癌原遺伝子産物c-Ets
WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- in favor of a proposition, opinion, etc.
- an argument in favor of a proposal
- in favor of (an action or proposal etc.); "a pro vote"
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- indicating the first or earliest or original; "`proto is a combining form in a word like `protolanguage that refers to the hypothetical ancestor of another language or group of languages"
- a gene that disposes normal cells to change into cancerous tumor cells (同)transforming_gene
PrepTutorEJDIC
- carbonの化学記号
- =professional
- 賛成論;賛成票(者) / 賛成して
- 蛋白(たんばく)質
UpToDate Contents
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English Journal
- Screening of transcription factors with transcriptional initiation activity.
- Zhang L, Yu H, Wang P, Ding Q, Wang Z.Author information Protein Science Key Laboratory of the Ministry of Education, Department of Pharmacology, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address: zhanglang08@mails.tsinghua.edu.cn.AbstractA majority of mammalian promoters are associated with CpG islands. CpG island promoters frequently lack common core promoter elements, such as the TATA box, and often have dispersed transcription start sites. The mechanism through which CpG island promoters are transcriptionally initiated remains unclear. We speculate that some transcription factors can direct transcription initiation by themselves. To test this hypothesis, we screened a variety of transcription factors to see whether they could initiate transcription. Most transcription factors, including specificity protein 1 (Sp1) and nuclear factor Y (NF-Y), showed little transcriptional initiation activity. However, nuclear respiratory factor 1 (NRF-1), the basic helix-loop-helix/leucine zipper (bHLH/ZIP) family of proteins and the E-twenty six (Ets) family of proteins had strong transcriptional activity. We further demonstrated that these transcription factors initiate dispersed transcription. Our studies provide perspectives to the mechanism of transcription initiation from CpG island promoters.
- Gene.Gene.2013 Nov 15;531(1):64-70. doi: 10.1016/j.gene.2013.07.054. Epub 2013 Aug 9.
- A majority of mammalian promoters are associated with CpG islands. CpG island promoters frequently lack common core promoter elements, such as the TATA box, and often have dispersed transcription start sites. The mechanism through which CpG island promoters are transcriptionally initiated remains un
- PMID 23933270
- Identification and dissection of a key enhancer mediating cranial neural crest specific expression of transcription factor, Ets-1.
- Barembaum M, Bronner ME.Author information Division of Biology, California Institute of Technology, MC 139-74, Pasadena, CA 91125 USA. Electronic address: mbaremba@caltech.edu.AbstractNeural crest cells form diverse derivatives that vary according to their level of origin along the body axis, with only cranial neural crest cells contributing to facial skeleton. Interestingly, the transcription factor Ets-1 is uniquely expressed in cranial but not trunk neural crest, where it functions as a direct input into neural crest specifier genes, Sox10 and FoxD3. We have isolated and interrogated a cis-regulatory element, conserved between birds and mammals, that drives reporter expression in a manner that recapitulates that of endogenous Ets-1 expression in the neural crest. Within a minimal Ets-1 enhancer region, mutation of putative binding sites for SoxE, homeobox, Ets, TFAP2 or Fox proteins results in loss or reduction of neural crest enhancer activity. Morpholino-mediated loss-of-function experiments show that Sox9, Pax7, Msx1/2, Ets-1, TFAP2A and FoxD3, all are required for enhancer activity. In contrast, mutation of a putative cMyc/E-box sequence augments reporter expression, consistent with this being a repressor binding site. Taken together, these results uncover new inputs into Ets-1, revealing critical links in the cranial neural crest gene regulatory network.
- Developmental biology.Dev Biol.2013 Oct 15;382(2):567-75. doi: 10.1016/j.ydbio.2013.08.009. Epub 2013 Aug 19.
- Neural crest cells form diverse derivatives that vary according to their level of origin along the body axis, with only cranial neural crest cells contributing to facial skeleton. Interestingly, the transcription factor Ets-1 is uniquely expressed in cranial but not trunk neural crest, where it func
- PMID 23969311
- CK2-mediated TEL2 phosphorylation augments nonsense-mediated mRNA decay (NMD) by increase of SMG1 stability.
- Ahn S, Kim J, Hwang J.Author information Graduate School for Biomedical Science and Engineering, Hanyang University, Seoul 133-791, South Korea.AbstractNonsense-mediated mRNA decay (NMD) is the best-characterized mRNA surveillance mechanism that degrades a premature-termination codon (PTC)-containing mRNA. During mammalian NMD, SMG1 and UPF1, key proteins in NMD, join at a PTC and form an SMG1-UPF1-eRF1-eRF3 (SURF) complex by binding UPF1 to eRF3 after PTC-recognition by the translating ribosome. Subsequently, UPF1 is phosphorylated after UPF1-SMG1 moves onto the downstream exon junction complex (EJC). However, the cellular events that induce UPF1 and SMG1 complex formation and increase NMD efficiency before PTC recognition remain unclear. Here, we show that telomere-maintenance 2 (TEL2) phosphorylation by casein-kinase 2 (CK2) increases SMG1 stability, which increases UPF1 phosphorylation and, ultimately, augments NMD. Inhibition of CK2 activity or downregulation of TEL2 impairs NMD. Intriguingly, loss of TEL2 phosphorylation reduces UPF1-bound PTC-containing mRNA and the formation of the SMG1-UPF1 complex. Thus, our results identify a new function of CK2-mediated TEL2 phosphorylation in a mammalian NMD.
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1829(10):1047-55. doi: 10.1016/j.bbagrm.2013.06.002. Epub 2013 Jul 3.
- Nonsense-mediated mRNA decay (NMD) is the best-characterized mRNA surveillance mechanism that degrades a premature-termination codon (PTC)-containing mRNA. During mammalian NMD, SMG1 and UPF1, key proteins in NMD, join at a PTC and form an SMG1-UPF1-eRF1-eRF3 (SURF) complex by binding UPF1 to eRF3 a
- PMID 23831331
Related Links
- "Proto-Oncogene Protein c-ets-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... This graph shows the total number of publications written about "Proto ...
- "Proto-Oncogene Protein c-ets-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... This graph shows the total number of publications written about "Proto ...
★リンクテーブル★
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- 英
- proto-oncogene protein c-Ets
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癌原遺伝子産物c-Ets-1
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癌原遺伝子産物c-Ets-2
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- 関
- oncogene product、oncoprotein
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