潜在性脊髄閉鎖障害, OSD
WordNet
- work natural fibers into a thread; "spin silk"
- prolong or extend; "spin out a visit" (同)spin out
- the act of rotating rapidly; "he gave the crank a spin"; "it broke off after much twisting" (同)twirl, twist, twisting, whirl
- a distinctive interpretation (especially as used by politicians to sway public opinion); "the campaign put a favorable spin on the story"
- a short drive in a car; "he took the new car for a spin"
- a swift whirling motion (usually of a missile)
- revolve quickly and repeatedly around ones own axis; "The dervishes whirl around and around without getting dizzy" (同)spin around, whirl, reel, gyrate
- form a web by making a thread; "spiders spin a fine web"
- make up a story; "spin a yarn"
- stream in jets, of liquids; "The creek spun its course through the woods"
- twist and turn so as to give an intended interpretation; "The Presidents spokesmen had to spin the story to make it less embarrassing"
- hide from view; "The lids were occulting her eyes"
- supernatural practices and techniques; "he is a student of the occult" (同)occult arts
- become concealed or hidden from view or have its light extinguished; "The beam of light occults every so often"
- hidden and difficult to see; "an occult fracture"; "occult blood in the stool"
- of or relating to the spine or spinal cord; "spinal cord"; "spinal injury"
PrepTutorEJDIC
- (羊毛などから)〈糸など〉‘を'『紡ぐ』《+『名』+『out of』+『名』〈羊毛〉》,(糸などに)〈羊毛など〉‘を'紡ぐ《+『名』〈羊毛〉+『into』+『名』》 / 〈クモ・カイコなどが〉〈糸〉‘を'『吐く』;〈巣・繭〉‘を'かける / …‘を'くるくる回す / 〈物語など〉‘を'作る,話す / 『糸を紡ぐ』;〈クモ・カイコなどが〉糸を吐く / 〈こまなどが〉くるくる回る / 〈車などが〉疾走する / 〈頭などが〉くらくらする / 〈C〉〈U〉くるくる回すこと;回転 / 〈C〉《単数形で》(車などの)一走り / 〈C〉(飛行機の)きりもみ降下 / 〈C〉《単数形で》(価値などの)急落
- 秘法の / 人間の理解を越えた,神秘の / 超自然の世界
- 背骨の / せき髄麻酔
UpToDate Contents
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English Journal
- Vinyl Chloride Monomer (VCM) Induces High Occurrence of Neural Tube Defects in Embryonic Mouse Brain During Neurulation.
- Quan H1, Ma T, Zhao X, Zhao B, Liu Y, Li H.Author information 1Department of Histology and Embryology, Third Military Medical University, Gaotanyan St 30#, Shapingba District, Chongqing, 400038, People's Republic of China.AbstractThe aim of this study was to explore the direct embryonic teratogenicity of vinyl chloride monomer (VCM), especially the toxic effects on the early development of the nervous system and its underlying mechanisms. Pregnant mice at embryonic day 6.5 (E6.5) were injected with different doses of VCM (200, 400 and 600 mg/kg) and embryos were harvested at E10.5. Our results showed that doses higher than 400 mg/kg of VCM increased the incidence of malformed embryos, especially the neural tube defects (NTDs). In addition, high-dose of VCM decreased mitotic figure counts in the neuroepithelium and enhanced the percentage of cells in G0/G1 phase, while they were reduced in S phase. The more VCM was injected into mice, the fewer positive PCNA cells were seen and the more positive TUNEL cells were observed in the neuroepithelium. Moreover, significant increases in the levels of caspase-3 protein were observed in NTD embryos. Our results demonstrate that during early pregnancy, exposure to doses higher than 400 mg/kg of VCM increases the incidence of malformations and particularly the rate of NTDs. High-dose of VCM inhibits the proliferation of neural cells and induces cell apoptosis, leading to an imbalance in the ratio of proliferation and apoptosis. Meanwhile, the apoptosis of neuroepithelial cells might be accelerated by the activation of the caspase-3 pathway, and it might be a reason for NTDs.
- Cellular and molecular neurobiology.Cell Mol Neurobiol.2014 May;34(4):619-30. doi: 10.1007/s10571-014-0049-6. Epub 2014 Mar 25.
- The aim of this study was to explore the direct embryonic teratogenicity of vinyl chloride monomer (VCM), especially the toxic effects on the early development of the nervous system and its underlying mechanisms. Pregnant mice at embryonic day 6.5 (E6.5) were injected with different doses of VCM (20
- PMID 24664314
- Concentrations of selected heavy metals in maternal blood and associated factors in rural areas in Shanxi Province, China.
