関: S、serine

同: セリン

WordNet

a sweetish crystalline amino acid involved in the synthesis by the body of cysteine
the United States federal department that administers all federal programs dealing with health and welfare; created in 1979 (同)Health and Human Services, HHS
the 19th letter of the Roman alphabet (同)s

PrepTutorEJDIC

sulfurの化学記号 / {略}South[ern]
seleniumの化学記号
serial / series / sermon

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/26 17:37:50」(JST)

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Ser or SER may refer to:

Surin Elephant Round-up (SER), usually takes place on the third weekend of November in Surin province, Isan, Thailand

Entertainment

Cadena SER, a Spanish radio channel
Darren Cullen (graffiti artist SER), a British graffiti artist
Another spelling of 'Sir' in some fantasy and science fiction works

Geography

Ser, a village in Bogdand Commune, Satu Mare County, Romania
Samuel-Brisson Ecological Reserve (SER), an ecological reserve in Quebec, Canada established in 1988
Serpentine-de-Coleraine Ecological Reserve (SER), an ecological reserve in Quebec, Canada established in 2003
Serres, Greece, a municipality
Shin-Keisei Electric Railway (SER), a private railway in Chiba, Japan connecting Narashino and Matsudo
South Eastern Railway (Quebec)
South Eastern Railway (UK)
Southeastern Railway (Russia)
SER, National Rail code for St Erth railway station in Cornwall, England

Physical sciences

ser, the standard abbreviation for serine in biochemistry
Ser, the standard astronomical abbreviation for the constellation Serpens
Smooth Endoplasmic Reticulum (SER), a cellular compartment

Politics

Social-Economic Council (Sociaal-Economische Raad, SER), of the Netherlands
Supreme Exalted Ruler (SER), president of Sigma Alpha Rho fraternity

Print media

SER (magazine), a Nicaraguan magazine of fashion and lifestyle published by MADERA & Co.

Technology

Ser (unit), an obsolete unit of capacity in India
Search engine ranking (SER), an Internet search engine metric
Sequence of events recorder (SER), electronic device which monitors external inputs and records changes
Single Ended Recuperative (SER) burner, a type of furnace
SIP Express Router (SER), a configurable proxy or redirect server for Session Initiation Protocol (SIP)
Soft Error Rate (SER), an error metric in electronics and computing systems
Systems Engineering Report (SER).

This disambiguation page lists articles associated with the title Ser.
If an internal link led you here, you may wish to change the link to point directly to the intended article.

UpToDate Contents

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1. 腎性尿崩症の臨床症状および原因 clinical manifestations and causes of nephrogenic diabetes insipidus
2. 赤血球産生調節 regulation of erythropoiesis

English Journal

Use of β-cyclodextrin and activated carbon for quantification of Salmonella enterica ser. Enteritidis from ground beef by conventional PCR without enrichment.

Opet NJ, Levin RE.Author information Department of Food Science, Massachusetts Agricultural Experiment Station, University of Massachusetts, Amherst, MA 01003, USA.AbstractThe high level of PCR inhibitors present in ground beef is a major factor that affects molecular based techniques, such as the polymerase chain reaction (PCR), for the detection of Salmonella enterica. In this study, the use of β-cyclodextrin and milk protein coated activated carbon (MP-CAC) allowed the PCR to detect low numbers of Salmonella seeded into ground beef without enrichment of samples. invA was used as target gene in the conventional PCR protocol. With 25 g samples of ground beef containing 7.0, 15, and 27% fat, treatment of stomached samples with 5.0, 10, and 15% β-cyclodextrin respectively followed by treatment with MP-CAC, resulted in the detection of 3 CFU/g (equivalent to 75 CFU in a 25 g sample). The total assay time was 4.5 h. The methodology described in this study for the detection of S. enterica in ground beef without enrichment is rapid, sensitive, and has the potential to be applied to a number of complex food matrices to detect low numbers of food-borne bacterial pathogens.
Food microbiology.Food Microbiol.2014 Apr;38:75-9. doi: 10.1016/j.fm.2013.08.014. Epub 2013 Aug 31.
The high level of PCR inhibitors present in ground beef is a major factor that affects molecular based techniques, such as the polymerase chain reaction (PCR), for the detection of Salmonella enterica. In this study, the use of β-cyclodextrin and milk protein coated activated carbon (MP-CAC) allowe
PMID 24290629

Isolation and molecular characterization of Salmonella enterica serovar Enteritidis from poultry house and clinical samples during 2010.

