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Synthesis and dual histamine H₁ and H₂ receptor antagonist activity of cyanoguanidine derivatives.

Sadek B1, Alisch R, Buschauer A, Elz S.
Molecules (Basel, Switzerland).Molecules.2013 Nov 15;18(11):14186-202. doi: 10.3390/molecules181114186.
Premedication with a combination of histamine H₁ receptor (H₁R) and H₂ receptor (H₂R) antagonists has been suggested as a prophylactic principle, for instance, in anaesthesia and surgery. Aiming at pharmacological hybrids combining H₁R and H₂R antagonistic activity, a series of cyanoguan
PMID 24248146

Effects of oral rehydration therapy on gastric volume and pH in patients with preanesthetic H2 antagonist.

Nakai K1, Niwa H, Kitayama M, Satoh Y, Hirota K.
Journal of anesthesia.J Anesth.2012 Dec;26(6):936-8. doi: 10.1007/s00540-012-1449-8. Epub 2012 Jul 20.
Recent preanesthetic fasting practice allows patients to take clear fluids up to 2 h before surgery without taking any antacid for the prophylaxis of aspiration pneumonia; this practice is defined as oral rehydration therapy (ORT). It has been reported that with ORT the gastric volume may be signif
PMID 22814485

Different effects of two types of H2-receptor antagonists, famotidine and roxatidine, on the mucus barrier of rat gastric mucosa.

Shikama N1, Ichikawa T, Iwai T, Yamamoto H, Kida M, Koizumi W, Ishihara K.
Biomedical research (Tokyo, Japan).Biomed Res.2012 Feb;33(1):45-51.
Compared with the aggressive factors, little attention has been paid to the mucosal defensive factors in ulcer therapy, and the role of the H2-receptor antagonists in gastric mucosal protection has not been well characterized. In the present study, the effects of different types of H2-receptor antag
PMID 22361886

Roxatidine-and Cimetidine-Induced Angiogenesis Inhibition Suppresses Growth of Colon Cancer Implants in Syngeneic Mice

Tomita Kazuyoshi,Izumi Kazuki,Okabe Susumu
Journal of pharmacological sciences 93(3), 321-330, 2003-11-01
… The effect of roxatidine acetate hydrochloride (roxatidine), an H2-receptor antagonist, on the growth of colon cancer implanted in mice was examined and compared with that of cimetidine. … Both roxatidine and cimetidine significantly suppressed the growth of Colon 38 tumor implants. …
NAID 130000073923

Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO)in Rat Gastric Parietal Cells

Kimura Norio,Miwa Takashi
Acta histochemica et cytochemica 35(1), 23-31, 2002
… Histamine as an acid secretagogue and H_2-blocker (roxatidine acetate hydrochloride) and a proton pump inhibitor (Omeprazole) as acid secretion inhibitors, in single and repeated doses, were administered to investigate associated lipid peroxidation in rat gastric parietal cells. …
NAID 110003150868