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any of a group of viruses that can cause pox diseases in vertebrates

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/29 21:51:13」(JST)

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Poxviridae is a family of viruses. Human, vertebrates, and arthropods serve as natural hosts. There are currently 69 species in this family, divided among 28 genera, which are divided into two subfamilies. Diseases associated with this family include smallpox.^[1]^[2]

Four genera of poxviruses may infect humans: orthopoxvirus, parapoxvirus, yatapoxvirus, molluscipoxvirus. Orthopox: smallpox virus (variola), vaccinia virus, cowpox virus, monkeypox virus; Parapox: orf virus, pseudocowpox, bovine papular stomatitis virus; Yatapox: tanapox virus, yaba monkey tumor virus; Molluscipox: molluscum contagiosum virus (MCV).^[3] The most common are vaccinia (seen on Indian subcontinent) and molluscum contagiosum, but monkeypox infections are rising (seen in west and central African rainforest countries). Camelpox is a disease of camels caused by a virus of the family Poxviridae, subfamily Chordopoxvirinae, and the genus Orthopoxvirus. It causes skin lesions and a generalized infection. Approximately 25% of young camels that become infected will die from the disease, while infection in older camels is generally more mild.

Structure

A) Electron micrograph of poxvirus particles in synovium of a big brown bat, northwestern United States. B) Negative staining of poxvirus particles in cell culture supernatant. Scale bar = 100 nm.

Poxviridae viral particles (virions) are generally enveloped (external enveloped virion- EEV), though the intracellular mature virion (IMV) form of the virus, which contains different envelope, is also infectious. They vary in their shape depending upon the species but are generally shaped like a brick or as an oval form similar to a rounded brick because they are wrapped by the endoplasmic reticulum. The virion is exceptionally large, its size is around 200 nm in diameter and 300 nm in length and carries its genome in a single, linear, double-stranded segment of DNA.^[4] By comparison, Rhinovirus is 1/10 as large as a typical Poxviridae virion.^[5]

Genus	Structure	Capsid	Genomic Arrangement	Genomic Segmentation
Betaentomopoxvirus	Ovoid	Enveloped	Linear	Monopartite
Yatapoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Cervidpoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Gammaentomopoxvirus	Ovoid	Enveloped	Linear	Monopartite
Leporipoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Suipoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Molluscipoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Crocodylidpoxvirus	Ovoid	Enveloped	Linear	Monopartite
Alphaentomopoxvirus	Ovoid	Enveloped	Linear	Monopartite
Capripoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Orthopoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Avipoxvirus	Brick-shaped	Enveloped	Linear	Monopartite
Parapoxvirus	Ovoid	Enveloped	Linear	Monopartite

Replication

Replication of the poxvirus involves several stages. The first thing the virus does is to bind to a receptor on the host cell surface; the receptors for the poxvirus are thought to be glycosaminoglycans (GAGs). After binding to the receptor, the virus enters the cell where it uncoats. Uncoating of the virus is a two step process. Firstly the outer membrane is removed as the particle enters the cell; secondly the virus particle (without the outer membrane) fuses with the cellular membrane to release the core into the cytoplasm. The pox viral genes are expressed in two phases. The early genes encode the non-structural protein, including proteins necessary for replication of the viral genome, and are expressed before the genome is replicated. The late genes are expressed after the genome has been replicated and encode the structural proteins to make the virus particle. The assembly of the virus particle occurs in five stages of maturation that lead to the final exocytosis of the new enveloped virion. After the genome has been replicated, the immature virion (IV) assembles the A5 protein to create the intracellular mature virion (IMV). The protein aligns and the brick-shaped envelope of the intracellular enveloped virion (IEV). These IEV particles are then fused to the cell plasma to form the cell-associated enveloped virion (CEV). Finally, the CEV encounters the microtubules and the virion prepares to exit the cell as an extracellular enveloped virion (EEV). The assembly of the virus particle occurs in the cytoplasm of the cell and is a complex process that is currently being researched to understand each stage in more depth. Considering the fact that this virus is large and complex, replication is relatively quick taking approximately 12 hours until the host cell dies by the release of viruses.

The replication of poxvirus is unusual for a virus with double-stranded DNA genome (dsDNA) because it occurs in the cytoplasm,^[6] although this is typical of other large DNA viruses.^[7] Poxvirus encodes its own machinery for genome transcription, a DNA dependent RNA polymerase,^[8] which makes replication in the cytoplasm possible. Most dsDNA viruses require the host cell's DNA-dependent RNA polymerase to perform transcription. These host DNA are found in the nucleus, and therefore most dsDNA viruses carry out a part of their infection cycle within the host cell's nucleus.

