAF) were high in the pouch fluid in this phase. …
NAID 110003648637

SUPPRESSION OF DELAYED HYPERSENSITIVITY BY MEASLES VIRUS INFECTION IN GUINEA PIGS

山内一也 [他],大田博昭,片岡哲朗,小船富美夫,吉川泰弘,徳永徹
Ｊａｐａｎｅｓｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｂｉｏｌｏｇｙ 34(2), 81-94, 1981
… In the virus-infected animals, the suppressed response to the skin reacting factor was observed as well, however in vitro responsiveness of lymphocytes to PPD was not suppressed. … On the other hand, transient enhancement of skin reactivity to phytohemagglutinin by virus infection was noticed. …
NAID 130003778347