- 関
- respiratory system agent
WordNet
- that stimulates; "stimulant phenomena" (同)stimulating
- a drug that temporarily quickens some vital process (同)stimulant_drug, excitant
- pertaining to respiration; "respiratory assistance"
- a breathing device for administering long-term artificial respiration (同)inhalator
PrepTutorEJDIC
- 刺激[するもの] / 興奮性飲食物
- 呼吸の,呼吸作用の,呼吸のための
- 《米》人工呼吸装置 / (一般に)マスク;防毒マスク
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/14 15:05:15」(JST)
[Wiki en表示]
Doxapram
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Systematic (IUPAC) name |
1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one
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Clinical data |
Legal status |
|
Routes of
administration |
Intravenous |
Identifiers |
CAS Registry Number |
309-29-5 Y |
ATC code |
R07AB01 |
PubChem |
CID: 3156 |
DrugBank |
DB00561 Y |
ChemSpider |
3044 Y |
UNII |
94F3830Q73 Y |
KEGG |
D07873 Y |
ChEBI |
CHEBI:681848 Y |
ChEMBL |
CHEMBL1754 Y |
Chemical data |
Formula |
C24H30N2O2 |
Molecular mass |
378.507 g/mol |
SMILES
-
O=C4N(CC)CC(CCN1CCOCC1)C4(c2ccccc2)c3ccccc3
|
InChI
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InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3 Y
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Key:XFDJYSQDBULQSI-UHFFFAOYSA-N Y
|
Y (what is this?) (verify) |
Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
Contents
- 1 Mechanism of action
- 2 Appearance
- 3 Uses
- 4 Side effects
- 5 See also
- 6 References
Mechanism of action
Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem.
Appearance
Doxapram is a white to off-white, odorless, crystalline powder that is stable in light and air. It is soluble in water, sparingly soluble in alcohol and practically insoluble in ether. Injectable products have a pH from 3.5-5. Benzyl alcohol or chlorobutanol is added as a preservative agent in the commercially available injections.
Uses
Doxapram is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure. It may be useful for treating respiratory depression in patients who have taken excessive doses of drugs such as buprenorphine which may fail to respond adequately to treatment with naloxone.[1]
It is equally effective as pethidine in suppressing shivering after surgery.[2]
Side effects
Side effects include high blood pressure, panic attacks, rapid heart rate, tremor, sweating and vomiting. Convulsions have been reported. Its use is relatively contraindicated in people with coronary heart disease, epilepsy, and high blood pressure. It is also contraindicated in newborns and small children, mainly due to the presence of benzyl alcohol, which is included as a preservative.
See also
- Pentethylcyclanone (similar structure)
References
- ^ Buprenorphine Drug Data Sheet
- ^ Singh, P; Dimitriou, V; Mahajan, RP; Crossley, AW (1993). "Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering". British journal of anaesthesia 71 (5): 685–8. doi:10.1093/bja/71.5.685. PMID 8251281.
Other respiratory system products (R07)
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|
Lung surfactants |
|
|
Respiratory stimulants |
- Almitrine
- Amiphenazole
- Bemegride
- Dimefline
- Doxapram
- Etamivan
- GAL-021
- Mepixanox
- Nikethamide
- Pentetrazol
- Prethcamide
|
|
5-HT4 receptor agonists |
|
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Other agents for treating respiratory depression |
- Ivacaftor
- Nitric oxide
- BW373U86
- CX-546
- CX-717
|
|
Index of the respiratory system
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|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Chest trauma
- Infection
- common cold
- pneumonia
- tuberculosis
- Other
- Symptoms and signs
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|
Treatment |
- Procedures
- Drugs
- nasal
- throat
- obstructive airway diseases
- cough and cold
- histaminergics
- pulmonary arterial hypertension
- other
- Surgery
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Efficacy of leukotriene receptor antagonist with anti-H1 receptor antagonist plus anti-H2 receptor antagonist for treatment of refractory chronic idiopathic urticaria.
- Wan KS1, Chang YS.
- The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):459-61. doi: 10.3109/09546634.2013.849791. Epub 2013 Nov 5.
