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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/09 07:03:41」(JST)

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English Journal

  • Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors.
  • Huang C, Li WG, Zhang XB, Wang L, Xu TL, Wu D, Li Y.SourceInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; Neuroscience Division, Department of Biochemistry and Molecular Cell Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
  • Neuropharmacology.Neuropharmacology.2013 Feb;65:1-11. doi: 10.1016/j.neuropharm.2012.09.001. Epub 2012 Sep 10.
  • Alpha (α)-asarone is a major effective compound isolated from the Chinese medicinal herb Acorus gramineus, which is widely used in clinical practice as an antiepileptic drug; however, its mechanism of action remains unclear. In this study, we have characterized the action of α-asarone on the excit
  • PMID 22975146
  • The mu-opioid receptor-selective peptide antagonists, antanal-1 and antanal-2, produce anticonvulsant effects in mice.
  • Fichna J, Socała K, Nieoczym D, Gach K, Perlikowska R, Janecka A, Wlaź P.SourceDepartment of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2013 Jan 10;40:126-31. doi: 10.1016/j.pnpbp.2012.07.020. Epub 2012 Aug 11.
  • The activation of the mu-opioid receptors (MOR) in the central nervous system has a proconvulsant effect and seizures are a common side effect of high doses of short acting opioids, like morphine or fentanyl. However, the correct assessment of the role of MOR blockade in the initiation and propagati
  • PMID 22918032

Japanese Journal

  • Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
  • WATANABE Yusuke,TAKECHI Kenshi,FUJIWARA Akinori,KAMEI Chiaki
  • Journal of pharmacological sciences 112(3), 282-289, 2010-03-20
  • NAID 80020902056
  • Anticonvulsant Effect of (RS)-1-Aminoindan-1,5-dicarboxylic Acid on Pentetrazol-Induced Kindled Seizures in Mice
  • Watanabe Yusuke,Kaida Yuko,Takechi Kenshi,Kamei Chiaki
  • Biological & Pharmaceutical Bulletin 33(4), 647-652, 2010
  • … The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures. … In order to induce kindling, pentetrazol at a dose of 40 mg/kg was injected intraperitoneally once every 48 h. … Behavioral and electroencephalographic (EEG) seizures were observed for 20 min following pentetrazol administration. …
  • NAID 130000248013

Related Links

Fundstellen zu "Pentetrazol" im Internet, an Universitäten und in der Literatur... ... Postkonvulsive Effekte nach Pentetrazol und deren Beeinflussung ... Klaus Haufe, 1965 ...
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Related Pictures

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respiratory stimulant, respiratory stimulants
  • 延髄に直接作用して呼吸興奮と血圧上昇作用を示す。臨床応用は限られる (SPC.272)
  • 過量:唾液分泌過多、悪心、嘔吐、不整脈、けいれん (SPC.272)
  • 頚動脈体や大動脈体および延髄の化学受容器を刺激して呼吸興奮を起こす。即効性で持続時間は短い (SPC.272)
  • 気道粘膜、食道および胃粘膜を刺激して反射的に呼吸興奮を起こす (SPC.272)
  • アルコール飲料、アンモニア
respiratory stimulants



ペンチレンテトラゾール pentylenetetrazol
  • GABA-A遮断





  • 漸進性、非同調的、間代性けいれん
  • てんかん脳波を誘発