関: calcineurin、PP2B

WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphates

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蛋白(たんばく)質

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/30 08:34:43」(JST)

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Protein phosphatase 3, catalytic subunit, alpha isozyme is a protein that in humans is encoded by the PPP3CA gene.^[1]

References

^ "Entrez Gene: Protein phosphatase 3, catalytic subunit, alpha isozyme". Retrieved 2011-12-18.

UpToDate Contents

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1. 脊髄小脳変性症 the spinocerebellar ataxias
2. プロテインＳ欠乏症 protein s deficiency
3. プロテインＣ欠乏症 protein c deficiency
4. 第V因子ライデンと活性化プロテインC抵抗性 factor v leiden and activated protein c resistance
5. 肥大型心筋症：遺伝子変異および臨床遺伝子検査 hypertrophic cardiomyopathy gene mutations and clinical genetic testing

English Journal

Targeting Transient Receptor Potential Channels by MicroRNAs Drives Tumor Development and Progression.

Santoni G, Morelli MB, Santoni M, Nabissi M, Marinelli O, Amantini C.
Advances in experimental medicine and biology. 2020 ;1131()605-623.
Transient receptor potential (TRP) cation channel superfamily plays important roles in a variety of cellular processes such polymodal cellular sensing, adhesion, polarity, proliferation, differentiation and apoptosis. The expression of TRP channels is strictly regulated and their de-regulation can s
PMID 31646527

Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells.

Wang YX, Wang L, Zheng YM.
Advances in experimental medicine and biology. 2020 ;1131()471-487.
All seven canonical transient potential receptor (TRPC1-7) channel members are expressed in mammalian airway smooth muscle cells (ASMCs). Among this family, TRPC3 channel plays an important role in the control of the resting [Ca] and agonist-induced increase in [Ca]. This channel is significantly up
PMID 31646521

An Update to Calcium Binding Proteins.

Elíes J, Yáñez M, Pereira TMC, Gil-Longo J, MacDougall DA, Campos-Toimil M.
Advances in experimental medicine and biology. 2020 ;1131()183-213.
Ca binding proteins (CBP) are of key importance for calcium to play its role as a pivotal second messenger. CBP bind Ca in specific domains, contributing to the regulation of its concentration at the cytosol and intracellular stores. They also participate in numerous cellular functions by acting as
PMID 31646511

Japanese Journal

Regulation of the catalytic domain of protein phosphatase 1 by the terminal region of protein phosphatase 2B

WANG Bai J.,TANG Wei,ZHANG Peng,WEI Qun
The journal of biochemistry 151(3), 283-290, 2012-03-01
NAID 10031166067

Regulation of the catalytic domain of protein phosphatase 1 by the terminal region of protein phosphatase 2B

Wang Bai J.,Tang Wei,Zhang Peng [他]
Journal of Biochemistry 151(3), 283-290, 2012-03
NAID 40019186005

Interaction of Protein Phosphatase 1δ with Nucleophosmin in Human Osteoblastic Cells

Haneji Tatsuji,Teramachi Jumpei,Hirashima Kanji,Kimura Koji,Morimoto Hiroyuki
ACTA HISTOCHEMICA ET CYTOCHEMICA 45(1), 1-7, 2012
… Protein phosphorylation and dephosphorylation has been recognized as an essential mechanism in the regulation of cellular metabolism and function in various tissues. … Serine and threonine protein phosphatases (PP) are divided into four categories: PP1, PP2A, PP2B, and PP2C. … Anti-PP1δ antibody recognized a protein present in the nucleolar regions in Saos-2 cells. …
NAID 130001258485

「カルシニューリン」

PPP3CA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V
Identifiers
Aliases	PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha
External IDs	MGI: 107164 HomoloGene: 55497 GeneCards: 5530
Genetically Related Diseases
Disease Name	References
	[1]
Gene ontology
Molecular function	• calcium ion binding; • phosphoprotein phosphatase activity; • protein dimerization activity; • calmodulin-dependent protein phosphatase activity; • protein serine/threonine phosphatase activity; • metal ion binding; • calmodulin binding; • protein binding; • drug binding; • protein heterodimerization activity; • enzyme binding; • calcium-dependent protein serine/threonine phosphatase activity; • hydrolase activity;
Cellular component	• postsynapse; • cytoplasm; • cytosol; • membrane; • plasma membrane; • calcineurin complex; • nucleoplasm; • Z disc; • mitochondrion; • sarcolemma; • nucleus;
Biological process	• multicellular organismal response to stress; • negative regulation of insulin secretion; • protein import into nucleus; • transition between fast and slow fiber; • negative regulation of chromatin binding; • G1/S transition of mitotic cell cycle; • response to amphetamine; • protein dephosphorylation; • calcineurin-NFAT signaling cascade; • modulation of synaptic transmission; • positive regulation of sequence-specific DNA binding transcription factor activity; • stimulatory C-type lectin receptor signaling pathway; • response to calcium ion; • Fc-epsilon receptor signaling pathway; • cellular response to drug; • cardiac muscle hypertrophy in response to stress; • negative regulation of dendrite morphogenesis; • skeletal muscle fiber development; • positive regulation of cardiac muscle hypertrophy in response to stress; • excitatory postsynaptic potential; • positive regulation of NFAT protein import into nucleus; • innate immune response; • T cell activation; • cellular response to glucose stimulus; • calcium ion transport; • calcium-mediated signaling; • dephosphorylation; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
RNA expression pattern
	; ; ; ;
	More reference expression data
Orthologs
	5530
	19055
	ENSG00000138814
	ENSMUSG00000028161
	Q08209
	P63328
	NM_001130692; NM_000944; NM_001130691
	NM_001293622; NM_008913
	NP_000935.1; NP_001124163.1; NP_001124164.1
	NP_001280551.1; NP_032939.1
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: calcineurin, CN, CNR
同: プロテインホスファターゼ2B protein phosphatase 2B、カルシニュリン、カルシノイリン
関: IL-2、免疫抑制薬

[show details]

カルシニュリン : 約 90 件
カルシニューリン : 約 72,900 件
カルシノイリン : 20 件

Ca2+/カルモジュリン複合体依存性のセリン/スレオニン脱リン酸化酵素である。
サブユニットAとサブユニットBからなるヘテロダイマー。
免疫抑制薬の標的分子となりえて、例えばシクロスポリンAやFK506などのカルシニューリン阻害薬によりT細胞中のカルシニューリンが阻害されることでIL-2の発現が低下し、結果としてT細胞の増殖が妨げられ免疫抑制が起こる。

「PP2B」

　　[★]

プロテインホスファターゼ2B

関: calcineurin、protein phosphatase 2B

「プロテインホスファターゼ2B」

　　[★]

英: protein phosphatase 2B、PP2B
関: カルシニューリン

「phosphatase」

　　[★] ホスファターゼ、フォスファターゼ、脱リン酸化酵素、脱リン酸酵素

関: phosphohydrolase、phosphoric monoester hydrolase

「protein phosphatase」

　　[★] 蛋白質ホスファターゼ

[entrez-1] "Entrez Gene: Protein phosphatase 3, catalytic subunit, alpha isozyme". Retrieved 2011-12-18.

リンク元	「カルシニューリン」「PP2B」「プロテインホスファターゼ2B」
関連記事	「phosphatase」「protein phosphatase」

匿名

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案内

案内

protein phosphatase 2B