mucosal neuroma syndrome

粘膜神経腫、粘膜神経腫症候群

WordNet

1. a pattern of symptoms indicative of some disease
2. a complex of concurrent things; "every word has a syndrome of meanings"
3. of or relating to mucous membranes
4. any tumor derived from cells of the nervous system

PrepTutorEJDIC

1. (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

UpToDate Contents

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• 1. 多発性内分泌腫瘍2型の臨床症状および診断 clinical manifestations and diagnosis of multiple endocrine neoplasia type 2
• 2. 多発性内分泌腫瘍2型の分類および遺伝学 classification and genetics of multiple endocrine neoplasia type 2
• 3. Medullary thyroid cancer: Clinical manifestations, diagnosis, and staging
• 4. 小児における甲状腺結節および癌 thyroid nodules and cancer in children
• 5. ガングリオンと結節 ganglia and nodules

English Journal

• Diagnosis and preoperative imaging of multiple endocrine neoplasia type 2: current status and future directions.

• Taïeb D1, Kebebew E, Castinetti F, Chen CC, Henry JF, Pacak K.
• Clinical endocrinology.Clin Endocrinol (Oxf).2014 Sep;81(3):317-28. doi: 10.1111/cen.12513. Epub 2014 Jun 28.
• Multiple endocrine neoplasia type 2 (MEN2) is a rare autosomal dominant syndrome caused by mutations in the RET protooncogene and is characterized by a strong penetrance of medullary thyroid carcinoma (all subtypes) and is often accompanied by pheochromocytoma (MEN2A/2B) and primary hyperparathyroid
• PMID 24889858

• Laryngeal neuroma in multiple endocrine neoplasia type 2B.

• Kudo N1, Matsubara A2, Abe T1, Inoue T1, Takahata J1.
• Auris, nasus, larynx.Auris Nasus Larynx.2014 Aug;41(4):389-91. doi: 10.1016/j.anl.2013.12.007. Epub 2014 Jan 2.
• Multiple endocrine neoplasia (MEN) type 2 syndrome is an autosomal dominant inherited disease caused by mutations of the RET proto-oncogene, and is clinically divided into three phenotypes: MEN2A, MEN2B, and familial medullary thyroid carcinoma. Although multiple mucosal neuromas are commonly observ
• PMID 24389350

• The relationship between palisaded encapsulated neuroma and the mucocutaneous neuroma seen in multiple endocrine neoplasia 2b syndrome: a histopathologic and immunohistochemical study.

• Misago N1, Toda S, Narisawa Y.
• The American Journal of dermatopathology.Am J Dermatopathol.2014 Jul;36(7):562-9. doi: 10.1097/DAD.0000000000000021.
• A relationship between the palisaded encapsulated neuroma (PEN) and the mucocutaneous neuroma seen in multiple endocrine neoplasia (MEN) 2b syndrome has been noted. We experienced a case of multiple mucocutaneous neuromas including both MEN 2b type neuromas and PENs. We evaluated the histopathologic
• PMID 24247580

Japanese Journal

• 顎変形症の手術を契機に発見された多発性内分泌腺腫症2B型 (MEN 2B) 例

• 栗原 理紗,篠原 尚吾,菊地 正弘,藤原 敬三,山崎 博司,金沢 佑治,岸本 逸平,内藤 泰
• 耳鼻咽喉科臨床 104(5), 365-369, 2011-05-01
• … Multiple endocrine neoplasia type 2B (MEN 2B), an autosomal dominant syndrome, involves endocrine tumors caused by RET protooncogene germ-line mutations in chromosome 10. … In surgery, his somewhat abnormal buccal mucosa and mandible were biopsied and pathological findings indicated multiple mandibular and buccal mucosal neuromas suggesting de novo MEN 2B. …
• NAID 10027972675

• 多発性内分泌腫瘍症(MEN2B)に伴う口腔粘膜神経腫の1例

• 佐藤 秀人,太田 和俊,大林 武久,右山 裕則,牧 正啓,篠原 正徳
• 日本口腔外科学会雑誌 49(4), 276-279, 2003-04-20
• … MEN 2 B is characterized by medullary thyroid carcinoma, pheochromocytomas, mucosal neuromas, ganglioneuromas of the intestinal tract, and Marfans syndrome. … Histological and immunohistochemical studies (HE, S-100 protein and NSE) showed hyperplasia and hypertrophy of nerves, suggesting neuroma. … Failure to recognize the syndrome may have unfortunate consequences for the patient, since proper treatment of the thyroid tumor that may arise in childhood will not be provided. …
• NAID 10012629123

Related Links

• mucosal neuroma syndrome | Hereditary Ocular Diseases

This website contains a database of hereditary disorders with important ocular features. It is a point-of-service portal site, designed specifically for clinical ophthalmologists for quick reference during office hours. Each description of a ...

• Mucosal neuroma syndrome--a phenotype for malignancy.

Norton JA, Froome LC, Farrell RE, Wells SA., Jr Multiple endocrine neoplasia type IIb: the most aggressive form of medullary thyroid carcinoma. Surg Clin North Am. 1979 Feb; 59 (1):109–118. [PubMed] Khairi MR, Dexter RN ...

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★リンクテーブル★

リンク元	「粘膜神経腫」「MEN 3」「MEN2B」「粘膜神経腫症候群」
関連記事	「neuro」「mucosal」「syndrome」

「粘膜神経腫」

　　[★]

英

mucosal neuroma

関

多発性内分泌腫瘍症2B型 MEN 2B MEN2B multiple endocrine neoplasia type 2B

粘膜神経腫症候群 mucosal neuroma syndrome、多発性粘膜神経腫 multiple mucosal neuroma

参考

• 写真

http://archpedi.ama-assn.org/content/vol155/issue7/images/medium/ppm0012f1.jpg

http://archpedi.ama-assn.org/content/vol155/issue7/images/medium/ppm0012f2.jpg

http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?cat3=1746

「MEN 3」

　　[★]

多発性内分泌腫瘍症3型、多発性内分泌腺腫症3型

関

MEN 2B、MEN2B、mucosal neuroma syndrome、multiple endocrine neoplasia type 2B、multiple endocrine neoplasia type 3

「MEN2B」

　　[★]

多発性内分泌腫瘍症2B型、多発性内分泌腺腫症2B型

関

MEN 2B、MEN 3、mucosal neuroma syndrome、multiple endocrine neoplasia type 2B

「粘膜神経腫症候群」

　　[★]

英

mucosal neuroma syndrome

関

多発性内分泌腺腫症2B型、多発性内分泌腫瘍症3型

「neuro」

　　[★]

• comb form.

• ニューロ、神経

関

nerve、nervi、nervous、nervus、neural、neuron

「mucosal」

　　[★]

• adj.

• 粘膜の

関

mucosa、mucosae、mucous、mucous membrane

　

「syndrome」

　　[★]

• n.

• 症候群