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- 1. 心不全患者におけるスタチン療法statin therapy in patients with heart failure [show details]
…is a theoretical concern that lipid lowering with statins may have an adverse effect. Statins have a variety of lipid-independent (pleiotropic) effects that could contribute to improved outcomes in patients …
- 2. 冠動脈疾患患者における脂質低下薬の利益の機序mechanisms of benefit of lipid lowering drugs in patients with coronary heart disease [show details]
… are differences among the statins in their effects on smooth muscle cell apoptosis and collagen biosynthesis . The clinical relevance of the differential tissue effects of statins is uncertain; a comparison …
- 3. スタチン:作用、副作用、および投与statins actions side effects and administration [show details]
… . Statin therapy alters high-density lipoprotein (HDL) cholesterol levels, typically raising them, but these effects vary by statin and by dose of statin and do not correlate with the effects on LDL …
- 4. 筋系に生じるスタチン系薬剤の副作用statin muscle related adverse events [show details]
… for hepatic uptake of statins. Loss of function variant rs4149056 is associated with higher plasma levels of statins, in particular simvastatin and to a lesser extent atorvastatin, leading to greater systemic …
- 5. 心血管疾患の二次予防としての低比重リポタンパク(LDL-C)の管理management of low density lipoprotein cholesterol ldl c in the secondary prevention of cardiovascular disease [show details]
… alone. Some experts initiate statin therapy in these individuals with a moderate- rather than high-intensity statin based on a concern for a greater likelihood of side effects . Age-related reduction in …
English Journal
- Cardiac Regeneration by Statin-Polymer Nanoparticle-Loaded Adipose-Derived Stem Cell Therapy in Myocardial Infarction.
- Yokoyama R, Ii M, Masuda M, Tabata Y, Hoshiga M, Ishizaka N, Asahi M.
- Stem cells translational medicine. 2019 Jun;().
- Clinical trials with autologous adipose-derived stem cell (AdSC) therapy for ischemic heart diseases (IHDs) are ongoing. However, little is known about combinational therapeutic effect of AdSCs and statin poly(lactic-co-glycolic) acid (PLGA) nanoparticles on the ischemic myocardium. We have investig
- PMID 31157513
- Effect of pioglitazone in acute ischemic stroke patients with diabetes mellitus: a nested case-control study.
- Woo MH, Lee HS, Kim J.
- Cardiovascular diabetology. 2019 May;18(1)67.
- Pioglitazone is an oral antidiabetic drug with multiple pleiotropic actions. Recent clinical trials have demonstrated that treatment with pioglitazone reduces cardiovascular risk in patients who have had an ischemic stroke. We examined the secondary preventive effects of pioglitazone in acute ischem
- PMID 31151454
- A possible association between statin use and improved Clostridioides difficile infection mortality in veterans.
- Argamany JR, Lee GC, Duhon BD, Zeidan AR, Young EH, Reveles KR.
- PloS one. 2019 ;14(5)e0217423.
- Clostridioides difficile infection (CDI) is the most common cause of nosocomial diarrhea and places a significant burden on patients and the health care system. Statins could lead to improvements in CDI clinical response due their pleiotropic effects, including immunomodulatory and lipid-lowering ef
- PMID 31136602
Japanese Journal
- Do antilipidemic agents reduce blood pressure?
- Oyama Jun-ichi,Uchida Fumi,Node Koichi
- Vascular Failure 2(1), 6-10, 2018
- … <p>Currently, the prevalence of hypertension (HT), diabetes mellitus (DM), and hyperlipidemia (HL) is high, and these diseases are important risk factors for cardiovascular disease (CVD). … Furthermore, patients with CVD often have more than one of these diseases. …
- NAID 130007399357
- Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice
- Mitsuhashi Takeshi,Uemoto Ryoko,Ishikawa Kazue,Yoshida Sumiko,Ikeda Yasumasa,Yagi Shusuke,Matsumoto Toshio,Akaike Masashi,Aihara Ken-ichi
- Journal of
- … Statins have a protective impact against cardiovascular diseases through not only lipid-lowering effects but also pleiotropic effects, including activation of the endothelial nitric oxide synthase (eNOS) system. … We aimed to clarify the protective effects of a statin against atherogenesis and ischemia in <i>eNOS</i><sup>-/-</sup> …
- NAID 130006301202
- Simvastatin induces the apoptosis of normal vascular smooth musclethrough the disruption of actin integrity via the impairment of RhoA/Rac-1 activity
- KANG Seojin,BIAN Yiying,KIM Keunyoung,CHUNG Jin-Ho
- 日本毒性学会学術年会 44.1(0), P-166, 2017
- … Statins, lipid-lowering agents for the prevention of atherosclerosis and fatal coronary heart diseases, have pleiotropic modalities on the function and physiology of vascular smooth muscle that include anti-contractile and pro-apoptotic effects. … These effects were suggested to stem from the inhibition of small GTPase Rho A, but they are largely regarded as distinct and unrelated. …
- NAID 130006581992
Related Links
- Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefits observed with statins appear ...
- Statins or 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors not only prevents the synthesis of cholesterol biosynthesis but also inhibits the synthesis of essential isoprenoid intermediates such as ...
- Pleiotropic Effects of Statins The word pleiotropic originally referred to a gene that influenced or affected more than one trait in an organism, several phenotypic expressions. The word has been borrowed to the world of pharmacology ...
★リンクテーブル★
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- (変化などを)もたらす。(目的・計画など)果たす、遂げる。実施/施行する
- 関
- act, action, affect, efficacy, impact, impinge, indication, influence, potency, effected
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- pleio + tropic
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HMG-CoA還元酵素阻害薬
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HMG-CoA還元酵素阻害薬