MAPキナーゼp38、p38-MAPキナーゼ、p38マイトジェン活性化プロテインキナーゼ

関: mitogen-activated protein kinase p38、p38 MAP kinase、p38 MAPK、p38 protein kinase

WordNet

aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
make (substances) radioactive
make active or more active; "activate an old file"
make more adsorptive; "activate a metal"
rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
(of e.g. a molecule) made reactive or more reactive (同)excited
(military) set up and placed on active assignment; "a newly activated unit"
(of sewage) treated with aeration and bacteria to aid decomposition
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
an agent that triggers mitosis

PrepTutorEJDIC

…'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/12 06:39:37」(JST)

wiki en

[Wiki en表示]

P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.

p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast Hog1p MAP kinase,^[1] which participates in a signaling cascade controlling cellular responses to cytokines and stress.

Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.

mitogen-activated protein kinase 14
Identifiers
Symbol	MAPK14
Alt. symbols	CSPB1, CSBP1, CSBP2
Entrez	1432
HUGO	6876
OMIM	600289
RefSeq	NM_001315
UniProt	Q16539
Other data
EC number	2.7.11.24
Locus	Chr. 6 p21.3-21.2

MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac and MEF2. p38 also has been shown to phosphorylate post-transcriptional regulating factors like TTP.^[2]

P38 inhibitors

P38 inhibitors are being sought for possible therapeutic effect on autoimmune diseases and inflammatory processes,^[3] e.g. pamapimod.^[4] Some have started clinical trials, e.g. PH-797804 for COPD.^[5] Other p38 inhibitors include BIRB 796, VX-702, SB 239063, SB202190, SCIO 469, and BMS 582949.

References

^ Han J, Lee JD, Bibbs L, Ulevitch RJ (August 1994). "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells". Science 265 (5173): 808–11. doi:10.1126/science.7914033. PMID 7914033.
^ Tudor C, Marchese FP, Hitti E, Aubareda A, Rawlinson L, Gaestel M, Blackshear PJ, Clark AR, Saklatvala J, Dean JL (June 2009). "The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages". FEBS Lett. 583 (12): 1933–8. doi:10.1016/j.febslet.2009.04.039. PMID 19416727.
^ Goldstein DM, Gabriel T (2005). "Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development". Current topics in medicinal chemistry 5 (10): 1017–29. doi:10.2174/1568026054985939. PMID 16178744.
^ Hill RJ, Dabbagh K, Phippard D, Li C, Suttmann RT, Welch M, Papp E, Song KW, Chang KC, Leaffer D, Kim YN, Roberts RT, Zabka TS, Aud D, Dal Porto J, Manning AM, Peng SL, Goldstein DM, Wong BR (December 2008). "Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". J. Pharmacol. Exp. Ther. 327 (3): 610–9. doi:10.1124/jpet.108.139006. PMID 18776065.
^ "Novel p38 Inhibitor Shows Promise as Anti-Inflammatory Treatment for Patients With COPD". 2010.

External links

p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
P38mapkPathway
p38 Signaling Pathway
MAP Kinase Resource
p38 MAPK Pathway

This enzyme-related article is a stub. You can help Wikipedia by expanding it.

Molecular and Cellular Biology portal

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. Reperfusion injury of the heart
2. Mechanisms and clinical implications of glucocorticoid resistance in asthma
3. 慢性関節リウマチにおける滑膜異常 synovial pathology in rheumatoid arthritis
4. 非喫煙者における肺癌 lung cancer in never smokers
5. Myocardial ischemic conditioning: Pathogenesis

English Journal

Effect of Electroacupuncture on Activation of p38MAPK in Spinal Dorsal Horn in Rats with Complete Freund's Adjuvant-Induced Inflammatory Pain.

Liang Y, Fang JQ, Du JY, Fang JF.SourceThe Third Clinical Medical College, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou City, Zhejiang Province 310053, China.
Evidence-based complementary and alternative medicine : eCAM.Evid Based Complement Alternat Med.2012;2012:568273. Epub 2011 Aug 8.
Activation of mitogen-activated protein kinases (MAPKs), especially p38 MAPK, plays an important role in the development of central sensitization related to persistent inflammatory pain. Electroacupuncture (EA) is well known to relieve persistent inflammatory pain. However, little is known about rel
PMID 21860653

Attenuation of pro-inflammatory mediators in LPS-stimulated BV2 microglia by chitooligosaccharides via the MAPK signaling pathway.

Pangestuti R, Bak SS, Kim SK.SourceMarine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, South Korea.
International journal of biological macromolecules.Int J Biol Macromol.2011 Nov 1;49(4):599-606. Epub 2011 Jun 17.
Chitooligosaccharides (COS), depolymerized products of chitosan, has received considerable attention as bioactive material due to their biocompatible, biodegradable, non-toxic and non-allergenic natures. In this study, COS of four different molecular weight ranges (<1, 1-3, 3-5 and 5-10kDa) were
PMID 21704648

Japanese Journal

Involvement of MAPKs in ICAM-1 Expression in Glomerular Endothelial Cells in Diabetic Nephropathy

Watanabe Naomi,Shikata Kenichi,Shikata Yasushi,Sarai Kei,Omori Kazuyoshi,Kodera Ryo,Sato Chikage,Wada Jun,Makino Hirofumi
Acta Medica Okayama 65(4), 247-257, 2011-08
… The aim of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in glomerular endothelial cells under diabetic conditions. …
NAID 120003290176

High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells.