Genus	Host Details	Tissue Tropism	Entry Details	Release Details	Replication Site	Assembly Site	Transmission
Betaentomopoxvirus	Lepidoptera insects; orthoptera insects	Hemocytes; fat bodies	Glycosaminoglycans	Lysis; budding; occlusion	Cytoplasm	Cytoplasm	Unknown
Yatapoxvirus	Monkeys; baboons	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Contact; insects
Cervidpoxvirus	Deer	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Unknown
Gammaentomopoxvirus	Insects	Hemocytes; fat bodies	Glycosaminoglycans	Lysis; budding; occlusion	Cytoplasm	Cytoplasm	Unknown
Leporipoxvirus	Lagomorph; squirrels	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Arthropods; contact
Suipoxvirus	Swine	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Unknown
Molluscipoxvirus	Humans	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Sex; contact
Crocodylidpoxvirus	Crocodiles	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Unknown
Alphaentomopoxvirus	Monkeys; baboons	None	Glycosaminoglycans	Lysis; budding; occlusion	Cytoplasm	Cytoplasm	Contact; insects
Capripoxvirus	Sheep; goat; cattle	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Arthropods; contact
Orthopoxvirus	Humans; mammals	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Variola virus; Respiratory; contact; zoonosis
Avipoxvirus	Birds	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Arthropods; aerosol
Parapoxvirus	Humans; mammals	None	Glycosaminoglycans	Lysis; budding	Cytoplasm	Cytoplasm	Zoonosis; contact

Evolution

The ancestor of the poxviruses is not known but structural studies suggest it may have been an adenovirus or a species related to both the poxviruses and the adenoviruses.^[9]

Based on the genome organisation and DNA replication mechanism it seems that phylogenetic relationships may exist between the rudiviruses (Rudiviridae) and the large eukaryal DNA viruses: the African swine fever virus (Asfarviridae), Chlorella viruses (Phycodnaviridae) and poxviruses (Poxviridae).^[10]

The mutation rate in these genomes has been estimated to be 0.9-1.2 x 10⁻⁶ substitutions per site per year.^[11] A second estimate puts this rate at 0.5-7 × 10⁻⁶ nucleotide substitutions per site per year.^[12] A third estimate places the rate at 4-6 × 10⁻⁶.^[13]

The last common ancestor of the extant poxviruses that infect vertebrates existed 0.5 million years ago. The genus Avipoxvirus diverged from the ancestor 249 ± 69 thousand years ago. The ancestor of the genus Orthopoxvirus was next to diverge from the other clades at 0.3 million years ago. A second estimate of this divergence time places this event at 166,000 ± 43,000 years ago.^[12] The division of the Orthopox into the extant genera occurred ~14,000 years ago. The genus Leporipoxvirus diverged ~137,000 ± 35,000 years ago. This was followed by the ancestor of the genus Yatapoxvirus. The last common ancestor of the Capripoxvirus and Suipoxvirus diverged 111,000 ± 29,000 years ago.

An isolate from a fish - Salmon Gill Poxvirus - appears to be the earliest branch in the Chordopoxvirinae.^[14]

Smallpox

The date of the appearance of smallpox is not settled. It most likely evolved from a rodent virus between 68,000 and 16,000 years ago.^[15]^[16] The wide range of dates is due to the different records used to calibrate the molecular clock. One clade was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim minor (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago.

A second estimate has placed the separation of variola from Taterapox at 3000–4000 years ago.^[13] This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. However if the mutation rate is assumed to be similar to that of the herpesviruses the divergence date between variola from Taterapox has been estimated to be 50,000 years ago.^[13] While this is consistent with the other published estimates it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed.

