phosphatidylethanolamine binding protein

ホスファチジルエタノールアミン結合タンパク質

関

PEBP

WordNet

1. executed with proper legal authority; "a binding contract"
2. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
3. strip sewn over or along an edge for reinforcement or decoration
4. the capacity to attract and hold something
5. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

1. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/17 14:58:50」(JST)

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[Wiki en表示]

This article is about various membranes in living things. For the membranes surrounding cells, see cell membrane.

Cross-section view of the structures that can be formed by phospholipids in aqueous

A biological membrane or biomembrane is an enclosing or separating membrane that acts as a selectively permeable barrier within living things. Biological membranes, in the form of cell membranes, often consist of a phospholipid bilayer with embedded, integral and peripheral proteins used in communication and transportation of chemicals and ions. The cellular membranes should not be confused with isolating tissues formed by layers of cells, such as mucous membranes and basement membranes.

Function

The phospholipid bilayer contains a charged hydrophilic head, which interacts with polar water. It also contains a hydrophobic tail, which meets with the hydrophobic tail of the complementary layer. This maintains the fluidity of the cell.

Membranes in cells typically define enclosed spaces or compartments in which cells may maintain a chemical or biochemical environment that differs from the outside. For example, the membrane around peroxisomes shields the rest of the cell from peroxides, chemicals that can be toxic to the cell, and the cell membrane separates a cell from its surrounding medium. Peroxisomes are one form of vacuole found in the cell that contain by-products of chemical reactions within the cell. Most organelles are defined by such membranes, and are called "membrane-bound" organelles.

Probably the most important feature of a biomembrane is that it is a selectively permeable structure. This means that the size, charge, and other chemical properties of the atoms and molecules attempting to cross it will determine whether they succeed in doing so. Selective permeability is essential for effective separation of a cell or organelle from its surroundings. Biological membranes also have certain mechanical or elastic properties that allow them to change shape and move as required.

Particles that are required for cellular function but are unable to diffuse freely across a membrane enter through a membrane transport protein or are taken in by means of endocytosis, where the membrane allows for a vacuole to join onto it and push its contents into the cell. Many types of specialized plasma membranes can separate cell from external environment: apical, basolateral, presynaptic and postsynaptic ones, membranes of flagella, cilia, microvillus, filopodia and lamellipodia, the sarcolemma of muscle cells, as well as specialized myelin and dendritic spine membranes of neurons. Plasma membranes can also form different types of "supramembrane" structures such as caveola, postsynaptic density, podosome, invadopodium, desmosome, hemidesmosome, focal adhesion, and cell junctions. These types of membranes differ in lipid and protein composition.

Distinct types of membranes also create intracellular organelles: endosome; smooth and rough endoplasmic reticulum; sarcoplasmic reticulum; Golgi apparatus; lysosome; mitochondrion (inner and outer membranes); nucleus (inner and outer membranes); peroxisome; vacuole; cytoplasmic granules; cell vesicles (phagosome, autophagosome, clathrin-coated vesicles, COPI-coated and COPII-coated vesicles) and secretory vesicles (including synaptosome, acrosomes, melanosomes, and chromaffin granules). Different types of biological membranes have diverse lipid and protein compositions. The content of membranes defines their physical and biological properties. Some components of membranes play a key role in medicine, such as the efflux pumps that pump drugs out of a cell.

See also

• Basement membrane
• Biofilm
• Bladder (disambiguation)
• Fetal membranes of amnion and chorion
• Membrane lipids
• Membrane protein
• Mucous membrane
• Osmosis
• S-layer
• Serous membrane
• Tympanic membrane

References

General

• von Heijne G, Rees D (August 2008). "Membranes: reading between the lines". Curr. Opin. Struct. Biol. 18 (4): 403–5. doi:10.1016/j.sbi.2008.06.003. PMID 18634876. 

External links

• Membranes at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy
• 2. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
• 3. 鉄のバランス調節 regulation of iron balance
• 4. メチシリン耐性黄色ブドウ球菌の微生物学 microbiology of methicillin resistant staphylococcus aureus
• 5. 妊娠37週未満の前期（陣痛開始前）破水 preterm premature prelabor rupture of membranes

English Journal

• Crystal structure study of GnsA from Escherichia Coli.

