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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/09 23:13:36」(JST)
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| Leporipoxvirus |
| Virus classification |
| Group: |
Group I (dsDNA) |
| Family: |
Poxviridae |
| Subfamily: |
Chordopoxvirinae |
| Genus: |
Leporipoxvirus |
| Type Species |
|
|
Leporipoxvirus is a genus of viruses, in the family Poxviridae, in the subfamily Chordopoxvirinae. Lagomorph and squirrels serve as natural hosts. There are currently four species in this genus including the type species Myxoma virus. Diseases associated with this genus include: myxomatosis.[1][2]
Contents
- 1 Taxonomy
- 2 Structure
- 3 Life Cycle
- 4 References
- 5 External Links
Taxonomy
Group: dsDNA
Order: Unassigned
-
Family: Poxviridae
-
Sub-Family: Chordopoxvirinae
-
Genus: Leporipoxvirus
- Hare fibroma virus
- Myxoma virus
- Rabbit fibroma virus
- Squirrel fibroma virus
[2]
Structure
Viruses in Leporipoxvirus are enveloped, with brick-shaped geometries. Genomes are linear, around 160kb in length.[1]
| Genus |
Structure |
Symmetry |
Capsid |
Genomic Arrangement |
Genomic Segmentation |
| Leporipoxvirus |
Brick-shaped |
|
Enveloped |
Linear |
Monopartite |
Life Cycle
Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell. Fusion with the plasma membrane to release the core into the host cytoplasm. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV). IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV)host receptors, which mediates endocytosis. Replication follows the DNA strand displacement model. Dna templated transcription is the method of transcription. The virus exits the host cell by existing in occlusion bodies after cell death and remaining infectious until finding another host. Lagomorph and squirrels serve as the natural host. Transmission routes are fomite, mechanical, and contact.[1]
| Genus |
Host Details |
Tissue Tropism |
Entry Details |
Release Details |
Replication Site |
Assembly Site |
Transmission |
| Leporipoxvirus |
Lagomorph; squirrels |
None |
Glycosaminoglycans |
Lysis; budding |
Cytoplasm |
Cytoplasm |
Arthropods; contact |
References
- ^ a b c "Viral Zone". ExPASy. Retrieved 15 June 2015.
- ^ a b ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.
External Links
- Viralzone: Leporipoxvirus
- ICTV
English Journal
- Molecular species identification, host preference and detection of myxoma virus in the Anopheles maculipennis complex (Diptera: Culicidae) in southern England, UK.
- Brugman VA1,2,3, Hernández-Triana LM3, Prosser SW4, Weland C5, Westcott DG3, Fooks AR3,6, Johnson N7.
- Parasites & vectors.Parasit Vectors.2015 Aug 15;8:421. doi: 10.1186/s13071-015-1034-8.
- BACKGROUND: Determining the host feeding patterns of mosquitoes by identifying the origin of their blood-meals is an important part of understanding the role of vector species in current and future disease transmission cycles. Collecting large numbers of blood-fed mosquitoes from the field is diffic
- PMID 26271277
- Bertagnoli S, Marchandeau S.
- Revue scientifique et technique (International Office of Epizootics).Rev Sci Tech.2015 Aug;34(2):549-56, 539-47.
- Myxomatosis, a major disease of European rabbits (Oryctolagus cuniculus), is enzootic on several continents. The disease is infectious, virulent and contagious. The pathogen is a virus of the family Poxviridae, genus Leporipoxvirus. In its classic form the disease is often fatal, characterised by se
- PMID 26601455
- Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells.
- Villa NY1, Wasserfall CH2, Meacham AM1, Wise E1, Chan W3, Wingard JR1, McFadden G3, Cogle CR1.
- Blood.Blood.2015 Jun 11;125(24):3778-88. doi: 10.1182/blood-2014-07-587329. Epub 2015 Apr 22.
- Allogeneic hematopoietic cell transplant (allo-HCT) can be curative for certain hematologic malignancies, but the risk of graft-versus-host disease (GVHD) is a major limitation for wider application. Ideally, strategies to improve allo-HCT would involve suppression of T lymphocytes that drive GVHD w
- PMID 25904246
Related Links
- "Leporipoxvirus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are ... A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE ...
- A knowledge resource to understand virus diversity ... VIRION Enveloped, brick-shaped 300×250x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the ...
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