WordNet
- remove the bones from; "bone the turkey before roasting it" (同)debone
- the porous calcified substance from which bones are made (同)osseous_tissue
- consisting of or made up of bone; "a bony substance"; "the bony framework of the body"
- a shade of white the color of bleached bones (同)ivory, pearl, off-white
- rigid connective tissue that makes up the skeleton of vertebrates (同)os
- composed of or containing bone; "osseous tissue" (同)osteal, bony
- a mouth or mouthlike opening
PrepTutorEJDIC
- 〈C〉骨 / 〈U〉骨を作っている物質,骨質 / 《複数形で》骨格;死骸(がい) / 〈魚など〉‘の'骨を取る
- 骨の,骨に似た
UpToDate Contents
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- 1. 爪膝蓋骨症候群 nail patella syndrome
- 2. 成人における膝関節腫瘍のX線評価 radiologic evaluation of knee tumors in adults
- 3. 全人工膝関節置換術 total knee arthroplasty
English Journal
- Spatial patterning of BMP-2 and BMP-7 on biopolymeric films and the guidance of muscle cell fate.
- Almodóvar J1, Guillot R1, Monge C1, Vollaire J2, Selimović S3, Coll JL2, Khademhosseini A4, Picart C5.Author information 1CNRS UMR 5628 (LMGP), MINATEC, 3 parvis Louis Néel, 38016 Grenoble, France; Université de Grenoble Alpes, Grenoble Institute of Technology, 3 parvis Louis Néel, 38016 Grenoble, France.2Institute Albert Bonniot, Grenoble, France.3Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.4Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.5CNRS UMR 5628 (LMGP), MINATEC, 3 parvis Louis Néel, 38016 Grenoble, France; Université de Grenoble Alpes, Grenoble Institute of Technology, 3 parvis Louis Néel, 38016 Grenoble, France. Electronic address: catherine.picart@grenoble-inp.fr.AbstractIn the cellular microenvironment, growth factor gradients are crucial in dictating cell fate. Towards developing materials that capture the native microenvironment we engineered biomimetic films that present gradients of matrix-bound bone morphogenetic proteins (BMP-2 and BMP-7). To this end layer-by-layer films composed of poly(l-lysine) and hyaluronan were combined in a simple microfluidic device enabling spatially controlled growth factor diffusion along the film. Linear long-range gradients of both BMPs induced the trans-differentiation of C2C12 myoblasts towards the osteogenic lineage in a dose dependent manner with a different signature for each BMP. The osteogenic marker alkaline phosphatase (ALP) increased in a linear manner for BMP-7 and non-linearly for BMP-2. Moreover, an increased expression of the myogenic marker troponin T was observed with decreasing matrix-bound BMP concentration, providing a substrate that it is both osteo- and myo-inductive. Lastly, dual parallel matrix-bound gradients of BMP-2 and -7 revealed a complete saturation of the ALP signal. This suggested an additive or synergistic effect of the two BMPs. This simple technology allows for determining quickly and efficiently the optimal concentration of matrix-bound growth factors, as well as for investigating the presentation of multiple growth factors in their solid-phase and in a spatially controlled manner.
- Biomaterials.Biomaterials.2014 Apr;35(13):3975-85. doi: 10.1016/j.biomaterials.2014.01.012. Epub 2014 Jan 30.
- In the cellular microenvironment, growth factor gradients are crucial in dictating cell fate. Towards developing materials that capture the native microenvironment we engineered biomimetic films that present gradients of matrix-bound bone morphogenetic proteins (BMP-2 and BMP-7). To this end layer-b
- PMID 24485790
- Poly (glycerol sebacate) elastomer supports osteogenic phenotype for bone engineering applications.
- Zaky SH1, Hangadora CK, Tudares MA, Gao J, Jensen A, Wang Y, Sfeir C, Almarza AJ.Author information 1Department of Oral Biology, School of Dental Medicine, Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, USA.AbstractFor bone engineering, the optimal scaffolding material and composition has yet to be elucidated. In this study, we investigated poly (glycerol sebacate) (PGS), an elastomer known primarily for its soft tissue regeneration ability, as a suitable substrate to support osteo-precursor cell attachment and function. We synthesized PGS in the form of sheets where MC3T3-E1 cells were seeded in three different densities of 25 000, 50 000 and 100 000 cells mm(-3) and we investigated the cells/scaffold constructs for their cellular proliferation, matrix deposition, maturation, mineralization and their mechanical compression strength at 24 h and two and four weeks. MC3T3-E1 cells proliferated, synthesized a collagenous matrix and expressed osteogenic markers Runx2, bone sialoprotein and osteocalcin according to their initial seeding density on PGS. We conclude that PGS can support the osteoblastic phenotype in vitro and is a promising osteoconductive substrate for bone regeneration research and for future clinical translation.