• Wei Y1, Zhan L2, Gao Z3, Privé GG4, Dong Y5.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Mar 31. pii: S0006-291X(15)00599-9. doi: 10.1016/j.bbrc.2015.03.133. [Epub ahead of print]
• Escherichia Coli GnsA is a regulator of phosphatidylethanolamine synthesis functioning as a suppressor of both secG null mutation and fabA6 mutations. GnsA is also supposed to be a toxin with the cognate antitoxin YmcE. Here we report the crystal structure of GnsA in 1.8 Å. GnsA forms a hairpin V s
• PMID 25839658

• IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism.

• Albano GD1, Zhao J2, Etling EB3, Park SY4, Hu H3, Trudeau JB3, Profita M5, Wenzel SE3.
• The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2015 Mar 24. pii: S0091-6749(15)00226-2. doi: 10.1016/j.jaci.2015.02.006. [Epub ahead of print]
• BACKGROUND: β2-Adrenergic receptor (β2AR) agonists are critical treatments for asthma. However, receptor desensitization can lead to loss of therapeutic effects. Although desensitization to repeated use of β2-agonists is well studied, type 2 inflammation could also affect β2AR function.OBJECTIVE
• PMID 25819984

• General and specific lipid-protein interactions in Na,K-ATPase.

• Cornelius F1, Habeck M2, Kanai R3, Toyoshima C3, Karlish SJ2.
• Biochimica et biophysica acta.Biochim Biophys Acta.2015 Mar 16. pii: S0005-2736(15)00091-7. doi: 10.1016/j.bbamem.2015.03.012. [Epub ahead of print]
• The molecular activity of Na,K-ATPase and other P2 ATPases like Ca2+-ATPase is influenced by the lipid environment via both general (physical) and specific (chemical) interactions. Whereas the general effects of bilayer structure on membrane protein function are fairly well described and understood,
• PMID 25791351

Japanese Journal

• 静的・動的構造評価による生体脂質複合体形成機構の解明

• 中野 実
• YAKUGAKU ZASSHI 129(9), 1033-1039, 2009
• …   Biomembrane is a place for signal transduction, where protein-membrane interactions are controlled by the membrane environment. … This review describes our recent studies for 1) the production of lipid nanoparticles with nonlamellar liquid crystalline phases, 2) membrane-protein interaction that relates to the biogenesis of high-density lipoproteins, and 3) the characterization of lipid transfer dynamics by small-angle neutron scattering (SANS). …
• NAID 130000136000

• Biochemical Analysis of the Yeast Proteinase Inhibitor (I^C) Homolog I^Ch and Its Comparison with I^C

• FUKADA Hiroaki,MIMA Joji,NAGAYAMA Mitsuru,KATO Michiko,UEDA Mitsuyoshi
• Bioscience, biotechnology, and biochemistry 71(2), 472-480, 2007-02-23
• … Carboxypeptidase Y (CPY) inhibitor (IC) and its homologous protein (ICh) are thought to be members of the phosphatidylethanolamine-binding protein (PEBP) family of Saccharomyces cerevisiae. … ICh is folded as a monomeric β-protein and is devoid of disulfide bonds. …
• NAID 10027511662

Related Links

• Phosphatidylethanolamine binding protein 1 - Wikipedia, the free ...

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene. [edit] Interactions. Phosphatidylethanolamine binding protein 1 has been shown to interact with MAP2K1, C-Raf and MAPK1.

Related Pictures

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★リンクテーブル★

リンク元	「PEBP」「ホスファチジルエタノールアミン結合タンパク質」
関連記事	「binding」「binding protein」「phosphatidylethanolamine」

「PEBP」

　　[★]

• ホスファチジルエタノールアミン結合タンパク質

関

phosphatidylethanolamine binding protein

「ホスファチジルエタノールアミン結合タンパク質」

　　[★]

英

phosphatidylethanolamine binding protein、PEBP

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「binding protein」

　　[★]

• 結合タンパク質、結合タンパク、結合蛋白質、結合蛋白

関

BP、carrier protein、transport protein

「phosphatidylethanolamine」

　　[★] ホスファチジルエタノールアミン