心筋抑制因子
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- capable of depressing physiological or psychological activity or response by a chemical agent
- of or relating to the myocardium
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- 機能低下剤,鎮静剤,抑制剤 / 鎮静効果のある / 意気消沈させる / 物価を抑制する
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/06 17:36:12」(JST)
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This article needs attention from an expert in medicine. Please add a reason or a talk parameter to this template to explain the issue with the article. WikiProject Medicine (or its Portal) may be able to help recruit an expert. (November 2008) |
Myocardial depressant factor (MDF) or Myocardial Toxic factor (MTF) is a low-molecular-weight peptide[1] released from the pancreas into the blood in mammals during various shock states.[2]
MDF is a significant mediator of shock pathophysiology, reducing myocardial contractility, constricting splanchnic arteries and impairing phagocytosis by the reticuloendothelial system. Survival can be improved by preventing its release or blocking its activity, for example using glucocorticoids, prostaglandins, aprotinin, captopril, imidazole or lidocaine.
References
- ^ Myocardial Depressant Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Lefer AM (July 1982). "The pathophysiologic role of myocardial depressant factor as a mediator of circulatory shock". Klin. Wochenschr. 60 (14): 713–6. doi:10.1007/BF01716561. PMID 6181287.
UpToDate Contents
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- 1. 急性膵炎の発症機序 pathogenesis of acute pancreatitis
English Journal
- Aqueous-methanolic extract of sweet flag (Acorus calamus) possesses cardiac depressant and endothelial-derived hyperpolarizing factor-mediated coronary vasodilator effects.
- Shah AJ, Gilani AH.SourceNatural Products Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan.
- Journal of natural medicines.J Nat Med.2012 Jan;66(1):119-26. doi: 10.1007/s11418-011-0561-7. Epub 2011 Aug 9.
- This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases. Effect on heart parameters was studied in isolated rabbit heart while coronary vasodilator effect was studied in isolated bovine coronary arterial rings, suspended in tissue
- PMID 21826570
- Transforming growth factor-alpha does not protect myocardium during acute ischemia/reperfusion.
- Manukyan MC, Keck AC, Poynter JA, Wang Y, Weil BR, Abarbanell AM, Herrmann JL, Crowe BJ, Alvernaz C, Meldrum DR.SourceDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- Surgery.Surgery.2011 Aug;150(2):339-46. doi: 10.1016/j.surg.2011.05.018.
- BACKGROUND: The activation of the epidermal growth factor family of receptors may improve cardiac protection after injury. One epidermal growth factor family ligand, transforming growth factor-alpha, promotes wound healing in multiple tissues in response to oxidative injury and might confer resistan
- PMID 21801969
- Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase.
- Pathan N, Franklin JL, Eleftherohorinou H, Wright VJ, Hemingway CA, Waddell SJ, Griffiths M, Dennis JL, Relman DA, Harding SE, Levin M.SourceDepartment of Paediatrics, Imperial College London, London, UK. n.pathan@imperial.ac.uk
- Critical care medicine.Crit Care Med.2011 Jul;39(7):1692-711. doi: 10.1097/CCM.0b013e3182186d27.
- OBJECTIVES: Myocardial failure, leading to inotrope-unresponsive shock, is the predominant cause of death in meningococcal and other forms of septic shock. Proinflammatory cytokines released in septic shock are known to have myocardial depressant effects. We previously showed that interleukin 6 is a
- PMID 21494108
Japanese Journal
- Delayed Appearance of Circulating Myocardial Depressant Factor in Burn Patients
- 急性膵炎時における血中 β-glucuronidase の変動と Cardiac function
- 佐竹 克介,西村 茂彦,梅山 馨,謝 直道,藤森 貢
- 日本消化器外科学会雑誌 11(1), 119-126, 1978-01-30
- … 近年, 種々の shock 時にみられる myocardial depressant factor (M.D.F) の産生は, 膵血流量低下による膵の Ischemia および膵障害により遊離される lysosomal enzyme と密接の関係があると推測されている. …
- NAID 110001359398
- Pathophysiology of Shock : SYMPOSIUM ON TREATMENT OF SHOCK
- Okada Kazuo [他],KOSUGI ISAO,KITAGAKI TERUO,YAMAGUCHI YOSHIHARU,YOSHIKAWA HIDEYASU,KAWASHIMA YASUO,KAWAKAMI SYUNJI,YOSHIMASA SENOH
- 日本循環器学誌 41(4), 346-361, 1977-05-20
- … Myocardial depressant factor was identified both in plasma and pancreas in advanced shock. … Gel-chormatographic analysis was applied to separate the myocardial depressant factor. … It is also demonstrated that myocardial depressant factor was produced in pancreas, transported via blood stream to the hear and caused cardiac depression. …
- NAID 110002583238
Related Links
- myocardial depressant factor n. Abbr. MDF A toxic factor in shock that impairs cardiac contractility. myocardial depressant factor Uncertain; a substance allegedly present in the circulation that was once thought to be responsible for ...
- Translations of myocardial depressant factor. myocardial depressant factor synonyms, myocardial depressant factor antonyms. Information about myocardial depressant factor in the free online English dictionary and encyclopedia. ...
★リンクテーブル★
[★]
[★]
- 英
- myocardial depressant factor、MDF
- 関
- 心筋収縮抑制ペプチド
[★]
- 英
- myocardial depressant factor
- 関
- 心筋抑制因子
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
- 関
- anti-arrhythmia agent、antiarrhythmic drug、cardiac depressant
[★]
- 関
- cardiac muscle、heart muscle、myocardia、myocardium
[★]
- 心筋
- 関
- cardiac muscle、heart muscle、myocardial、myocardium