セリンtRNAリガーゼ
- 関
- seryl-tRNA synthetase
WordNet
- a sweetish crystalline amino acid involved in the synthesis by the body of cysteine
- any of various brown and yellow finches of parts of Europe
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/04 08:19:45」(JST)
[Wiki en表示]
| serine-tRNA ligase |
| Identifiers |
| EC number |
6.1.1.11 |
| CAS number |
9023-48-7 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, a serine-tRNA ligase (EC 6.1.1.11) is an enzyme that catalyzes the chemical reaction
- ATP + L-serine + tRNASer AMP + diphosphate + L-seryl-tRNASer
The 3 substrates of this enzyme are ATP, L-serine, and tRNA(Ser), whereas its 3 products are AMP, diphosphate, and L-seryl-tRNA(Ser).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-serine:tRNASer ligase (AMP-forming). Other names in common use include seryl-tRNA synthetase, SerRS, seryl-transfer ribonucleate synthetase, seryl-transfer RNA synthetase, seryl-transfer ribonucleic acid synthetase, and serine translase. This enzyme participates in glycine, serine and threonine metabolism and aminoacyl-trna biosynthesis.
Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1SER, 1SES, 1SET, 1SRY, 1WLE, 2CIM, 2CJ9, 2CJA, 2CJB, 2DQ0, 2DQ1, 2DQ2, and 2DQ3.
References
- Katze JR, Konigsberg W (1970). "Purification and properties of seryl transfer ribonucleic acid synthetase from Escherichia coli". J. Biol. Chem. 245 (5): 923–30. PMID 4906848.
- Makman MH and Cantoni GL (1965). "Isolation of seryl and phenylalanyl ribonucleic acid synthetases from baker's yeast". Biochemistry 4: 1434–1442. doi:10.1021/bi00883a031.
- Webster LT and Davie EW (1961). "Purification and properties of serine-activating enzyme from beef pancreas". J. Biol. Chem. 236: 479–484. PMID 13783661.
- Ohama T, Yang DC, Hatfield DL (1994). "Selenocysteine tRNA and serine tRNA are aminoacylated by the same synthetase, but may manifest different identities with respect to the long extra arm". Arch. Biochem. Biophys. 315 (2): 293–301. doi:10.1006/abbi.1994.1503. PMID 7986071.
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Enzymes: CO CS and CN ligases (EC 6.1-6.3)
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| 6.1: Carbon-Oxygen |
- Aminoacyl tRNA synthetase
- Tyrosine
- Tryptophan
- Threonine
- Leucine
- Isoleucine
- Lysine
- Alanine
- Valine
- Methionine
- Serine
- Aspartate
- D-alanine-poly(phosphoribitol) ligase
- Glycine
- Proline
- Cysteine
- Glutamate
- Glutamine
- Arginine
- Phenylalanine
- Histidine
- Asparagine
- Aspartate
- Glutamate
- Lysine
|
|
| 6.2: Carbon-Sulfur |
- Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase
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| 6.3: Carbon-Nitrogen |
- Glutamine synthetase
- Ubiquitin ligase
- Cullin
- Von Hippel-Lindau tumor suppressor
- UBE3A
- Mdm2
- Anaphase-promoting complex
- UBR1
- Glutathione synthetase
- CTP synthase
- Adenylosuccinate synthase
- Argininosuccinate synthetase
- Holocarboxylase synthetase
- GMP synthase
- Asparagine synthetase
- Carbamoyl phosphate synthetase
- Gamma-glutamylcysteine synthetase
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Ligases: carbon-carbon ligases (EC 6.4)
|
|
| Biotin dependent carboxylase |
- Pyruvate carboxylase
- Acetyl-CoA carboxylase
- Propionyl-CoA carboxylase
- Methylcrotonyl-CoA carboxylase
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| Other |
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Enzymes: Phosphoric ester and nitrogen-metal ligases (EC 6.5-6.6)
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| 6.5: Phosphoric Ester |
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| 6.6: Nitrogen-Metal |
- Magnesium chelatase
- Cobaltochelatase
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol.
- Lin J1, Zhong JJ2.
- Bioprocess and biosystems engineering.Bioprocess Biosyst Eng.2017 Apr 5. doi: 10.1007/s00449-017-1763-5. [Epub ahead of print]
- PMID 28382459
- MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.
- Anderton B1,2, Camarda R1,2, Balakrishnan S1,2, Balakrishnan A1,2,3, Kohnz RA4, Lim L1,2, Evason KJ5, Momcilovic O1,2, Kruttwig K1,2, Huang Q6, Xu G6, Nomura DK4, Goga A7,2.
- EMBO reports.EMBO Rep.2017 Apr;18(4):569-585. doi: 10.15252/embr.201643068. Epub 2017 Feb 20.
- PMID 28219903
- A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects.
- Wang Y1, Zhou XL2, Ruan ZR3, Liu RJ3, Eriani G4, Wang ED5.
- The Journal of biological chemistry.J Biol Chem.2016 Mar 18;291(12):6507-20. doi: 10.1074/jbc.M115.700849. Epub 2016 Jan 25.
- PMID 26811336
★リンクテーブル★
[★]
セリルtRNA合成酵素、セリルtRNAシンテターゼ
- 関
- serine-tRNA ligase
[★]
- 英
- serine-tRNA ligase
- 関
- セリルtRNA合成酵素
[★]
トランスファーRNA, transfer RNA, 転位RNA
[★]
リガーゼ、連結酵素
- 関
- synthetase
[★]
セリン
- 関
- L-serine、S、Ser
[★]
トランスファーRNA transfer RNAs
[★]
tRNAリガーゼ
- 関
- RNA ligase