platelet antagonist

抗血小板薬

WordNet

1. a drug that neutralizes or counteracts the effects of another drug
2. a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
3. tiny bits of protoplasm found in vertebrate blood; essential for blood clotting (同)blood_platelet, thrombocyte

PrepTutorEJDIC

1. 対立する人,敵対者,競争相手(opponent)

UpToDate Contents

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• 1. 止血の概要 overview of hemostasis
• 2. 血小板機能検査 platelet function testing
• 3. 血小板生物学 platelet biology
• 4. 血小板輸血療法の臨床上および検査上の特徴 clinical and laboratory aspects of platelet transfusion therapy
• 5. 原因不明の血小板減少症を有する成人に対するアプローチ approach to the adult with unexplained thrombocytopenia

English Journal

• Effects of ticagrelor on the sodium/calcium exchanger 1 (NCX1) in cardiac derived H9c2 cells.

• Lariccia V, Macrì ML, Matteucci A, Maiolino M, Amoroso S, Magi S.
• European journal of pharmacology. 2019 May;850()158-166.
• Ticagrelor is a direct acting and reversibly binding P2Y antagonist approved for the prevention of thromboembolic events. Clinical effects of ticagrelor cannot be simply accounted for by pure platelet inhibition, and off-target mechanisms can potentially play a role. In particular, recent evidence s
• PMID 30721704

• The therapeutic potential of ginkgolide K in experimental autoimmune encephalomyelitis via peripheral immunomodulation.

• Yu WB, Wang Q, Chen S, Cao L, Tang J, Ma CG, Xiao W, Xiao BG.
• International immunopharmacology. 2019 May;70()284-294.
• Multiple sclerosis is a T cell-mediated inflammatory, demyelinating disease of the central nervous system, accompanied by neuronal degeneration. Based on the anti-inflammatory effects of Ginkgolide K (GK), a platelet activating factor antagonist, we explored the possible application of GK in the tre
• PMID 30851709

• Platelet Surface CD62p and Serum Vitamin D Levels are Associated with Clopidogrel Resistance in Chinese Patients with Ischemic Stroke.

• Lu BC, Shi XJ, Liang L, Dong N, Liu ZZ.
• Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2019 May;28(5)1323-1328.
• To explore the association of platelet activation markers, vitamin D, and antiplatelet drugs resistance in ischemic stroke patients. A total of 230 patients with ischemic stroke were enrolled in this study. Platelet aggregation, platelet activation marker (CD62p), and vitamin D were measured after 7
• PMID 30795966

Japanese Journal

• デクスメデトミジンはα2アドレナリン受容体を介してヒト血小板由来マイクロパーティクル産生を増加させる

• 日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine 25(6), 457-459, 2018-11-01
• NAID 120006545212

• AVR 術後に発症した遅延発症型ヘパリン起因性血小板減少症（HIT）の1例

• 日本心臓血管外科学会雑誌 47(3), 113-117, 2018
• NAID 130007382770

• Survival of HeartMate Ⅱ Patients Despite Cessation of Anticoagulation : Outcomes and Hemostatic Analysis

• 日本循環器學誌 82(5), 1309-1318, 2018
• NAID 130006725965

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★リンクテーブル★

リンク元	「抗血小板薬」「platelet aggregation inhibitor」「platelet inhibitor」

「抗血小板薬」

　　[★]

英

antiplatelet agent、antiplatelet drug、platelet antagonist

関

血小板凝集阻害薬、血小板凝集阻害剤、血小板凝集抑制薬、血小板抑制薬、抗血小板剤

関

血小板凝集抑制薬

シクロオキシゲナーゼ阻害薬

• アスピリン：

ホスホジエステラーゼ阻害薬

• ジピリダモール
• シロスタゾール(プレタール)：セロトニン放出を抑制、トロンボキサンA2による血小板凝集を抑制、cAMPホスホジエステラーゼ活性を阻害(PDE3)

ADP受容体阻害薬

• チクロピジン(パナルジン)：(副作用)肝障害、白血球減少、血小板減少
• クロピドグレル(プラビックス)：チクロピジンに比べて副作用の発現減少

ガイドライン

• 循環器疾患における抗凝固・抗血小板療法に関するガイドライン（2009年改訂版）

http://www.j-circ.or.jp/guideline/pdf/JCS2009_hori_h.pdf

「platelet aggregation inhibitor」

　　[★]

• 血小板凝集抑制薬、血小板凝集抑制剤、血小板凝集阻害薬、血小板凝集阻害剤

関

antiplatelet agent、antiplatelet drug、platelet antagonist、platelet inhibitor

「platelet inhibitor」

　　[★]

• 血小板凝集抑制薬、血小板抑制薬

関

antiplatelet agent、antiplatelet drug、platelet aggregation inhibitor、platelet antagonist