プラリドキシム
WordNet
- a salt or ester of hydriodic acid
PrepTutorEJDIC
- ヨウ化物
UpToDate Contents
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English Journal
- Benefit of nanocarrier of magnetic magnesium in rat malathion-induced toxicity and cardiac failure using non-invasive monitoring of electrocardiogram and blood pressure.
- Mohammadi H, Karimi G, Seyed Mahdi Rezayat, Ahmad Reza Dehpour, Shafiee H, Nikfar S, Baeeri M, Sabzevari O, Abdollahi M.SourceFaculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran, Medical Toxicology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
- Toxicology and industrial health.2011 Jun;27(5):417-29. Epub 2011 Feb 10.
- Medical management in acute organophosphate (OP) poisoning is not always successful because of tissue hypoxia which results in a reduction of heart contractility and cell damage. This study reports improvement of malathion (MAL)-induced cardiac failure by a nanocarrier of magnetic isotope of Mg (PMC
- PMID 21310777
- Montmorillonite Functionalized with Pralidoxime As a Material for Chemical Protection against Organophosphorous Compounds.
- Bromberg L, Straut CM, Centrone A, Wilusz E, Hatton TA.SourceDepartment of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
- ACS applied materials & interfaces.2011 May 25;3(5):1479-84. Epub 2011 Apr 13.
- Montmorillonite K-10 functionalized with α-nucleophilic 2-pralidoxime (PAM) and its zwitterionic oximate form (PAMNa) is introduced as a versatile material for chemical protection against organophosphorous (OP) compounds such as pesticides and chemical warfare agents (CWA). Upon inclusion into the
- PMID 21438604
Japanese Journal
- Chinese dumpling scare hits Japan-a case of methamidophos food poisoning
- Sumi Yuka,Oode Yasumasa,Tanaka Hiroshi
- The Journal of Toxicological Sciences 33(4), 485-486, 2008-10-01
- … We started intravenous treatment with pralidoxime iodide, atropine sulfate, and midazolam. …
- NAID 110006950528
- IMMUNOLOGICAL CONTROL OF DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT : EFFECT OF LOCAL ANAPHYLAXIS ON THE INTESTINAL ABSORPTION OF LOW MOLECULAR WEIGHT DRUGS IN THE RAT
- YAMAMOTO AKIRA,UTSUMI ERIKO,HAMAURA TAKESHI,NAKAMURA JUNZO,HASHIDA MITSURU,SEZAKI HITOSHI
- Journal of pharmacobio-dynamics 8(10), 830-840, 1985-10
- … Under this condition, intestinal absorption of caffeine, phenylbutazone, and bromthymol blue (BTB) significantly decreased in ovalbumin-immunized rats compared with the control, whereas no significant effect was noted in the intestinal absorption of salicylic acid, quinine, pralidoxime iodide (2-PAM), tetracycline, and phenol red. …
- NAID 110003637854
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- Pralidoxime Iodide and Chloride Pralidoxime or 2-PAM, usually as the chloride or methiodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to combat ...
Related Pictures
★リンクテーブル★
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- 英
- pralidoxime
- 商
- パム静注, Protopam
- 同
- プラリドキシムヨウ化メチル、2-pyridine aldoxime methiodide 2-PAM PAM、ヨウ化プラリドキシム pralidoxime iodide
- 関
- 有機リン剤中毒、コリンエステラーゼ阻害薬
概念
- 有機リン化合物中毒治療
- コリンエステラーゼを再活性化させる。
薬効薬理
- パム静注500mg
- (1) マウスにパラチオン他7種類の有機リン剤を投与した実験において、各臓器のChE活性を回復させることが認められている。1)
- (2) マウスにパラチオン他8種類の有機リン剤を投与した実験において、LD50値が上昇することが認められている。2)
- (3) ウサギにパラチオン他8種類の有機リン剤を投与した実験において、血液中のChE活性を回復させることが認められている。2)
- (4) ヒト血液を用いたin vitroの実験において、スミチオン他9種類の有機リン剤によって阻害されたChE活性を回復させることが認められている。3)
添付文書
- http://www.info.pmda.go.jp/go/pack/3929401A1035_3_04/3929401A1035_3_04?view=body
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- 関
- I、I2、iodine、iodo