- Biomedical materials (Bristol, England).Biomed Mater.2014 Apr;9(2):025003. doi: 10.1088/1748-6041/9/2/025003. Epub 2014 Jan 31.
- For bone engineering, the optimal scaffolding material and composition has yet to be elucidated. In this study, we investigated poly (glycerol sebacate) (PGS), an elastomer known primarily for its soft tissue regeneration ability, as a suitable substrate to support osteo-precursor cell attachment an
- PMID 24487088
- TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.
- Ruspi G1, Schmidt EM1, McCann F1, Feldmann M1, Williams RO1, Stoop AA2, Dean JL3.Author information 1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom.2Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge CB4 0WG, United Kingdom.3Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom. Electronic address: jonathan.dean@kennedy.ox.ac.uk.AbstractTumour necrosis factor (p55 or p60) receptor (TNFR) 1 is the major receptor that activates pro-inflammatory signalling and induces gene expression in response to TNF. Consensus is lacking for the function of (p75 or p80) TNFR2 but experiments in mice have suggested neuro-, cardio- and osteo-protective and anti-inflammatory roles. It has been shown in various cell types to be specifically required for the induction of TNFR-associated factor-2 (TRAF2) degradation and activation of the alternative nuclear factor (NF)-kappaB pathway, and to contribute to the activation of mitogen-activated protein kinases (MAPK) and the classical NF-kappaB pathway. We have investigated the signalling functions of TNFR2 in primary human and murine macrophages. We find that in these cells TNF induces TRAF2 degradation, and this is blocked in TNFR2(-/-) macrophages. TRAF2 has been previously reported to be required for TNF-induced activation of p38 MAPK. However, TRAF2 degradation does not inhibit TNF-induced tolerance of p38 MAPK activation. Neither TNF, nor lipopolysaccharide treatment, induced activation of the alternative NF-kappaB pathway in macrophages. Activation by TNF of the p38 MAPK and NF-kappaB pathways was blocked in TNFR1(-/-) macrophages. In contrast, although TNFR2(-/-) macrophages displayed robust p38 MAPK activation and IkappaBα degradation at high concentrations of TNF, at lower doses the concentration dependence of signalling was weakened by an order of magnitude. Our results suggest that, in addition to inducing TRAF2 protein degradation, TNFR2 also plays a crucial auxiliary role to TNFR1 in sensitising macrophages for the ligand-induced activation of the p38 MAPK and classical NF-kappaB pro-inflammatory signalling pathways.
- Cellular signalling.Cell Signal.2014 Apr;26(4):683-90. doi: 10.1016/j.cellsig.2013.12.009. Epub 2013 Dec 27.
- Tumour necrosis factor (p55 or p60) receptor (TNFR) 1 is the major receptor that activates pro-inflammatory signalling and induces gene expression in response to TNF. Consensus is lacking for the function of (p75 or p80) TNFR2 but experiments in mice have suggested neuro-, cardio- and osteo-protecti
- PMID 24378531
Japanese Journal
- Appeal to eye 骨の4Dイメージング(1)骨の4Dイメージング
- 菊田 順一,石井 優
- O.li.v.e. : osteo
- NAID 40020505811
- O.li.v.e. PLUS 学術講演会 第2回臨床骨ネットワーク研究会
- O.li.v.e. : osteo
- NAID 40020505795
- 骨の健康のために 食品におけるAGEs
- 山岸 昌一
- O.li.v.e. : osteo
- NAID 40020505751
Related Links
- osteo-とは。意味や和訳。「骨」osteoblast造骨細胞osteogenesis骨形成osteosarcoma骨肉腫(しゅ). - goo辞書は国語、英和、和英、中国語、百科事典等からまとめて探せる辞書検索サービスです。
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Related Pictures
★リンクテーブル★
| リンク元 | 「osseous」「os」 |
| 拡張検索 | 「osteonal」「osteophytosis」「osteosis eburnisans monomelica」 |
「osseous」
- adj.
- 骨の、骨様の
「os」
「osteonal」
- 骨単位の