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composed of or containing bone; "osseous tissue" (同)osteal, bony

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骨の,骨に似た

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/10 07:54:09」(JST)

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In histology, osteoid is the unmineralized, organic portion of the bone matrix that forms prior to the maturation of bone tissue. Osteoblasts begin the process of forming bone tissue by secreting the osteoid as several specific proteins. When the osteoid becomes mineralized, it and the adjacent bone cells have developed into new bone tissue.

Osteoid makes up about fifty percent of bone volume and forty percent of bone weight. It is composed of fibers and ground substance. The predominant fiber-type is Type I collagen and comprises ninety percent of the osteoid. The ground substance is mostly made up of chondroitin sulfate and osteocalcin.

Disorders

When there is insufficient nutrient minerals or osteoblast dysfunction, the osteoid does not mineralize properly, and it accumulates. The resultant disorder is termed rickets in children and osteomalacia in adults.

In some cases, secondary hyperperathyroidism can cause disturbance in mineralisation of calcium and phosphate.

Another very rare condition is a disturbance in primitive transformed cells of mesenchymal origin which exhibit osteoblastic differentiation and produce malignant osteoid. This results in the formation of a malignant primary bone tumor known as osteosarcoma or osteogenic sarcoma. This malignancy most often develops in adolescence during periods of rapid osteoid formation (commonly referred to as growth spurts).^[1]

References

^ Ottaviani Giulia; Jaffe Norman (2009). The epidemiology of osteosarcoma. In: Jaffe N. et al. "Pediatric and Adolescent Osteosarcoma". New York: Springer. doi:10.1007/978-1-4419-0284-9_1. ISBN 978-1-4419-0283-2. PMID 20213383.

Netter, Frank H. (1987), Musculoskeletal system: anatomy, physiology, and metabolic disorders, Summit, New Jersey: Ciba-Geigy Corporation
Jaffe, N.; et al. (2009). Pediatric and Adolescent Osteosarcoma. New York: Springer. ISBN 978-1-4419-0283-2.

External links

Histology image: 69_03 at the University of Oklahoma Health Sciences Center - "Bone, femur"
Dr. Susan Ott's website on osteomalacia

UpToDate Contents

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1. 骨肉腫：疫学、病因、臨床症状、診断、および組織学的検査 osteosarcoma epidemiology pathogenesis clinical presentation diagnosis and histology
2. 小児および思春期における良性骨腫瘍：概要 benign bone tumors in children and adolescents an overview
3. 小児における股関節痛の概要 overview of hip pain in childhood
4. 小児および思春期における腰痛：原因の概要 back pain in children and adolescents overview of causes
5. 小児および青年のアスリートにおける脊椎分離症および脊椎すべり症：臨床症状、画像診断、および診断 spondylolysis and spondylolisthesis in child and adolescent athletes clinical presentation imaging and diagnosis

English Journal

Interventional MSK procedures: the hip.

Dodré E1, Lefebvre G1, Cockenpot E1, Chastanet P1, Cotten A1.
The British journal of radiology.Br J Radiol.2016 Jan;89(1057):20150408. doi: 10.1259/bjr.20150408. Epub 2015 Sep 23.
Percutaneous musculoskeletal procedures are widely accepted as low invasive, highly effective, efficient and safe methods in a vast amount of hip pathologies either in diagnostic or in therapeutic management. Hip intra-articular injections are used for the symptomatic treatment of osteoarthritis. Pe
PMID 26317896

Paediatric musculoskeletal interventional radiology.

Natali GL1, Paolantonio G1, Fruhwirth R1, Alvaro G1, Parapatt GK1, Toma' P2, Rollo M1.
The British journal of radiology.Br J Radiol.2016 Jan;89(1057):20150369. doi: 10.1259/bjr.20150369. Epub 2015 Sep 23.
Interventional radiology technique is now well established and widely used in the adult population. Through minimally invasive procedures, it increasingly replaces surgical interventions that involve higher percentages of invasiveness and, consequently, of morbidity and mortality. For these advantag
PMID 26235144

SATB2 expression is sensitive but may not be specific for osteosarcoma compared to other high-grade primary bone sarcomas.

Davis JL1, Horvai AE2.
Histopathology.Histopathology.2015 Dec 8. doi: 10.1111/his.12911. [Epub ahead of print]
AIMS: Diagnosis of osteosarcoma, while important for eligibility in clinical trials and proper therapy, may be challenging when no bone or osteoid matrix is identified on biopsy. Therefore, other adjunct tests have been sought to help confirm the diagnosis. SATB2 has been shown as a reliable marker
PMID 26644288

Japanese Journal

類骨骨腫 (シンポジウム良性腫瘍に対する最新の治療戦略)

篠崎哲也,斎藤健一,柳川天志 [他]
臨床整形外科 49(3), 221-225, 2014-03
NAID 40020004388

Long-term Observation of Osteomalacia Caused by Adefovir-Induced Fanconi's Syndrome

Terasaka Tomohiro,Ueta Eijiro,Ebara Hirotaka,Waseda Koichi,Hanayama Yoshihisa,Takaki Akinobu,Kawabata Tomoko,Sugiyama Hitoshi,Hidan Ko,Otsuka Fumio
Acta Medica Okayama 68(1), 53-56, 2014-02
… In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. …
NAID 120005372647

Primary Ischial Osteosarcoma Occupying the Pelvic Cavity in a Japanese Black Cow

NAGAMINE Eiji,MATSUDA Kazuya,ISHII Chiaki,KOIWA Masateru,TANIYAMA Hiroyuki
Journal of Veterinary Medical Science, 2014
… Histologically, the mass was composed of neoplastic osteoblasts and exhibited osteoid and immature trabecular bone production. …
NAID 130003391278

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