Taxonomy

Group: dsDNA

Order: Unassigned

Family: Poxviridae
- Sub-Family: Chordopoxvirinae
  - Genus: Avipoxvirus
    
    Canarypox virus
    
    Fowlpox virus
    
    Juncopox virus
    
    Mynahpox virus
    
    Pigeonpox virus
    
    Psittacinepox virus
    
    Quailpox virus
    
    Sparrowpox virus
    
    Starlingpox virus
    
    Turkeypox virus
  - Genus: Capripoxvirus
    
    Goatpox virus
    
    Lumpy skin disease virus
    
    Sheeppox virus
  - Genus: Cervidpoxvirus
    
    Mule deerpox virus
  - Genus: Crocodylidpoxvirus
    
    Nile crocodilepox virus
  - Genus: Leporipoxvirus
    
    Hare fibroma virus
    
    Myxoma virus
    
    Rabbit fibroma virus
    
    Squirrel fibroma virus
  - Genus: Molluscipoxvirus
    
    Molluscum contagiosum virus
  - Genus: Orthopoxvirus
    
    Camelpox virus
    
    Cowpox virus
    
    Ectromelia virus
    
    Monkeypox virus
    
    Raccoonpox virus
    
    Skunkpox virus
    
    Taterapox virus
    
    Vaccinia virus
    
    Variola virus
    
    Volepox virus
  - Genus: Parapoxvirus
    
    Bovine papular stomatitis virus
    
    Orf virus
    
    Parapoxvirus of red deer in New Zealand
    
    Pseudocowpox virus
  - Genus: Suipoxvirus
    
    Swinepox virus
  - Genus: Unassigned
    
    Squirrelpox virus
  - Genus: Yatapoxvirus
    
    Tanapox virus
    
    Yaba monkey tumor virus
- Sub-Family: Entomopoxvirinae
  - Genus: Alphaentomopoxvirus
    
    Anomala cuprea entomopoxvirus
    
    Aphodius tasmaniae entomopoxvirus
    
    Demodema bonariensis entomopoxvirus
    
    Dermolepida albohirtum entomopoxvirus
    
    Figulus sublaevis entomopoxvirus
    
    Geotrupes sylvaticus entomopoxvirus
    
    Melolontha melolontha entomopoxvirus
  - Genus: Betaentomopoxvirus
    
    Acrobasis zelleri entomopoxvirus
    
    Adoxophyes honmai entomopoxvirus
    
    Amsacta moorei entomopoxvirus
    
    Arphia conspersa entomopoxvirus
    
    Choristoneura biennis entomopoxvirus
    
    Choristoneura conflicta entomopoxvirus
    
    Choristoneura diversuma entomopoxvirus
    
    Choristoneura fumiferana entomopoxvirus
    
    Choristoneura rosaceana entomopoxvirus
    
    Chorizagrotis auxiliaris entomopoxvirus
    
    Heliothis armigera entomopoxvirus
    
    Locusta migratoria entomopoxvirus
    
    Mythimna separata entomopoxvirus
    
    Oedaleus senegalensis entomopoxvirus
    
    Operophtera brumata entomopoxvirus
    
    Schistocerca gregaria entomopoxvirus
  - Genus: Gammaentomopoxvirus
    
    Aedes aegypti entomopoxvirus
    
    Camptochironomus tentans entomopoxvirus
    
    Chironomus attenuatus entomopoxvirus
    
    Chironomus luridus entomopoxvirus
    
    Chironomus plumosus entomopoxvirus
    
    Goeldichironomus holoprasinus entomopoxvirus
  - Genus: Unassigned
    
    Diachasmimorpha entomopoxvirus
    
    Melanoplus sanguinipes entomopoxvirus 'O'

^[2]

The name of the family, Poxviridae, is a legacy of the original grouping of viruses associated with diseases that produced poxes in the skin. Modern viral classification is based on phenotypic characteristics; morphology, nucleic acid type, mode of replication, host organisms, and the type of disease they cause. The smallpox virus remains as the most notable member of the family.

The species in the subfamily Chordopoxvirinae infect vertebrates and those in the subfamily Entomopoxvirinae infect insects. There are 10 recognised genera in the Chordopoxvirinae and 3 in the Entomopoxvirinae. Both subfamiles also contain a number of unclassified species for which new genera may be created in the future. Cotia virus is an unusual virus that may belong to a new genus.^[17]

Notes

The GC-content of these genomes differs considerably.^[18] Avipoxvirus, Capripoxvirus, Cervidpoxvirus, Orthopoxvirus, Suipoxvirus, Yatapoxvirus and one Entomopox genus (Betaentomopoxvirus) along with several other unclassified Entomopoxviruses have a low G+C content while others - Molluscipoxvirus, Orthopoxvirus, Parapoxvirus and some unclassified Chordopoxvirus - have a relatively high G+C content. The reasons for these differences are not known.