Nakamura Shigeki,Yanagihara Katsunori,Araki Nobuko,Yamada Koichi,Morinaga Yoshitomo,Izumikawa Koichi,Seki Masafumi,Kakeya Hiroshi,Yamamoto Yoshihiro,Kamihira Shimeru,Kohno Shigeru
European journal of pharmacology 659(1), 67-71, 2011-05-20
… We demonstrate that high-dose tobramycin decreases MUC5AC gene expression and protein production in NCI-H292 cell stimulated with lipopolysaccharide of P. … MUC5AC protein of NCI-H292 cell stimulated by lipopolysaccharide was analyzed by an enzyme-linked immunosorbent assay and MUC5AC expression at the mRNA level was analyzed by RT-PCR. …
NAID 120003220709

「p38マイトジェン活性化プロテインキナーゼ」

mitogen-activated protein kinase 13
Identifiers
Symbol	MAPK13
Alt. symbols	PRKM13
Entrez	5603
HUGO	6875
OMIM	602899
RefSeq	NM_002754
UniProt	O15264
Other data
EC number	2.7.11.24
Locus	Chr. 6 p21

mitogen-activated protein kinase 12
Identifiers
Symbol	MAPK12
Alt. symbols	SAPK3
Entrez	6300
HUGO	6874
OMIM	602399
RefSeq	NM_002969
UniProt	P53778
Other data
EC number	2.7.11.24
Locus	Chr. 22 q13.3

mitogen-activated protein kinase 11
Identifiers
Symbol	MAPK11
Alt. symbols	PRKM11
Entrez	5600
HUGO	6873
OMIM	602898
RefSeq	NM_002751
UniProt	Q15759
Other data
EC number	2.7.11.24
Locus	Chr. 22 q13.33

　　[★]

英: p38 mitogen-activated protein kinase、p38 MAP kinase、p38 MAPK、mitogen-activated protein kinase p38
関: p38プロテインキナーゼ、MAPキナーゼp38、p38-MAPキナーゼ

「p38 MAPK」

　　[★]

p38マイトジェン活性化プロテインキナーゼ

関: mitogen-activated protein kinase p38、p38 MAP kinase、p38 mitogen-activated protein kinase、p38 protein kinase

「mitogen-activated protein kinase p38」

　　[★]

p38マイトジェン活性化プロテインキナーゼ、MAPキナーゼp38

関: p38 MAP kinase、p38 MAPK、p38 mitogen-activated protein kinase、p38 protein kinase

「p38 MAP kinase」

　　[★]

p38マイトジェン活性化プロテインキナーゼ

関: mitogen-activated protein kinase p38、p38 MAPK、p38 mitogen-activated protein kinase、p38 protein kinase

「MAPキナーゼp38」

　　[★]

英: p38 mitogen-activated protein kinase、mitogen-activated protein kinase p38
関: p38マイトジェン活性化プロテインキナーゼ、p38-MAPキナーゼ

「activated」

　　[★]

adj.

活性化の、活性化型の、賦活化の

関: activate、activated form、activation、turn on

「activate」

　　[★]

v.

活性化する、賦活化する、賦活する

関: activated、activation、turn on

「kinase」

　　[★] キナーゼカイネースリン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同: protein kinases

「p」

　　[★]

ピコ

10の-12乗

関: pico

[pmid7914033-1] Han J, Lee JD, Bibbs L, Ulevitch RJ (August 1994). "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells". Science 265 (5173): 808–11. doi:10.1126/science.7914033. PMID 7914033.

[pmid19416727-2] Tudor C, Marchese FP, Hitti E, Aubareda A, Rawlinson L, Gaestel M, Blackshear PJ, Clark AR, Saklatvala J, Dean JL (June 2009). "The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages". FEBS Lett. 583 (12): 1933–8. doi:10.1016/j.febslet.2009.04.039. PMID 19416727.

[pmid16178744-3] Goldstein DM, Gabriel T (2005). "Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development". Current topics in medicinal chemistry 5 (10): 1017–29. doi:10.2174/1568026054985939. PMID 16178744.

[pmid18776065-4] Hill RJ, Dabbagh K, Phippard D, Li C, Suttmann RT, Welch M, Papp E, Song KW, Chang KC, Leaffer D, Kim YN, Roberts RT, Zabka TS, Aud D, Dal Porto J, Manning AM, Peng SL, Goldstein DM, Wong BR (December 2008). "Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". J. Pharmacol. Exp. Ther. 327 (3): 610–9. doi:10.1124/jpet.108.139006. PMID 18776065.

[5] "Novel p38 Inhibitor Shows Promise as Anti-Inflammatory Treatment for Patients With COPD". 2010.

リンク元	「p38マイトジェン活性化プロテインキナーゼ」「p38 MAPK」「mitogen-activated protein kinase p38」「p38 MAP kinase」「MAPキナーゼp38」
関連記事	「activated」「activate」「kinase」「protein kinase」「p」

匿名

検索

案内

案内

p38 mitogen-activated protein kinase