- BACKGROUND: The efficacy of the combination of leukotriene receptor antagonist (LRA) and H1 antihistamine was similar to the synergistic regimen of H1 and H2 antihistamine for treatment of chronic idiopathic urticaria (CIU). However, the effective rates of these two regimens were only 53.3% and 63.3
- PMID 24192062
- Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity?
- Neves KB, Lobato NS1, Lopes RA2, Filgueira FP2, Zanotto CZ1, Oliveira AM3, Tostes RC2.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jul;127(2):111-22. doi: 10.1042/CS20130286.
- The adipokine chemerin has been implicated in cardiovascular complications associated with obesity and the metabolic syndrome. Chemerin has direct effects on the vasculature, augmenting vascular responses to contractile stimuli. As NO/cGMP signalling plays a role in vascular dysfunction associated w
- PMID 24498891
- Evaluation of dedicated infectious diseases pharmacists on antimicrobial stewardship teams.
- Yu K1, Rho J2, Morcos M2, Nomura J2, Kaplan D2, Sakamoto K2, Bui D2, Yoo S2, Jones J2.
- American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.Am J Health Syst Pharm.2014 Jun 15;71(12):1019-28. doi: 10.2146/ajhp130612.
- PURPOSE: Patient care improvements and cost savings achieved by a large integrated health system through the implementation of antimicrobial stewardship programs (ASPs) at two hospitals are reported.METHODS: A pre-post analysis was conducted to evaluate cost and quality outcomes at the two ASP sites
- PMID 24865759
Japanese Journal
- Utility of MostGraph and Fractional Exhaled Nitric Oxide Measurement in Chronic Cough
- 中野 千裕
- 東邦医学会雑誌 61(2), 81-91, 2014-03
- … Respiratory resistance was measured with the MostGraph-01 device (Chest MI Inc., Tokyo, Japan), FENO was measured with the NIOX-MINO (R) portable analyzer (Aerocrine, AB, Solna, Sweden), and pulmonary function was evaluated with spirometry. … Participants were treated with a combination of β stimulant and inhaled corticosteroid. …
- NAID 120005419019
- アスリートと咳(慢性咳嗽を中心に)―最近の研究の動向―
- 田中 繁宏
- 健康運動科学 1, 1-5, 2010-12
- … Cough is aprotective reflex of the respiratory tract that is mainly used to clear the upper airways. … Chroniccough lasting for more than 8 weeks is commonly seen by the out patient respiratory or laryngealphysicians. … Inhaled ciclesonide( corticosteroid) combined with tulobuterol(β2-stimulant) is recommended for the treatment of CVA because these agents are likelyto act on peripheral airways. …
- NAID 120005265256
- β_2刺激薬吸入により喫煙誘発胸痛発作が消失した1例
- 谷口 浩和,神原 健太,今西 信悟,阿保 斉,泉 三郎
- 日本呼吸器学会雑誌 = The journal of the Japanese Respiratory
- NAID 10024821563
Related Links
- Respiratory stimulant. From Wikipedia, the free encyclopedia. Jump to: navigation, search. A respiratory stimulant is a drug which acts to increase the action of the respiratory system. An example is doxapram.
Related Pictures
★リンクテーブル★
[★]
- 英
- respiratory stimulant, respiratory stimulants
- 関
- 延髄に直接作用して呼吸興奮と血圧上昇作用を示す。臨床応用は限られる (SPC.272)
- 過量:唾液分泌過多、悪心、嘔吐、不整脈、けいれん (SPC.272)
- 頚動脈体や大動脈体および延髄の化学受容器を刺激して呼吸興奮を起こす。即効性で持続時間は短い (SPC.272)
- 気道粘膜、食道および胃粘膜を刺激して反射的に呼吸興奮を起こす (SPC.272)
- 英
- respiratory stimulants
[★]
- 英
- respiratory stimulant
- 関
- かつて、中枢抑制薬や麻薬による呼吸抑制に用いられていた
- 保存的療法より死亡率が高く使われなくなった (SPC.210)
[★]
- 関
- respiratory stimulant
[★]
- 英
- respiratory stimulant
- 関
- 呼吸器作用薬
[★]
- 関
- breath、breathe、breathing、respiration、respiratory mechanics、respiratory organ、respiratory tract
[★]
- 関
- activator、agonist、agonistic、enhancer、irritant、irritant chemical、irritants、stimulating agent