WordNet
- any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphates
English Journal
- Antioxidant activity of penta-oligogalacturonide, isolated from haw pectin, suppresses triglyceride synthesis in mice fed with a high-fat diet.
- Li T, Li S, Dong Y, Zhu R, Liu Y.Author information Department of Food Science, Liaoning University, Shenyang 110036, China. Electronic address: Ltp0401@126.com.AbstractTo expand application of hawthorn (Crataegus pinnatifida Bge) fruit, the antioxidant and anti-lipidemic effects of haw pectin penta-oligogalacturonide (HPPS) prepared from hawthorn fruit were investigated in vitro and in mice. HPPS exhibited concentration-dependent scavenging activities against superoxide anion, hydroxyl and DPPH radicals. Additionally, HPPS supplementation significantly enhanced the antioxidant enzyme activities of superoxide dismutase, catalase, glutathione peroxidase, increased the total antioxidant capacity and the levels of glutathione, but lowered the malondialdehyde content in the liver of high-fat fed mice. Furthermore, HPPS significantly decreased the TG levels, the activity and the mRNA and protein levels of glycerol 3-phosphate acyltransferase (GPAT) and phosphatidate phosphohydrolase (PAP) in mice livers. Moreover, liver steatosis of mice associated with diffuse hepatocyte ballooning induced by a high-fat diet was markedly improved by a dose of 300 mg/kg HPPS-consumption. The results revealed that HPPS might be applicable as a dietary supplement for the prevention of fatty liver and oxidative damage.
- Food chemistry.Food Chem.2014 Feb 15;145:335-41. doi: 10.1016/j.foodchem.2013.08.036. Epub 2013 Aug 16.
- To expand application of hawthorn (Crataegus pinnatifida Bge) fruit, the antioxidant and anti-lipidemic effects of haw pectin penta-oligogalacturonide (HPPS) prepared from hawthorn fruit were investigated in vitro and in mice. HPPS exhibited concentration-dependent scavenging activities against supe
- PMID 24128486
- The enzymes of human diphosphoinositol polyphosphate metabolism.
- Thomas MP, Potter BV.Author information Department of Pharmacy & Pharmacology, University of Bath, UK.AbstractDiphospho-myo-inositol polyphosphates have many roles to play, including roles in apoptosis, vesicle trafficking, the response of cells to stress, the regulation of telomere length and DNA damage repair, and inhibition of the cyclin-dependent kinase Pho85 system that monitors phosphate levels. This review focuses on the three classes of enzymes involved in the metabolism of these compounds: inositol hexakisphosphate kinases, inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinases and diphosphoinositol polyphosphate phosphohydrolases. However, these enzymes have roles beyond being mere catalysts, and their interactions with other proteins have cellular consequences. Through their interactions, the three inositol hexakisphosphate kinases have roles in exocytosis, diabetes, the response to infection, and apoptosis. The two inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinases influence the cellular response to phosphatidylinositol (3,4,5)-trisphosphate and the migration of pleckstrin homology domain-containing proteins to the plasma membrane. The five diphosphoinositol polyphosphate phosphohydrolases interact with ribosomal proteins and transcription factors, as well as proteins involved in membrane trafficking, exocytosis, ubiquitination and the proteasomal degradation of target proteins. Possible directions for future research aiming to determine the roles of these enzymes are highlighted.
- The FEBS journal.FEBS J.2014 Jan;281(1):14-33. doi: 10.1111/febs.12575. Epub 2013 Nov 5.
- Diphospho-myo-inositol polyphosphates have many roles to play, including roles in apoptosis, vesicle trafficking, the response of cells to stress, the regulation of telomere length and DNA damage repair, and inhibition of the cyclin-dependent kinase Pho85 system that monitors phosphate levels. This
- PMID 24152294
- Propranolol Restricts the Mobility of Single EGF-Receptors on the Cell Surface before Their Internalization.