Mezal EH, Sabol A, Khan MA, Ali N, Stefanova R, Khan AA.Author information Microbiology Division, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; University of Arkansas at Little Rock, Little Rock, AR 72205, USA; University of Thi-Qar, Science of College, Biology of Dept., Thi-Qar, Iraq.AbstractA total of 60 Salmonella enterica serovar (ser.) Enteritidis isolates, 28 from poultry houses and 32 from clinical samples, were isolated during 2010. These isolates were subjected to testing and analyzed for antibiotic resistance, virulence genes, plasmids and plasmid replicon types. To assess genetic diversity, pulsed-field gel electrophoresis (PFGE) fingerprinting, using the XbaI restriction enzyme, Multiple-Locus Variable-Number Tandem Repeat Analysis (MLVA) and plasmid profiles were performed. All isolates from poultry, and 10 out of 32 clinical isolates were sensitive to ampicillin, chloramphenicol, gentamicin, kanamycin, nalidixic acid, sulfisoxazole, streptomycin, and tetracycline. Twenty-one of thirty-two clinical isolates were resistant to ampicillin and tetracycline, and one isolate was resistant to nalidixic acid. PFGE typing of sixty ser. Enteritidis isolates by XbaI resulted in 10-12 bands and grouped into six clusters each with similarity from 95% to 81%. The MLVA analysis of sixty isolates gave 18 allele profiles with the majority of isolates displayed in three groups, and two clinical isolates found to be new in the PulseNet national MLVA database. All isolates were positive for 12 or more of the 17 virulence genes mostly found in S. enterica (spvB, spiA, pagC, msgA, invA, sipB, prgH, spaN, orgA, tolC, iroN, sitC, IpfC, sifA, sopB, and pefA) and negative for one gene (cdtB). All isolates carried a typical 58 kb plasmid, type Inc/FIIA. Three poultry isolates and one clinical isolate carried small plasmids with 3.8, 6, 7.6 and 11.5 kb. Ten of the clinical isolates carried plasmids, with sizes 36 and 38 kb, types IncL/M and IncN, and one isolate carried an 81 kb plasmid, type IncI. Southern hybridization of a plasmid with an Inc/FIIA gene probe hybridized one large 58 kb plasmid in all isolates. Several large and small plasmids from poultry isolates were not typed by our PCR-based method. These results confirmed that PFGE fingerprinting has limited discriminatory power for ser. Enteritidis in both poultry and clinical sources. However, the plasmid and MLVA allele profiles were a useful and important epidemiology tool to discriminate outbreak strains of ser. Enteritidis from poultry and clinical samples.
Food microbiology.Food Microbiol.2014 Apr;38:67-74. doi: 10.1016/j.fm.2013.08.003. Epub 2013 Aug 27.
A total of 60 Salmonella enterica serovar (ser.) Enteritidis isolates, 28 from poultry houses and 32 from clinical samples, were isolated during 2010. These isolates were subjected to testing and analyzed for antibiotic resistance, virulence genes, plasmids and plasmid replicon types. To assess gene
PMID 24290628

Phosphorylation of Ser-180 of rat aquaporin-4 shows marginal affect on regulation of water permeability: molecular dynamics study.

Sachdeva R, Singh B.Author information a Bioinformatics Center , CSIR-Institute of Microbial Technology, Council of Scientific and Industrial Research , Sector 39A, Chandigarh , 160036 , India .AbstractWater permeation through rat aquaporin-4 (rAQP4), predominantly found in mammalian brain is regulated by phosphorylation of Ser-180. The present study has been carried out to understand the structural mechanism of regulation of water permeability across the channel. Molecular dynamics (MD) simulations have been carried out to investigate the structural changes caused due to phosphorylation of Ser-180 in the tetrameric assembly of rAQP4 along with predicted C-terminal region (255-323). The interactions involving opposite charges are observed between cytoplasmic loops and the C-terminal region during MD simulations. This results in movement of C-terminal region of rAQP4 towards the cytoplasmic mouth of water channel. Despite this movement, there was a gap between C-terminal region and cytoplasmic mouth of the channel through which water molecules were able to gain entry into the channel. The interactions between C-terminus and loop D of neighboring monomers in a tetrameric assembly appear to prevent the complete closure of cytoplasmic mouth of the water channel. Further, the rates of water permeation through phosphorylated and unphosphorylated rAQP4 have also been compared. The simulation studies showed a continuous movement of water in a single file across pore of unphosphorylated as well as phosphorylated rAQP4.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2014 Apr;32(4):555-66. doi: 10.1080/07391102.2013.780981. Epub 2013 May 7.
Water permeation through rat aquaporin-4 (rAQP4), predominantly found in mammalian brain is regulated by phosphorylation of Ser-180. The present study has been carried out to understand the structural mechanism of regulation of water permeability across the channel. Molecular dynamics (MD) simulatio
PMID 23651078

Japanese Journal

Development of a practical NF1 genetic testing method through the pilot analysis of five Japanese families with neurofibromatosis type 1

Okumura Akiko,Ozaki Mamoru,Niida Yo
Brain and Development 37(7), 677-689, 2015-08-01
… In family 3, c.4402A>G was detected in exon 34 and the p.Ser1468Gly missense mutation was predicted. …
NAID 120005593951

A novel resting form of the trinuclear copper center in the double mutant of a multicopper oxidase, CueO, Cys500Ser/Glu506Ala