Phylogenetic analysis of 26 Chordopoxviruses genomes has shown that the central region of the genome is conserved and contains ~90 genes.^[19] The termini in contrast are not conserved between species. Of this group Avipoxvirus is the most divergent. The next most divergent is Molluscipoxvirus. Capripoxvirus, Leporipoxvirus, Suipoxvirus and Yatapoxvirus genera cluster together: Capripoxvirus and Suipoxvirus share a common ancestor and are distinct from the genus Orthopoxvirus. Within the Othopoxvirus genus Cowpox virus strain Brighton Red, Ectromelia virus and Monkeypox virus do not group closely with any other member. Variola virus and Camelpox virus form a subgroup. Vaccinia virus is most closely related to CPV-GRI-90. ᾙἨἤᾐᾜἈ

Vaccinia virus

The prototypial poxvirus is vaccinia virus, known for its role as the active agent in the eradication of smallpox. The vaccinia virus is an effective tool for foreign protein expression, as it elicits a strong host immune-response. The vaccinia virus enters cells primarily by cell fusion, although currently the receptor responsible is unknown.

Vaccinia contains three classes of genes: early, intermediate and late. These genes are transcribed by viral RNA polymerase and associated transcription factors. Vaccinia replicates its genome in the cytoplasm of infected cells, and after late-stage gene expression undergoes virion morphogenesis, which produces IMV contained within an envelope membrane. The exact origin of the envelope membrane is still unknown. The IMV is then transported to the Golgi apparatus where it is wrapped with an additional two membranes, becoming the Intracellular Enveloped Virus (IEV). The IEV is transported along cytoskeletal microtubules to reach the cell periphery, where it fuses with the plasma membrane to become the Cell-associated Enveloped Virus (CEV). This triggers actin tails on cell surfaces or is released as EEV.

History

Diseases caused by pox viruses, especially smallpox, have been known about for centuries. One of the earliest suspected cases is that of Egyptian pharaoh Ramses V who is thought to have died from smallpox circa 1150 years BCE.^[20]^[21] Smallpox was thought to have been transferred to Europe around the early 8th century and then to the Americas in the early 16th century. It is widely accepted that the main defeat of the Aztecs was due to a smallpox epidemic and within two years over 3.2 million Aztecs died. This death toll can be attributed to the American population's complete lack of sensitization to the virus as children. A century after Edward Jenner showed that the less potent cow pox could be used to effectively vaccinate against the more deadly smallpox, a worldwide effort to vaccinate everyone against smallpox began with the ultimate goal to rid the world of the plague-like epidemic. The last case of endemic smallpox occurred in Somalia in 1977. Extensive searches over two years detected no further cases, and in 1979 the World Health Organization (WHO) declared the disease officially eradicated. In 1986, all virus samples were destroyed or transferred to two approved WHO reference labs: at the headquarters of the federal Centers for Disease Control and Prevention (the C.D.C.) in Atlanta, Georgia (the United States) and at the Institute of Virus Preparations in Moscow.^[22] Post September 11, 2001 the American and UK governments have had increased concern over the use of smallpox, or a smallpox like disease, in bio-terrorism.

