関: plasma cell tumor

WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
(physical chemistry) a fourth state of matter distinct from solid or liquid or gas and present in stars and fusion reactors; a gas becomes a plasma when it is heated until the atoms lose all their electrons, leaving a highly electrified collection of nuclei and free electrons; "particles in space exist in the form of a plasma"
a green slightly translucent variety of chalcedony used as a gemstone
the colorless watery fluid of the blood and lymph that contains no cells, but in which the blood cells (erythrocytes, leukocytes, and thrombocytes) are suspended (同)plasm, blood_plasma

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
(また『blood plasma』)血漿,リンパ漿 / 原形質
(体内にできる)新生物;腫瘍(しゅよう)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/12 19:25:09」(JST)

wiki en

Plasma cell dyscrasias are cancers of the plasma cells. Plasma cell dyscrasias are produced as a result of malignant proliferation of a monoclonal population of plasma cells that may or may not secrete detectable levels of a monoclonal immunoglobulin or paraprotein commonly referred to as M protein. Although the most common plasma cell dyscrasia is monoclonal gammopathy of undetermined significance (MGUS); closely related disorders include multiple myeloma, solitary plasmacytoma of bone, extramedullary plasmacytoma, Waldenström's macroglobulinemia (WM), primary amyloidosis, light chain deposition disease and heavy-chain disease. The spectrum of MGUS, solitary plasmacytoma of bone, and asymptomatic and symptomatic multiple myeloma may actually represent a natural progression of the same disease.^[1]

See paraproteinemia

Classification[edit]

Cryoglobulinemia
Heavy chain disease
Monoclonal gammopathy of undetermined significance
Multiple myeloma
Plasmacytoma
Plasma cell leukemia
POEMS syndrome
Primary amyloidosis (Immunoglobulin light chain amyloidosis)
Waldenström's macroglobulinemia

References[edit]

^ http://www.accessmedicine.com/content.aspx?aid=2794254 DEAD URL DEC 2012

External links[edit]

Multiple Myeloma and Other Plasma Cell Dyscrasias. 2011

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UpToDate Contents

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1. 多発性骨髄腫の臨床的特徴、検査所見、および診断 clinical features laboratory manifestations and diagnosis of multiple myeloma
2. 形質細胞白血病 plasma cell leukemia
3. 造血腫瘍の分類 classification of the hematopoietic neoplasms
4. 孤立性髄外性形質細胞腫の診断およびマネージメント diagnosis and management of solitary extramedullary plasmacytoma
5. 肺の炎症性筋線維芽細胞性腫瘍（形質細胞肉芽腫） inflammatory myofibroblastic tumor plasma cell granuloma of the lung

English Journal

TAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenström's macroglobulinemia.

Ghobrial IM1, Siegel DS2, Vij R3, Berdeja JG4, Richardson PG1, Neuwirth R5, Patel CG6, Zohren F7, Wolf JL8.
American journal of hematology.Am J Hematol.2016 Jun;91(4):400-5. doi: 10.1002/ajh.24300.
The PI3K/AKT/mTOR signaling pathways are frequently dysregulated in multiple human cancers, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and Waldenström's macroglobulinemia (WM). This was the first clinical study to evaluate the safety, tolerability, maximal-tolerated dose (MTD), do
PMID 26800393

Bone marrow infiltration by multiple myeloma causes anemia by reversible disruption of erythropoiesis.

Bouchnita A1, Eymard N1, Moyo TK2, Koury MJ2, Volpert V1,3.
American journal of hematology.Am J Hematol.2016 Jun;91(4):371-8. doi: 10.1002/ajh.24291. Epub 2016 Feb 9.
Multiple myeloma (MM) infiltrates bone marrow and causes anemia by disrupting erythropoiesis, but the effects of marrow infiltration on anemia are difficult to quantify. Marrow biopsies of newly diagnosed MM patients were analyzed before and after four 28-day cycles of nonerythrotoxic remission indu
PMID 26749142

Low immunoglobulin A levels detected via the tissue transglutaminase assay can reveal previously undetected monoclonal proteins.

Wallage M1, Dutton D2, Lock RJ3.
Annals of clinical biochemistry.Ann Clin Biochem.2016 May;53(Pt 3):409-11. doi: 10.1177/0004563215625692. Epub 2015 Dec 17.
Increased awareness of coeliac disease and the 2009 NICE guidance has led to an increase in patients being screened for Immunoglobulin A deficiency. We have shown previously that this provides an opportunity for the early identification of other underlying primary immunodeficiency, e.g. common varia
PMID 26684021