a part of the cell containing DNA and RNA and responsible for growth and reproduction (同)cell_nucleus, karyon
(astronomy) the center of the head of a comet; consists of small solid particles of ice and frozen gas that vaporizes on approaching the sun to form the coma and tail
any histologically identifiable mass of neural cell bodies in the brain or spinal cord
the positively charged dense center of an atom
belonging to or on or near the back or upper surface of an animal or organ or part; "the dorsal fin is the vertical fin on the back of a fish and certain marine mammals"
Diagram showing a few of the connections of afferent (sensory) fibers of the posterior root with the efferent fibers from the ventral column and with the various long ascending fasciculi. (Dorsal nucleus labeled at center right.)
Schematic of spinal cord grey matter showing location of the Dorsal Nucleus
Details
Identifiers
Latin
nucleus thoracicus posterior, nucleus dorsalis
TA
A14.1.02.135
FMA
73912
Anatomical terminology
[edit on Wikidata]
The posterior thoracic nucleus, (Clarke's column, column of Clarke, dorsal nucleus, nucleus dorsalis of Clarke) is a group of interneurons found in the medial part of lamina VII, also known as the intermediate zone, of the spinal cord. It is mainly located from the cervical vertebra C7 to lumbar L3-L4 levels and is an important structure for proprioception[1] of the lower limb.
Contents
1Anatomy
2Function
3Diseases
4Eponym
5References
6External links
Anatomy
It occupies the medial part of the base of the posterior grey column and appears on the transverse section as a well-defined oval area.
It begins caudally at the level of the second or third lumbar nerve, and reaches its maximum size opposite the twelfth thoracic nerve. Above the level of the eight thoracic nerve its size diminishes, and the column ends opposite the last cervical or first thoracic nerve.
It is represented, however, in the other regions by scattered cells, which become aggregated to form a cervical nucleus opposite the third cervical nerve, and a sacral nucleus in the middle and lower part of the sacral region.
Nerve cells in the posterior thoracic nucleus are most abundant between the lower thoracic and upper lumbar segments. Cell bodies are of medium size and oval- or pyriform-shape. These cells characteristically present coarse Nissl granules and have characteristic eccentric nuclei.[2]
Axonal projections from neurons in this nucleus give rise to the dorsal spinocerebellar tract which ascends ipsilaterally through the spinal cord and ends as mossy fibers in the ipsilateral cerebellar cortex after passing through the inferior cerebellar peduncle.[3]
Axons originating from the posterior thoracic nucleus which ascend contralaterally through the lateral funiculus of the spinal cord are named ventral spinocerebellar tract which cross over again within the brainstem to end on the ipsilateral side.
Function
The posterior thoracic nucleus is a major relay center for unconscious proprioception. Sensory information from muscle spindles and tendon organs is carried by axons of larger neurons in posterior root ganglia, which synapse onto neurons in the spinal cord including the posterior thoracic nucleus. From here information continues rostrally until it reaches the cerebellar cortex. This relay pathway is generally known as the dorsal spinocerebellar tract.
Diseases
It has been observed that in Friedreich's ataxia there is evident degeneration of the posterior thoracic nucleus as well as other proprioceptive spinal tracts. These patients might present with ataxia, dysarthria, muscle weakness or paralysis and skeletal defects.[4]
Eponym
Clarke's column is named for Jacob Augustus Lockhart Clarke.[5][6]
References
^University of Wisconsin http://www.neuroanatomy.wisc.edu/sc97/text/p3/Pathway.htm. Retrieved 4 May 2018. Missing or empty |title= (help)
^Carpenter, Malcolm (1991). Core text of Neuroanatomy. Baltimore, Maryland: Williams & Wilkins. p. 70. ISBN 0683014579.
^Blumenfeld, Hal (2010). Neuroanatomy through Clinical Cases. MA: Sinauer. pp. 709–710. ISBN 9780878930586.
^Haines, Duane (2008). Neuroanatomy an Atlas of Structures, Sections and Systems. PA: Lippincott Williams & Wilkins. pp. 222–223. ISBN 978-0781763288.
^synd/2143 at Who Named It?
^J. A. L. Clarke. Researches into the structure of the spinal cord. Philosophical Transactions of the Royal Society of London, 1851, 141: 607-621.
5. 抗核抗体染色パターンおよび関連自己抗体の臨床的意義 clinical significance of antinuclear antibody staining patterns and associated autoantibodies
English Journal
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Mota CMD, Rodrigues-Santos C, Carolino ROG, Anselmo-Franci JA, Branco LGS.
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Lin JY, Zhu N, He YN, Xu BL, Peng B.
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Painful diabetic neuropathy may associate with nerve morphological plasticity in both peripheral and central nervous system. The aim of this study was to determine numerical changes of myelinated fibers in the spinothalamic tract region and oligodendrocytes in the spinal dorsal horn of rats with pai
Aquaporin 4 knockout increases complete freund's adjuvant-induced spinal central sensitization.
Wang C, Wu Q, Wang Z, Hu L, Marshall C, Xiao M.
Brain research bulletin. 2020 Mar;156()58-66.
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Englisch: posterior thoracic nucleus 1 Definition Der Nucleus dorsalis ist eine säulenförmige Ganglienzellgruppe bzw. ein Kerngebiet in der grauen Substanz des Rückenmarks in den Laminae 5 und 6 des Hinterhorns. Er wird 2 C8
Medical definition of nucleus dorsalis: an elongated longitudinal strand of neurons in the spinal cord with its axons passing into the cerebellar tract —called also Clarke's column. ... Cite this Entry “Nucleus dorsalis.” The Merriam ...
The nucleus raphe dorsalis consists of rostral and caudal subdivisions. The rostral aspect of the dorsal raphe is further divided into interfascicular, ventral, ventrolateral and dorsal subnuclei. The projections of the dorsal raphe have ...