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1. 骨髄造血の制御 regulation of myelopoiesis
2. サラセミア症候群の分子病理 molecular pathology of the thalassemic syndromes
3. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus
4. 胎児および新生児における免疫細胞の発達 the development of immune cells in the fetus and neonate
5. 遺伝学およびゲノミクスのためのツール：遺伝子発現プロファイリング tools for genetics and genomics gene expression profiling

Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells.

Liu X, Li X, Zhou L, Li S, Sun J, Wang Z, Gao Y, Jiang Y, Lu H, Wang Q, Dai J.SourceSouthern Medical University, Guangzhou 510515, China; The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Feb 1;102:420-7. doi: 10.1016/j.colsurfb.2012.06.037. Epub 2012 Aug 14.
To develop an optimized simvastatin (SV) delivery device for bone regeneration, SV-loaded poly(ethylene glycol)-poly(ɛ-caprolactone) (PECL) micelles were constructed. The micelles had an average size of 80nm. The in vitro release behavior of SV from the micelles showed prolonged release compared to
PMID 23006576

Array-based transcriptional analysis of Clostridium sporogenes UC9000 during germination, cell outgrowth and vegetative life.

Bassi D, Cappa F, Cocconcelli PS.SourceIstituto di Microbiologia, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza/Via Milano 24, 26100 Cremona, Italy. daniela.bassi@unicatt.it
Food microbiology.Food Microbiol.2013 Feb;33(1):11-23. doi: 10.1016/j.fm.2012.08.004. Epub 2012 Aug 27.
The members of the genus Clostridium, including the spore-forming anaerobic bacteria, have a complex and strictly regulated life cycle, but very little is known about the genetic pathways involved in the different stages of their life cycle. Clostridium sporogenes, a Gram-positive bacterium usually
PMID 23122496

Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.

Luo C, Li B, Liu L, Yin HP, Wang M, Liu JL.SourceSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, China; Fraser Laboratories for Diabetes Research, Department of Medicine, McGill University Health Centre, Montreal, Canada.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2013 Jan 30;365(2):187-96. doi: 10.1016/j.mce.2012.10.018. Epub 2012 Nov 9.
Reg family proteins are expressed in the pancreas and involved in pancreatitis and islet β-cell growth. In order to explore transcriptional control, we transfected luciferase reporter genes driven by Reg promoters into acinar AR42J and islet MIN6 cells. Dexamethasone (DEX) significantly increased t
PMID 23147030

Pop2 phosphorylation at S39 contributes to the glucose repression of stress response genes, HSP12 and HSP26

須田恭之,Pham Thi Kim Lien,Nguyen Thi Minh Viet,Tomoaki Mizuno,Yasuyuki SUDA,Kenji Irie
PLOS ONE 14(4), e0215064, 2019-04
… Pop2 regulates gene expression post-transcriptionally by shortening the poly(A) tail of mRNA. … We previously reported that Pop2 takes a part in the cell wall integrity pathway by regulating LRG1 mRNA; …
NAID 120006714131

Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes

Toru Suzuki,Chisato Kikuguchi,Saori Nishijima,Takeshi Nagashima,Akinori Takahashi,Mariko Okada,Tadashi Yamamoto
Development 146(4), dev168146, 2019-02-15
… Highly expressed mRNAs possess elongated poly(A) tails and are stabilized in Cnot3(-/-) livers, concomitant with an increase of the proteins they encode. … We detect efficient suppression of Cnot3 protein postnatally, demonstrating the crucial contribution of mRNA decay to postnatal liver functional maturation. …
NAID 120006652942

西本裕樹,岩本一平,鈴木彩加,上田敬太郎,木村元気,Ito Kazuhiro,木澤靖夫
薬学雑誌 139(6), 955-961, 2019
… In this study, we determined the effects of neutralization of tumor necrosis factor-α (TNF-α) on corticosteroid insensitivity in mice models of airway inflammation induced by poly(I:C) and tobacco smoke (TS) exposure. … Mice (male A/J strain, 5 weeks old) were exposed to TS for 10 d, or TS for 11 d and poly(I:C) for 3 d. …
NAID 130007657080