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any of several substances found in the nuclei of all living cells; consists of a protein bound to a nucleic acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/15 19:37:02」(JST)

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Nucleoproteins are any proteins that are structurally associated with nucleic acids^[1]either DNA or RNA.

Nucleoproteins are complex proteins in which the polypeptide chain is non-covalently attached to the nucleic acid. Typical nucleoproteines are ribosomes, nucleosomes and all viruses. Ribosomes are ribonucleoproteins. In prokaryotes have been built by three, and in eukaryotes of four different molecules of ribonucleic acid (RNA) and one molecule of each of the 50 or more ribosomal proteins. Nucleosomes are deoksiribonukleoproteini, with proteins that contain deoxyribonucleic acid (DNA). Some viruses are simple ribonucleoproteins, containing only one molecule of RNA and a number of mutually identical protein molecules, while others are ribonucleoproteins or deoksiribonucleoprotein complex structure and contain a number of different proteins, and exceptionally more nucleic acid molecules. Crystallographic methods many nucleoprotein specific spatial structure and biological function understood.^[2]^[3]

Examples

The prototypical example is any of the histone class of proteins, which are identifiable on strands of chromatin. Telomerase, a RNP (RNA/protein complex), and Protamines are also nucleoproteins.

References

^ Nucleoproteins at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Graeme K. Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
^ Nelson D. L., Cox M. M. (2013): Lehninger Biochemie. Springer, ISBN 978-3-540-68637-8.

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2. 様々な抗核抗体 miscellaneous antinuclear antibodies
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English Journal

Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitro.

Chen X1, Zha GF2, Wang JQ1, Liu XH1,3.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2018 Dec;33(1):1266-1270. doi: 10.1080/14756366.2018.1484735.
PMID 30139286

Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin.

Quan Wang J1, Di Yang M1, Chen X1, Wang Y1, Zeng Chen L1, Cheng X1, Hua Liu X1,2.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2018 Dec;33(1):1199-1211. doi: 10.1080/14756366.2018.1466881.
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Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers.

Chamorro-Petronacci C1, Perez-Sayáns M1, Padín-Iruegas ME2, Marichalar-Mendia X3, Gallas-Torreira M1, García García A1.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2018 Dec;33(1):424-427. doi: 10.1080/14756366.2018.1426574.
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Japanese Journal

株化細胞におけるSiniperca chuatsi rhabdovirusのRNA干渉法による複製阻害

Zhou Guang-Zhou,Zhu Rong,Gui ian-Fang [他]
魚病研究 47(1), 30-32, 2012-03
NAID 40019314719

Taxonomy of DNA Conformations within Complex Nucleoprotein Assemblies(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)

BUCK Dorothy,BAKER Kenneth Lee
Progress of theoretical physics. Supplement (191), 55-65, 2011-12-16
… Here we discuss the paradigms both for modelling complex nucleoprotein assemblies as rational tangles, and the associated enzymatic action as rational subtangle replacement. …
NAID 110008798526

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★リンクテーブル★

リンク元	「核タンパク質」「nuclear protein」「核蛋白質」「核タンパク」
拡張検索	「heteronuclear ribonucleoprotein」「small nuclear ribonucleoprotein」「heterogeneous-nuclear ribonucleoprotein U」「heterogeneous-nuclear ribonucleoprotein group A-B」「heterogeneous-nuclear ribonucleoprotein group F-H」