References

^ "Viral Zone". ExPASy. Retrieved 15 June 2015.
^ ^a ^b ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.
^ "Pathogenic Molluscum Contagiosum Virus Sequenced". Antiviral Agents Bulletin (Biotechnology Information Institute): 196–7. August 1996. Retrieved 2006-07-16.
^ International Committee on Taxonomy of Viruses (2004-06-15). "ICTVdb Descriptions: 58. Poxviridae". Retrieved 2005-02-26.
^ How Big is a ... ? at Cells Alive!. Retrieved 2005-02-26.
^ Mutsafi, Y; Zauberman, N; Sabanay, I; Minsky, A (30 Mar 2010). "Vaccinia-like cytoplasmic replication of the giant Mimivirus". Proceedings of the National Academy of Sciences USA 107 (13): 5978–82. doi:10.1073/pnas.0912737107. PMC 2851855. PMID 20231474. .
^ Racaniello, Vincent (4 March 2014). "Pithovirus: Bigger than Pandoravirus with a smaller genome". Virology Blog. Retrieved 4 March 2014.
^ National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. "DNA-dependent RNA polymerase rpo35 (Vaccinia virus)". National Center for Biotechnology Information (NCBI), NIH, Bethesda, MD, USA.
^ Bahar, MW; Graham, SC; Stuart, DI; Grimes, JM (2011). "Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13". Structure 19 (7): 1011–1020. doi:10.1016/j.str.2011.03.023. PMC 3136756. PMID 21742267.
^ Prangishvili, D; Garrett, RA (2004). "Exceptionally diverse morphotypes and genomes of crenarchaeal hyperthermophilic viruses". Biochem Soc Trans 32 (2): 204–208. doi:10.1042/bst0320204.
^ Babkin IV, Shchelkunov SN (2006) The time scale in poxvirus evolution. Mol Biol (Mosk) 40(1):20-24
^ ^a ^b Babkin, IV; Babkina, IN (2011). "Molecular dating in the evolution of vertebrate poxviruses". Intervirology 54 (5): 253–260. doi:10.1159/000320964. PMID 21228539.
^ ^a ^b ^c Hughes, AL; Irausquin, S; Friedman, R (2010). "The evolutionary biology of poxviruses". Infect Genet Evol 10 (1): 50–59. doi:10.1016/j.meegid.2009.10.001. PMC 2818276. PMID 19833230.
^ Gjessing MC, Yutin N, Tengs T, Senkevich T, Koonin E, Rønning HP, Alarcon M, Ylving S, Lie KI, Saure B, Tran L, Moss B, Dale OB (2015) Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae. J Virol 89(18):9348-9867. doi: 10.1128/JVI.01174-15
^ Esposito, JJ; Sammons, SA; Frace, AM; Osborne, JD; Olsen-Rasmussen, M; Zhang, M; Govil, D; Damon, IK; et al. (Aug 2006). "Genome sequence diversity and clues to the evolution of variola (smallpox) virus". Science 313 (5788): 807–812. doi:10.1126/science.1125134. PMID 16873609.
^ Li, Y; Carroll, DS; Gardner, SN; Walsh, MC; Vitalis, EA; Damon, IK (2007). "On the origin of smallpox: correlating variola phylogenics with historical smallpox records". Proc Natl Acad Sci USA 104 (40): 15787–15792. doi:10.1073/pnas.0609268104. PMC 2000395. PMID 17901212.
^ Afonso PP, Silva PM, Schnellrath LC, Jesus DM, Hu J, Yang Y, Renne R, Attias M, Condit RC, Moussatché N, Damaso CR (2012) Biological characterization and next-generation genome sequencing of the unclassified Cotia virus SPAn232 (Poxviridae). J Virol
^ Roychoudhury, S; Pan, A; Mukherjee, D (2011). "Genus specific evolution of codon usage and nucleotide compositional traits of poxviruses". Virus Genes 42 (2): 189–199. doi:10.1007/s11262-010-0568-2.
^ Gubser, C; Hué, S; Kellam, P; Smith, GL (2004). "Poxvirus genomes: a phylogenetic analysis". J Gen Virol 85 (1): 105–117. doi:10.1099/vir.0.19565-0. PMID 14718625.
^ Hopkins, Donald R. (2002) [1983]. The greatest killer: smallpox in history, with a new introduction. University of Chicago Press. p. 15. By special permission of the late President Anwar el Sadat, I was allowed to examine the front upper half of Ramses V's unwrapped mummy in the Cairo Museum in 1979. …Inspection of the mummy revealed a rash of elevated "pustules," each about two to four millimeters in diameter, …(An attempt to prove that this rash was caused by smallpox by electron-microscopic examination of tiny pieeces of tissue that had fallen on the shroud was unsuccessful. I was not permitted to excise one of the postules.) …The appearance of the larger postules and the apparent distribution of the rash are similar to smallpox rashes I have seen in more recent victims
^ Date of Ramses V's death derived from the Encyclopedia of Ancient Egypt, Margaret Bunson (New York: Facts On File, 2002) ISBN 0816045631 p.337.
^ Henderson, D. A.; Inglesby, Thomas V.; Bartlett, John G.; Ascher, Michael S.; Eitzen, Edward; Jahrling, Peter B.; Hauer, Jerome; Layton, Marcelle; McDade, Joseph; Osterholm, Michael T.; O'Toole, Tara; Parker, Gerald; Perl, Trish; Russell, Philip K.; Tonat, Kevin; For The Working Group On Civilian Biodefense (1999). "Smallpox as a Biological Weapon: Medical and Public Health Management". JAMA: the Journal of the American Medical Association 281 (22): 2127–37. doi:10.1001/jama.281.22.2127. PMID 10367824.