- Jin L1, Liu J1, Ye B2, Ren A3.Author information 1Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, PR China.2Institute for Environment Hygiene and Health Related Product Safety, Chinese Center for Disease Control and Prevention, PR China.3Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, PR China. Electronic address: RenAG@bjmu.edu.cn.AbstractBACKGROUND: Animal experiments indicate that prenatal exposure to mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) can induce fetal neural tube defects (NTDs). The objectives of this study were to determine the levels of maternal exposure to Hg, Pb, Cd and As during early pregnancy in rural areas of Shanxi Province, China, in order to explore factors that were associated with the concentrations of these metals in blood.
- Environment international.Environ Int.2014 May;66:157-64. doi: 10.1016/j.envint.2014.01.016. Epub 2014 Mar 2.
- BACKGROUND: Animal experiments indicate that prenatal exposure to mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) can induce fetal neural tube defects (NTDs). The objectives of this study were to determine the levels of maternal exposure to Hg, Pb, Cd and As during early pregnancy in rural ar
- PMID 24584080
- Association of folic Acid supplementation during pregnancy and infant bronchiolitis.
- Veeranki SP, Gebretsadik T, Dorris SL, Mitchel EF, Hartert TV, Cooper WO, Tylavsky FA, Dupont W, Hartman TJ, Carroll KN.AbstractViral bronchiolitis affects 20%-30% of infants; because there is no known effective treatment, it is important to identify risk factors that contribute to its pathogenesis. Although adequate folate intake during the periconceptional period prevents neural tube defects, animal data suggest that higher supplementation may be a risk factor for child respiratory diseases. Using a population-based retrospective cohort of 167,333 women and infants, born in 1995-2007 and enrolled in the Tennessee Medicaid program, we investigated the association between the filling of folic acid-containing prescriptions and infant bronchiolitis. We categorized women into the following 4 groups in relation to the first trimester: "none" (no prescription filled), "first trimester only," "after first trimester," and "both" (prescriptions filled both during and after the first trimester). Overall, 21% of infants had a bronchiolitis diagnosis, and 5% were hospitalized. Most women filled their first prescriptions after the fifth to sixth weeks of pregnancy, and most prescriptions contained 1,000 µg of folic acid. Compared with infants born to women in the "none" group, infants born to women in the "first trimester only" group had higher relative odds of bronchiolitis diagnosis (adjusted odds ratio = 1.17, 95% confidence interval: 1.11, 1.22) and greater severity (adjusted odds ratio = 1.16, 95% confidence interval: 1.11, 1.22). This study's findings contribute to an understanding of the implications of prenatal nutritional supplement recommendations for infant bronchiolitis.
- American journal of epidemiology.Am J Epidemiol.2014 Apr 15;179(8):938-46. doi: 10.1093/aje/kwu019. Epub 2014 Mar 12.
- Viral bronchiolitis affects 20%-30% of infants; because there is no known effective treatment, it is important to identify risk factors that contribute to its pathogenesis. Although adequate folate intake during the periconceptional period prevents neural tube defects, animal data suggest that highe
- PMID 24671071
Japanese Journal
- 腰仙部皮膚陥凹 (特集 これが大切! 1カ月以内の新生児疾患) -- (見落としてはならない重症疾患・対応に迷う疾患)
- いわゆる仙尾部皮膚陥凹と合併する潜在性二分脊椎のMRIによる検討
Related Links
- Tethered spinal cord syndrome or occult spinal dysraphism sequence refers to a group of neurological disorders related to malformations of the spinal cord. The various forms include: tight filum terminale, lipomeningomyelocele, split cord ...
- The term occult spinal dysraphism (OSD) encompasses a group of abnormalities that occur during the development of a human embryo, beginning in the second week of gestation. They are the result of incomplete or incorrect formation of the ...
★リンクテーブル★
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- 英
- occult spinal dysraphism
- 同
- 潜在性脊椎閉鎖不全症 潜在性脊椎癒合不全、潜在性二分脊椎症
- ラ
- spina bifida occulta
- 関
- 二分脊椎、occult spinal dysraphism
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- 英
- occult spinal dysraphism, OSD
- 関
- spina bifida occulta, 潜在性二分脊椎
[★]
- 英
- occult spinal dysraphism
- 関
- 潜在性二分脊椎
[★]
潜在性脊髄閉鎖障害 occult spinal dysraphism
[★]
- 関
- dorsal spine、rachis、spinal column、spinal cord、spine、vertebral column
[★]
- 関
- cryptic、initiated、latency、latent、subclinical
[★]
脊椎癒合不全、脊髄癒合不全
- 関
- spina bifida
[★]
[★]
閉鎖不全
- 関
- dysraphicus