WordNet

a toxic colorless flammable liquid organic base with a disagreeable odor; usually derived from coal

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New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM.SourceNIH COBRE Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT 59812, USA.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2009 Sep 1;19(17):5101-4. Epub 2009 Jul 10.
The preparation of a series of monoquaternary pyridinium oximes bearing either a heterocyclic side chain or a functionalized aliphatic side chain and the corresponding in vitro evaluation for reactivation of paraoxon-inhibited electric eel acetylcholinesterase (EeAChE) and recombinant human acetylch
PMID 19640713

Arima H, Sobue K, So M, Morishima T, Ando H, Katsuya H.SourceDepartment of Anesthesia and Critical Care, Okazaki City Hospital, Okazaki, Japan. arima@sb.starcat.ne.jp
Journal of toxicology. Clinical toxicology.J Toxicol Clin Toxicol.2003;41(1):67-70.
Parkinsonism is a rare complication in patients with organophosphate poisoning. To date there have been two cases of transient parkinsonism after acute and severe cholinergic crisis, both of which were successfully treated using amantadine, an anti-parkinsonism drug. We report on an 81-year-old woma
PMID 12645970

RADIOSENSITIZATION BY DIMETHYLBENZANTHRACENE, DIPHENYLCYCLOPROPENONE AND AMINOANTHRAQUINONES

ICHIKAWA Shoji,GOTO Takeshi,UMETSU Noriharu
Journal of toxicological sciences 20(2), 143-148, 1995-05-25
… The antidotal action of atropine sulfate and 2-pyridine aldoxime methiodide (2-PAM) against poisoning attributable to the new procarbamate insecticide benfuracarb [ethyl N-[2, 3-dihydro-2, 2-dimethylbenzofuran-7-yloxycarbonyl(methyl)aminothio]-N-isopropyl-β-alaninate] was compared utilizing rats as our experimental model. …
NAID 110001814813

STUDIES ON THE THERAPEUTIC EFFECT OF 2-PYRIDINE ALDOXIME METHIODIDE (2-PAM) IN MAMMALS FOLLOWING ORGANOPHOSPHORUS COMPOUND-POISONING (REPORT III):DISTRIBUTION AND ANTIDOTAL EFFECT OF 2-PAM IN RATS

UEHARA Sachiko,HIROMORI Toshihiko,ISOBE Naohiko,SUZUKI Takashi,KATO Terushige,MIYAMOTO Junshi
Journal of toxicological sciences 18(4), 265-275, 1993-11-25
… The metabolic fate of 2-PAM and its antidotal effect on organophosphorus compound poisoning in rats were studied. … When ^<14>C-2-PAM was administered intravenously, the amount of ^<14>C reaching the brain was small. … Following administration by intramedullary injection, ^<14>C was present in high concentrations in the brain, and 72-90% of the ^<14>C present in the brain corresponded to the unchanged form of 2-PAM. …
NAID 110001805349