External links

Electron micrographs of Orthopoxvirus and Parapoxvirus Genera, including the smallpox virus, have been collected by the International Committee on Taxonomy of Viruses in their Poxviridae picture gallery.
Buller, R. Mark L.; Palumbo, Gregory J. (1991). "Poxvirus Pathogenesis". Microbiology and Molecular Biology Reviews 55 (1): 80–122. PMC 372802. PMID 1851533.
Detailed genomic and bioinformatic information on Poxviruses on NIH-funded database.
NCBI Taxonomy Page.
Poxviridae at the Viral Bioinformatics Resource Center.
Poxviridae Genomes database search results from the Poxvirus Bioinformatics Resource Center.
Viralzone: Poxviridae
ICTV
Virus Pathogen Database and Analysis Resource (ViPR): Poxviridae

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Related Pictures

★リンクテーブル★

リンク元	「LLCMK2細胞」「ポックスウイルス」「Poxviridae」
拡張検索	「molluscipoxvirus」「leporipoxvirus」「entomopoxvirus」「parapoxvirus」「poxvirus officinale」

「LLCMK2細胞」

Poxviruses
Virus classification
Group:	Group I (dsDNA)
Order:	Unassigned
Family:	Poxviridae
Genera
	Subfamily Chordopoxvirinae; Avipoxvirus; Capripoxvirus; Cervidpoxvirus; Crocodylipoxvirus; Leporipoxvirus; Molluscipoxvirus; Orthopoxvirus; Parapoxvirus; Suipoxvirus; Yatapoxvirus Subfamily Entomopoxvirinae; Alphaentomopoxvirus; Betaentomopoxvirus; Gammaentomopoxvirus;

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英: LLCMK2 cell

サル腎上皮細胞

種：monkey, rhesus
組織：kidney

ウイルス感受性：astrovirus、enterovirus、influenza A virus、influenza B virus、myxovirus、parainfluenza、parainfluenza、parainfluenza、poliovirus、poliovirus、poliovirus、poxvirus、rhinovirus、rotavirus

「ポックスウイルス」

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英: poxvirus
関: 痘瘡ウイルス、ポック形成、ポックスウイルス科

「Poxviridae」

　　[★] ポックスウイルス科

関: poxvirus

「molluscipoxvirus」

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モルシポックスウイルス、伝染性軟属腫ウイルス

関: molluscum contagiosum virus

「leporipoxvirus」

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レポリポックスウイルス、ウサギポックスウイルス

「entomopoxvirus」

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エントモポックスウイルス

関: Entomopoxvirinae

「parapoxvirus」

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パラポックスウイルス

「poxvirus officinale」

　　[★] ワクシニアウイルス

[ViralZone-1] "Viral Zone". ExPASy. Retrieved 15 June 2015.

[ICTV-2] ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.

[3] "Pathogenic Molluscum Contagiosum Virus Sequenced". Antiviral Agents Bulletin (Biotechnology Information Institute): 196–7. August 1996. Retrieved 2006-07-16.

[4] International Committee on Taxonomy of Viruses (2004-06-15). "ICTVdb Descriptions: 58. Poxviridae". Retrieved 2005-02-26.

[5] How Big is a ... ? at Cells Alive!. Retrieved 2005-02-26.

[pmid_20231474-6] Mutsafi, Y; Zauberman, N; Sabanay, I; Minsky, A (30 Mar 2010). "Vaccinia-like cytoplasmic replication of the giant Mimivirus". Proceedings of the National Academy of Sciences USA 107 (13): 5978–82. doi:10.1073/pnas.0912737107. PMC 2851855. PMID 20231474. .

[Virology_Blog-7] Racaniello, Vincent (4 March 2014). "Pithovirus: Bigger than Pandoravirus with a smaller genome". Virology Blog. Retrieved 4 March 2014.

[Vaccinia_RNA_pol_35kd_ENTREZ-8] National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. "DNA-dependent RNA polymerase rpo35 (Vaccinia virus)". National Center for Biotechnology Information (NCBI), NIH, Bethesda, MD, USA.

[Bahar-9] Bahar, MW; Graham, SC; Stuart, DI; Grimes, JM (2011). "Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13". Structure 19 (7): 1011–1020. doi:10.1016/j.str.2011.03.023. PMC 3136756. PMID 21742267.

