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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/05 13:34:13」(JST)

Pranoprofen (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.^[1]

References

^ Akyol-Salman, İ.; Leçe-Sertöz, D.; Baykal, O. (2007). "Topical Pranoprofen 0.1% is As Effective Anti-Inflammatory and Analgesic Agent as Diclofenac Sodium 0.1% After Strabismus Surgery". Journal of Ocular Pharmacology and Therapeutics 23 (3): 280–283. doi:10.1089/jop.2006.108. PMID 17593012. edit

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Effect of textured eye drop bottles on the photostability of pranoprofen 0.1% ophthalmic solution.

Iwatsuka K1, Inada K, Ueoka H, Otsuka T, Maeda M, Yamaguchi M, Yasueda S.
Drug development and industrial pharmacy.Drug Dev Ind Pharm.2015 Sep;41(9):1526-31. doi: 10.3109/03639045.2014.971028. Epub 2015 Jul 21.
CONTEXT: Ophthalmic solutions are usually filled in a plastic bottle due to its durability and disposability. In Japan, photostability is one of the concerns for the quality control because an eye drop bottle must be a transparent container.OBJECTIVE: The present work studied the effect of textured
PMID 25308744

Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration.

Abrego G1, Alvarado H1, Souto EB2, Guevara B3, Bellowa LH4, Parra A1, Calpena A3, Garcia ML5.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2015 Feb 11. pii: S0939-6411(15)00042-9. doi: 10.1016/j.ejpb.2015.01.026. [Epub ahead of print]
Two optimized pranoprofen-loaded poly-l-lactic-co glycolic acid (PLGA) nanoparticles (PF-F1NPs; PF-F2NPs) have been developed and further dispersed into hydrogels for the production of semi-solid formulations intended for ocular administration. The optimized PF-NP suspensions were dispersed in fresh
PMID 25681744

Dose dependent cytotoxicity of pranoprofen in cultured human corneal endothelial cells by inducing apoptosis.

Li YH1, Wen Q, Fan TJ, Ge Y, Yu MM, Sun LX, Zhao Y.
Drug and chemical toxicology.Drug Chem Toxicol.2015 Jan;38(1):16-21. doi: 10.3109/01480545.2014.900067. Epub 2014 Mar 18.
Pranoprofen (PPF), a non-steroidal anti-inflammatory drugs (NSAIDs), is often used in keratitis treatment in clinic. Several studies have assessed in vitro the cytotoxicity of topical NSAIDs to corneal epithelial cells due to its importance for predicting human corneal toxicity. Damage by cytotoxic
PMID 24641202

Cytotoxicity of Topical Medications Used for Infection and Inflammation Control after Cataract Surgery in Cultured Corneal Endothelial Cells

AYAKI MASAHIKO,TAGUCHI YOKO,SODA MITSUTAKA,YAGUCHI SHIGEO,IWASAWA ATSUO,KOIDE RYOHEI
Biocontrol Science 15(3), 97-102, 2010
… A range of commercially available antibiotic and anti-inflammatory ophthalmic solutions used postoperatively, namely levofloxacin, moxifloxacin, gatifloxacin, cefmenoxime, diclofenac, bromfenac, pranoprofen, betamethasone, and fluoromethorone, were assessed by using human corneal endothelial cells (HCECs). …
NAID 130000406475

Pranoprofen
Systematic (IUPAC) name
	2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Registry Number	52549-17-4
ATC code	S01BC09
PubChem	CID: 4888
ChemSpider	4719
UNII	2R7O1ET613
ChEMBL	CHEMBL367463
Chemical data
Formula	C15H13NO3
Molecular mass	255.26 g/mol
	SMILES CC(C1=CC2=C(C=C1)OC3=C(C2)C=CC=N3)C(=O)O ;
	InChI InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18) ; Key:TVQZAMVBTVNYLA-UHFFFAOYSA-N ;
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