Kajikawa Takao,Sugiyama Ryosuke,Kataoka Kunishige,Sakurai Takeshi
Journal of Inorganic Biochemistry 149, 88-90, 2015-08
… A multicopper oxidase, CueO was doubly mutated at its type I copper ligand, Cys500 and an acidic amino acid residue located in the proton transfer pathway, Glu506, to Ser and Ala, respectively. … Cys500Ser/Glu506Ala was mainly in a novel resting form to afford the absorption band at ca. … However, Cys500Ser/Glu506Ala gave the same reaction intermediate (peroxide intermediate) as that from Cys500Ser and Cys500Ser/Glu506Gln. …
NAID 120005613973

Fano manifolds with nef tangent bundle and large Picard number

WATANABE Kiwamu
Proceedings of the Japan Academy. Ser
NAID 40020519528

「アミノ酸」

　　[★]

英: amino acid
関: ケト原性アミノ酸、糖原性アミノ酸

定義

アミノ基とカルボキシ基を両方持つもの・・・？

L-アミノ酸、D-アミノ酸がある。一般的に生合成されるポリペプチドはL-アミノ酸を材料としている。D-アミノ酸は細菌が産生し、ごく短いペプチドとして特に、細胞壁に存在する。これはペプチダーゼによる分解を免れるためと言われている。D-アミノ酸を含むポリペプチドは、通常の翻訳経路で生合成されない。(FB.58)
ケト原性：Leu, Lys
糖原性/ケト原性：Ile, Phe, Trp
糖原性：Met, Thr, Val, Arg, His

ArgとHisは成長期に必要

PriVaTe TIM HALL

一覧

分類

極性

電荷

名前

1

3

糖原性

ケトン原性

必須アミノ酸

分枝アミノ酸

pK1
α-COOH

pK2
α-NH2

pKR
側鎖

側鎖

疎水性アミノ酸

無

グリシン

G

Gly

2.35

9.78

―H

無

アラニン

A

Ala

2.35

9.87

―CH3

無

バリン

V

Val

○

2.29

9.74

―CH(CH3)2

無

フェニルアラニン

F

Phe

○

○3

2.2

9.31

―○C6H5

無

プロリン

P

Pro

1.95

10.64

αCとNH2の間に
―CH2CH2CH2-

無

メチオニン

M

Met

○2

2.13

9.28

―CH2CH2-S-CH3

無

イソロイシン

I

Ile

○

2.32

9.76

―CH(CH3)CH2CH3

無

ロイシン

L

Leu

○

2.33

9.74

―CH2CH(CH3)2

荷電アミノ酸

有

酸性

アスパラギン酸

D

Asp

1.99

9.9

3.9
β-COOH

―CH2COOH

有

酸性

グルタミン酸

E

Glu

2.1

9.47

4.07
γ-COOH

―CH2CH2COOH

有

塩基性

リシン

K

Lys

○

2.16

9.06

10.54
ε-NH2

側鎖のCH2は4つ
―-CH2CH2CH2CH2NH2

有

塩基性

アルギニン

R

Arg

○1

1.82

8.99

12.48
グアニジウム基

側鎖のCH2は3つ
―CH2CH2CH2-NH-C-(NH2)NH

極性アミノ酸

有

無

セリン

S

Ser

2.19

9.21

―CH2OH

有

無

スレオニン

T

Thr

○

2.09

9.1

―CH(CH3)OH

有

無

チロシン

Y

Tyh

○

2.2

9.21

10.46
フェノール

―CH2-φ

有

塩基性

ヒスチジン

H

His

○

1.8

9.33

6.04
イミダゾール基

―CH2-C3H3N2

有

無

システイン

C

Cys

1.92

10.7

8.37
-SH基

―CH2-SH

有

無

アスパラギン

N

Asn

2.14

8.72

―CH2-CO-NH2

有

無

グルタミン

Q

Gln

2.17

9.13

―CH2-CH2-CO-NH2

無

トリプトファン

W

Trp

○

2.46

9.41

―Indol ring

1 人体で合成できるが、不十分。

2 Cysが足らなければ、Metから合成することになる。

	名称	基となるアミノ酸
修飾されたアミノ酸	シスチン	システイン	システイン2分子が酸化されて生成する。
	ヒドロキシプロリン	プロリン	ゼラチン、コラーゲンに含まれる。
	ヒドロキシリジン	リジン	ゼラチン、コラーゲンに含まれる。
	チロキシン	チロシン	甲状腺タンパク質に含まれる。
	O-ホスホセリン		カゼインなど、多くのリンタンパク質に含まれる。
	デスモシン
蛋白質の構成要素ではない	オルニチン	アルギニン	ミトコンドリア中でカルバモイルリン酸と反応
	シトルリン	オルニチン、カルバモイルリン酸
	クレアチン	アルギニン、グリシン
	γアミノ酪酸	アルギニン

必須アミノ酸

準必須	ア	アルギニン
必須	メ	メチオニン
	フ	フェニルアラニン
	リ	リジン
	バ	valine
	ス	スレオニン
	ト	トリプトファン
	ロ	ロイシン
	イ	イソロイシン
準必須	ヒ	ヒスチジン