- Otero C1, Linke M2, Sanchez P3, González A4, Schaap IA3.Author information 1Center for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello, Santiago, Chile ; Centro para el Desarrollo de la Nanociencia y Nanotecnologia, Santiago, Chile.2III. Physikalisches Institut, Faculty of Physics, Georg-August Universität, Göttingen, Germany.3III. Physikalisches Institut, Faculty of Physics, Georg-August Universität, Göttingen, Germany ; Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.4Departamento de Inmunología Clínica y Reumatología, Facultad de Medicina and Centro de Envejecimiento y Regeneración, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.AbstractThe epidermal growth factor receptor is involved in morphogenesis, proliferation and cell migration. Its up-regulation during tumorigenesis makes this receptor an interesting therapeutic target. In the absence of the ligand, the inhibition of phosphatidic acid phosphohydrolase activity by propranolol treatment leads to internalization of empty/inactive receptors. The molecular events involved in this endocytosis remain unknown. Here, we quantified the effects of propranolol on the mobility of single quantum-dot labelled receptors before the actual internalization took place. The single receptors showed a clear stop-and-go motion; their diffusive tracks were continuously interrupted by sub-second stalling events, presumably caused by transient clustering. In the presence of propranolol we found that: i) the diffusion rate reduced by 22 %, which indicates an increase in drag of the receptor. Atomic force microscopy measurements did not show an increase of the effective membrane tension, such that clustering of the receptor remains the likely mechanism for its reduced mobility. ii) The receptor got frequently stalled for longer periods of multiple seconds, which may signal the first step of the internalization process.
- PloS one.PLoS One.2013 Dec 9;8(12):e83086. doi: 10.1371/journal.pone.0083086.
- The epidermal growth factor receptor is involved in morphogenesis, proliferation and cell migration. Its up-regulation during tumorigenesis makes this receptor an interesting therapeutic target. In the absence of the ligand, the inhibition of phosphatidic acid phosphohydrolase activity by propranolo
- PMID 24349439
Japanese Journal
- Correlation between the Phosphohydrolase Activity of the Escherichia coli Orf135 (NudG) Protein and Mutation Suppression
- 環境変異原研究 = Genes and environment : the official journal of the Japanese Environmental Mutagen Society 29(2), 63-66, 2007-05-28
- NAID 110006279220
- Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
- Biochemical and Biophysical Research Communications 357(1), 212-217, 2007-05-25
- NAID 80018495723
- Correlation between the Phosphohydrolase Activity of the Escherichia coli Orf135 (NudG) Protein and Mutation Suppression
- Genes and Environment 29(2), 63-66, 2007
- NAID 130004481156
Related Links
- phosphohydrolase 【名】リン酸ヒドロラーゼ - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。 ... 英和・和英 対訳データオンライン検索 ...
- phosphohydrolase (plural phosphohydrolases) (biochemistry) Any enzyme that hydrolyzes an organic phosphate group Retrieved from "https://en.wiktionary.org/w/index.php?title=phosphohydrolase&oldid=21130633" Categories: ...
Related Pictures
★リンクテーブル★
「リン酸加水分解酵素」
- 英
- phosphohydrolase、phosphoric monoester hydrolase
- 関
- フォスファターゼ、ホスファターゼ、ホスホヒドロラーゼ、リン酸モノエステル加水分解酵素、リン酸モノエステルヒドロラーゼ
「phosphoric monoester hydrolase」
リン酸加水分解酵素、リン酸モノエステルヒドロラーゼ、リン酸モノエステル加水分解酵素、ホスファターゼ
「phosphatase」
[★] ホスファターゼ、フォスファターゼ、脱リン酸化酵素、脱リン酸酵素
「ホスホヒドロラーゼ」
「GTP phosphohydrolase」
「GTP phosphohydrolase activator」
「inositol 1,2-cyclic phosphate 2-phosphohydrolase」
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