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1. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
2. メキシレチンの主な副作用 major side effects of mexiletine
3. 早産児における非経口栄養 parenteral nutrition in premature infants
4. 変形性関節症の薬物療法に対する実験的アプローチ investigational approaches to the pharmacologic therapy of osteoarthritis
5. コーガン症候群 cogans syndrome

Comparative functional selectivity of imidafenacin and propiverine, antimuscarinic agents, for the urinary bladder over colon in conscious rats.

Muraki Y1.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2015 Nov;388(11):1171-8. doi: 10.1007/s00210-015-1155-9. Epub 2015 Jul 28.
Antimuscarinics are the first-line choice of treatment for overactive bladder (OAB). Imidafenacin distributes in the bladder more selectively than in the submaxillary gland and colon, and hence, this drug is considered more useful for OAB than other antimuscarinics. However, the examination of imida
PMID 26216447

Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats.

Nishijima S1, Sugaya K1, Kadekawa K1, Ashitomi K1, Ueda T2, Yamamoto H3.
International journal of urology : official journal of the Japanese Urological Association.Int J Urol.2015 Oct 27. doi: 10.1111/iju.12991. [Epub ahead of print]
OBJECTIVE: To investigate whether propiverine has a noradrenaline re-uptake inhibitor and whether it acts on the lumbosacral cord or the urethral wall. In addition, we aimed to examine the effect of propiverine on leak point pressure in rats.METHODS: A total of 72 female and 30 male rats were used t
PMID 26502799

Editorial Comment to Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats.

Saito M1, Shimizu S2.
International journal of urology : official journal of the Japanese Urological Association.Int J Urol.2015 Oct 25. doi: 10.1111/iju.13000. [Epub ahead of print]
PMID 26496860