[Prangishvili2004-10] Prangishvili, D; Garrett, RA (2004). "Exceptionally diverse morphotypes and genomes of crenarchaeal hyperthermophilic viruses". Biochem Soc Trans 32 (2): 204–208. doi:10.1042/bst0320204.

[Babkin2006-11] Babkin IV, Shchelkunov SN (2006) The time scale in poxvirus evolution. Mol Biol (Mosk) 40(1):20-24

[Babkin2011-12] Babkin, IV; Babkina, IN (2011). "Molecular dating in the evolution of vertebrate poxviruses". Intervirology 54 (5): 253–260. doi:10.1159/000320964. PMID 21228539.

[Hughes2010-13] Hughes, AL; Irausquin, S; Friedman, R (2010). "The evolutionary biology of poxviruses". Infect Genet Evol 10 (1): 50–59. doi:10.1016/j.meegid.2009.10.001. PMC 2818276. PMID 19833230.

[Gjessing2015-14] Gjessing MC, Yutin N, Tengs T, Senkevich T, Koonin E, Rønning HP, Alarcon M, Ylving S, Lie KI, Saure B, Tran L, Moss B, Dale OB (2015) Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae. J Virol 89(18):9348-9867. doi: 10.1128/JVI.01174-15

[Esposito2006-15] Esposito, JJ; Sammons, SA; Frace, AM; Osborne, JD; Olsen-Rasmussen, M; Zhang, M; Govil, D; Damon, IK; et al. (Aug 2006). "Genome sequence diversity and clues to the evolution of variola (smallpox) virus". Science 313 (5788): 807–812. doi:10.1126/science.1125134. PMID 16873609.

[Li2007-16] Li, Y; Carroll, DS; Gardner, SN; Walsh, MC; Vitalis, EA; Damon, IK (2007). "On the origin of smallpox: correlating variola phylogenics with historical smallpox records". Proc Natl Acad Sci USA 104 (40): 15787–15792. doi:10.1073/pnas.0609268104. PMC 2000395. PMID 17901212.

[Afonso2012-17] Afonso PP, Silva PM, Schnellrath LC, Jesus DM, Hu J, Yang Y, Renne R, Attias M, Condit RC, Moussatché N, Damaso CR (2012) Biological characterization and next-generation genome sequencing of the unclassified Cotia virus SPAn232 (Poxviridae). J Virol

[Roychoudhury2011-18] Roychoudhury, S; Pan, A; Mukherjee, D (2011). "Genus specific evolution of codon usage and nucleotide compositional traits of poxviruses". Virus Genes 42 (2): 189–199. doi:10.1007/s11262-010-0568-2.

[Gubser2004-19] Gubser, C; Hué, S; Kellam, P; Smith, GL (2004). "Poxvirus genomes: a phylogenetic analysis". J Gen Virol 85 (1): 105–117. doi:10.1099/vir.0.19565-0. PMID 14718625.

[Hopkins_2002-20] Hopkins, Donald R. (2002) [1983]. The greatest killer: smallpox in history, with a new introduction. University of Chicago Press. p. 15. By special permission of the late President Anwar el Sadat, I was allowed to examine the front upper half of Ramses V's unwrapped mummy in the Cairo Museum in 1979. …Inspection of the mummy revealed a rash of elevated "pustules," each about two to four millimeters in diameter, …(An attempt to prove that this rash was caused by smallpox by electron-microscopic examination of tiny pieeces of tissue that had fallen on the shroud was unsuccessful. I was not permitted to excise one of the postules.) …The appearance of the larger postules and the apparent distribution of the rash are similar to smallpox rashes I have seen in more recent victims

[21] Date of Ramses V's death derived from the Encyclopedia of Ancient Egypt, Margaret Bunson (New York: Facts On File, 2002) ISBN 0816045631 p.337.

[22] Henderson, D. A.; Inglesby, Thomas V.; Bartlett, John G.; Ascher, Michael S.; Eitzen, Edward; Jahrling, Peter B.; Hauer, Jerome; Layton, Marcelle; McDade, Joseph; Osterholm, Michael T.; O'Toole, Tara; Parker, Gerald; Perl, Trish; Russell, Philip K.; Tonat, Kevin; For The Working Group On Civilian Biodefense (1999). "Smallpox as a Biological Weapon: Medical and Public Health Management". JAMA: the Journal of the American Medical Association 281 (22): 2127–37. doi:10.1001/jama.281.22.2127. PMID 10367824.

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poxvirus