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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/10/29 22:59:29」(JST)
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Risedronic acid
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy
category |
- AU: B3
- US: C (Risk not ruled out)
|
Routes of
administration |
Oral |
ATC code |
|
Legal status |
Legal status |
- UK: POM (Prescription only)
- US: ℞-only
|
Pharmacokinetic data |
Bioavailability |
0.63% |
Protein binding |
~24% |
Metabolism |
None |
Biological half-life |
1.5 h |
Excretion |
Renal and fecal |
Identifiers |
IUPAC name
- (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid
|
CAS Number |
|
PubChem CID |
|
IUPHAR/BPS |
|
DrugBank |
|
ChemSpider |
|
UNII |
|
ChEMBL |
|
ECHA InfoCard |
100.116.436 |
Chemical and physical data |
Formula |
C7H11NO7P2 |
Molar mass |
283.112 g/mol |
3D model (JSmol) |
|
SMILES
-
OC(Cc1cccnc1)(P(=O)(O)O)P(=O)(O)O
|
InChI
-
InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15) N
-
Key:IIDJRNMFWXDHID-UHFFFAOYSA-N N
|
NY (what is this?) (verify) |
Risedronic acid (INN) often used as its sodium salt risedronate sodium (USAN) is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone. It is produced and marketed by Warner Chilcott, Sanofi-Aventis, and in Japan by Takeda under the trade names Actonel, Atelvia, and Benet. It is also available in a preparation that includes a calcium carbonate supplement, as Actonel with Calcium.
Contents
- 1 Controversies
- 2 See also
- 3 References
- 4 External links
Controversies
In January 2006 P&G and its marketing partner Sanofi-Aventis filed a Lanham Act false claims lawsuit against rival drugmakers Roche and GlaxoSmithKline claiming false advertising about Boniva.[1] The manufacturers of Boniva, a rival bisphosphonate, were accused in the suit of causing a "serious public health risk" through misrepresentation of scientific findings. In a ruling on September 7, 2006 U.S. District Judge Paul A. Crotty rejected P&G's attempted injunction. P&G was criticized for attempting to "preserve its market share by denigrating Boniva". Judge Crotty wrote that "Roche was clearly entitled to respond with its own data, provided that the data was truthfully and accurately presented".[2]
In 2006, P&G faced controversy over its handling of clinical research involving risedronate (News Reports[3] and discussion).[4]
In common with other bisphosphonate drugs, risedronate appears to be associated with the rare side effect osteonecrosis of the jaw, often preceded by dental procedures inducing trauma to the bone.
See also
References
- ^ "P&G Press statement". Uk.pg.com. Retrieved 2013-03-01.
- ^ NY fed judge finds promotions for bone drug Boniva are fair Associated Press, 7 Sept 2006[dead link]
- ^ http://www.thejabberwock.org/wiki/index.php?title=Actonel_Case_Media_Reports
- ^ "Scientific Misconduct Blog". Scientific-misconduct.blogspot.com. Retrieved 2013-03-01.
External links
- Actonel adverse events reported to the FDA
- Risedronic acid bound to proteins in the PDB
Drugs for treatment of bone diseases (M05)
|
Bisphosphonates |
- Nitrogenous (Alendronic acid
- ibandronic acid
- incadronic acid
- pamidronic acid
- risedronic acid
- zoledronic acid)
Non-nitrogenous (Etidronic acid
- clodronic acid
- tiludronic acid)
|
Bone morphogenetic proteins |
- Dibotermin alfa
- Eptotermin alfa
|
Other |
- Resorption inhibitor (Ipriflavone)
- Aluminium chlorohydrate
- Dual action bone agent (Strontium ranelate)
RANKL inhibitor (Denosumab)
- Cathepsin K inhibitor (Odanacatib)
- Calcium
- Vitamin D
|
UpToDate Contents
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English Journal
- Risedronate as an intra-abdominal sepsis mimic: a case report.
- Shah S1, Jeremiah C, Johnson D, Baker S.
- Archives of osteoporosis.Arch Osteoporos.2015 Dec;10(1):213. doi: 10.1007/s11657-015-0213-8. Epub 2015 Mar 20.
- This case report highlights the potential severity of bisphosphonate-associated reactions.CASE REPORT: A 76-year-old lady underwent several hospital admissions for investigation of fever associated with rigors, abdominal pain, and vomiting.DISCUSSION: Despite multiple investigations, no cause was fo
- PMID 25792348
- Effects of swimming associated with risedronate in osteopenic bones: An experimental study with ovariectomized rats.
- Paliologo T1, Shimano RC2, Shimano AC3, Macedo AP4, Falcai MJ5, Issa JP6.
- Micron (Oxford, England : 1993).Micron.2015 Nov;78:40-4. doi: 10.1016/j.micron.2015.07.002. Epub 2015 Jul 10.
- Physical activity and risedronate sodium have effects on metabolic bone diseases, maintaining the integrity of bone tissue. Our objective was to evaluate the effects of swimming associated with risedronate as a prophylactic means in osteopenic bone of ovariectomized rats. A total of 24 animals of th
- PMID 26210684
- On-cartridge derivatization coupled with solid-phase extraction for the ultra-sensitive determination of minodronic acid in human plasma by LC-MS/MS method.
- Yang Y1, Liu C1, Zhang Y1, Zhou L1, Zhong D1, Chen X2.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Oct 10;114:408-15. doi: 10.1016/j.jpba.2015.05.038. Epub 2015 Jun 18.
- Minodronic acid (MA) is a third-generation bisphosphonate (BP). Its high potency allows lower doses to be administered in clinical settings compared with other BPs, which results in extremely low systemic exposure. Therefore, it is essential to develop an ultra-sensitive bioassay for pharmacokinetic
- PMID 26117452
Japanese Journal
- Industrial Info. リセドロネート(アクトネル)の骨折予防効果 : 大腿骨近位部骨折予防効果を中心に
- リセドロネート低反応性の多骨型 Paget 病の1例
- 正本 和誉,大浦 好一郎,坂口 雅彦,富原 光雄
- 中部日本整形外科災害外科学会雑誌. 中部日本整形外科災害外科学会抄録 55(3), 533-534, 2012-05-01
- NAID 10030775672
Related Links
- You should eat plenty of foods that are rich in calcium and vitamin D while you are taking risedronate. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If ...
- Learn about the prescription medication Actonel (Risedronate Sodium), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. ... What are the possible side effects of risedronate (Actonel, Atelvia)? ...
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★リンクテーブル★
[★]
- 英
- bisphosphonate
- 同
- ビスフォスフォネート、ビスホスホネート、ビスホスホン酸、ビスホスホネート製剤
- 関
- 骨粗鬆症
[★]
- 英
- risedronate risedronic acid
- 般
- リセドロン酸ナトリウム水和物 sodium risedronate hydrate
- 商
- アクトネル、ベネット
- 同
- リセドロネート
- 関
- 骨粗鬆症
添付文書
- http://www.info.pmda.go.jp/go/pack/3999019F2030_1_06/3999019F2030_1_06?view=body
-ベネット
[★]
- 関
- risedronate、sodium risedronate hydrate
[★]
- 関
- risedronate、risedronic acid