WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA

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1. 上皮性卵巣癌、卵管癌、または腹膜癌の再発に対する薬物療法：プラチナ製剤感受性癌 medical treatment for relapsed epithelial ovarian fallopian tubal or peritoneal cancer platinum sensitive disease
2. ER／PR陰性、HER2陰性（トリプルネガティブ）乳癌の疫学、危険因子および臨床的アプローチ epidemiology risk factors and the clinical approach to er pr negative her2 negative triple negative breast cancer
3. 最新の診療アップデート practice changing updates
4. 成人における抗癌剤の投与 dosing of anticancer agents in adults
5. 遺伝性およびまたは家族性乳癌・卵巣癌患者のマネージメント management of patients with hereditary and or familial breast and ovarian cancer

Primordial dwarfism gene maintains lin28 expression to safeguard embryonic stem cells from premature differentiation.

Dai Q1, Luan G1, Deng L1, Lei T1, Kang H1, Song X1, Zhang Y1, Xiao ZX1, Li Q2.
Cell reports.Cell Rep.2014 May 8;7(3):735-46. doi: 10.1016/j.celrep.2014.03.053. Epub 2014 Apr 24.
Primordial dwarfism (PD) is characterized by global growth failure, both during embryogenesis and postnatally. Loss-of-function germline mutations in La ribonucleoprotein domain family, member 7 (LAPR7) have recently been linked to PD. Paradoxically, LARP7 deficiency was previously assumed to be a
PMID 24768001

Genome-wide RNA-binding analysis of the trypanosome U1 snRNP proteins U1C and U1-70K reveals cis/trans-spliceosomal network.

Preußer C1, Rossbach O, Hung LH, Li D, Bindereif A.
Nucleic acids research.Nucleic Acids Res.2014 Apr 19. [Epub ahead of print]
Trans-splicing in trypanosomes adds a 39-nucleotide mini-exon from the spliced leader (SL) RNA to the 5' end of each protein-coding sequence. On the other hand, cis-splicing of the few intron-containing genes requires the U1 small nuclear ribonucleoprotein (snRNP) particle. To search for potential n
PMID 24748659

Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks.

Martin NT1, Nakamura K2, Paila U3, Woo J2, Brown C2, Wright JA4, Teraoka SN4, Haghayegh S2, McCurdy D5, Schneider M6, Hu H2, Quinlan AR3, Gatti RA7, Concannon P8.
Cell death & disease.Cell Death Dis.2014 Mar 20;5:e1130. doi: 10.1038/cddis.2014.99.
The study of rare human syndromes characterized by radiosensitivity has been instrumental in identifying novel proteins and pathways involved in DNA damage responses to ionizing radiation. In the present study, a mutation in mitochondrial poly-A-polymerase (MTPAP), not previously recognized for its
PMID 24651433

Kinetic analysis of reverse transcriptase activity of bacterial family A DNA polymerases.

Yasukawa Kiyoshi,Konishi Atsushi,Shinomura Mayu,Nagaoka Eriko,Fujiwara Shinsuke
Biochemical and biophysical research communications 427(3), 654-658, 2012-10-26
… In this study, comparative kinetic analysis was performed for the reverse transcriptase activities of the wild-type enzyme of family A DNA polymerase (M1pol(WT)) from Thermus thermophilus M1 and the variant enzyme of family A DNA polymerase (K4pol(L329A)), in which the mutation of Leu329→Ala is undertaken, from Thermotoga petrophila K4. …
NAID 120004945040

Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly(ADP-ribose) polymerase

KU Cheol Ryong,LEE Hyeon Jeong,KIM Suk Kyoung,LEE Eun Young,LEE Mi-Kyung,LEE Eun Jig
Endocrine journal 59(2), 103-109, 2012-02-01
NAID 10030393106

Protein array profiling of mouse serum, six months post whole body radiation with ^<56>Fe

CHATTERJEE Anuran,DIORDIEVA Inna,YUMOTO Kenji,GLOBUS Ruth K.,BHATTACHARYA Sharmila
Journal of toxicological sciences 37(1), 215-217, 2012-02-01
… Of the 25 proteins found to be down-regulated, Poly ADP Ribose Polymerase (PARP) was 13% lower in the 0.5Gy mice and among the up-regulated proteins, beta-Tubulin was found to be 10% higher in the 0.5Gy group compared to the sham-irradiated 0Gy controls. …
NAID 10030037906