microcytic anemia

小球性貧血

WordNet

1. a deficiency of red blood cells (同)anaemia
2. a lack of vitality (同)anaemia
3. genus of terrestrial or lithophytic ferns having pinnatifid fronds; chiefly of tropical America (同)genus Anemia

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/22 13:38:07」(JST)

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Microcytic anemia
Classification and external resources
ICD-10	D50.8

Microcytic anemia (BrE: anaemia) is a generic term for any type of anemia characterized by small red blood cells. The normal mean corpuscular volume (abbreviated to MCV on full blood count results) is 76-100 fL, with smaller cells (<76 fL) described as microcytic and larger cells (>100 fL) as macrocytic.

In microcytic anemia, the red blood cells (erythrocytes) are usually also hypochromic, meaning that the red blood cells are paler than usual. This can be quantified as the mean corpuscular hemoglobin or mean cell hemoglobin (MCH), the amount of hemoglobin per cell; the normal value is 27-32 picograms (pg). Similar is the mean corpuscular hemoglobin concentration (MCHC), giving the amount of hemoglobin per volume of erythrocytes (normally about 320-360 g/L or 32-36 g/dL). Typically, therefore, anemia of this category is described as "microcytic, hypochromic anemia".

Causes

Typical causes of microcytic anemia include:

• childhood
  • iron deficiency anemia, by far the most common cause of anemia in general and of microcytic anemia in particular
  • thalassemia
• adulthood
  • blood loss
  • iron deficiency anemia
  • sideroblastic anemia, congenital or acquired
  • anemia of chronic disease, although this more typically causes normochromic, normocytic anemia. Microcytic anemia has been discussed by Weng et al.
  • lead poisoning
  • pyridoxine deficiency

Other causes that are "typically" thought of as causing normocytic anemia or macrocytic anemia must also be considered, and the presence of two or more causes of anemia can distort the "typical" picture.

See also

• Hypochromic anemia

References

External links

• Emedicine on chronic anemia

UpToDate Contents

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• 1. 小赤血球症/小球性貧血 microcytosis microcytic anemia
• 2. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
• 3. 貧血を有する小児に対するアプローチ approach to the child with anemia
• 4. 成人の鉄欠乏症および鉄欠乏性貧血の原因と診断 causes and diagnosis of iron deficiency and iron deficiency anemia in adults
• 5. サラセミアの臨床症状および診断 clinical manifestations and diagnosis of the thalassemias

English Journal

• Characterization of deletional and non-deletional alpha globin variants in a large cohort from Spain between 2009 and 2014.

• de la Fuente-Gonzalo F, Nieto JM, Villegas A, González FA, Martínez R, Ropero P.
• Annals of hematology. 2019 Jul;98(7)1537-1545.
• The hemoglobinopathies are a group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule. They are among the most common inherited diseases around the world. Those that produce abnormal hemoglobin are called structural hem
• PMID 31025160

• Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer.

• McSorley ST, Tham A, Steele CW, Dolan RD, Roxburgh CS, Horgan PG, McMillan DC.
• European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2019 Jul;45(7)1205-1211.
• Inflammation is recognised to be associated with perturbation of serum measures of iron status. However, the impact of colorectal cancer associated host inflammation on red cell measures of iron status has not been previously quantified. Patients undergoing elective surgery with curative intent, for
• PMID 30850153

• Iron Refractory Iron Deficiency Anemia Due to 374 Base Pairs Deletion in the TMPRSS6 Gene.

• Çakmakli S, Acipayam C, Yenmiş İnan MN, Doğan H.
• Journal of pediatric hematology/oncology. 2019 Jul;41(5)e333-e335.
• Iron refractory iron deficiency anemia is an autosomal recessive disorder arising from defects in iron metabolism that cause microcytic anemia to grow resistant to treatment. The patients usually do not respond to orally administered iron treatment and partially respond to intravenous iron administr
• PMID 30130276

Japanese Journal

• 鉄剤不応性の鉄欠乏性貧血

• 臨床血液 57(2), 104-109, 2016
• NAID 130005132711

• 症例報告 経過中に小球性貧血をきたした低亜鉛母乳による亜鉛欠乏症の1例

• 臨床皮膚科 = Japanese journal of clinical dermatology 69(10), 742-745, 2015-09
• NAID 40020566119

• Relationships Among Red Cell Distribution Width, Anemia, and Interleukin-6 in Adult Congenital Heart Disease

• Circulation Journal 79(5), 1100-1106, 2015
• NAID 130005066270

Related Links

• Microcytic Anemia — NEJM - The New England Journal of ...

Microcytic anemia is characterized by smaller-than-normal red cells due to decreased production of hemoglobin. This review discusses diagnosis and treatment of thalassemia, anemia of inflammation, and iron-deficiency ...

• Microcytic Anemia Info | Microcytic Anemia

Microcytic anemia is one of the most common problems faced in the primary care physician’s office, and for many patients is synonymous with iron deficiency anemia. In fact the most common cause of microcytic anemia is iron ...

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★リンクテーブル★

リンク元

「小球性貧血」

「小球性貧血」

　　[★]

英

microcytic anemia

ラ

anaemia microcytica

関

貧血、小球性低色素性貧血、低色素性貧血

概念

• 平均赤血球容積(MCV)が基準値以下(MCVが80fL以下)の赤血球を呈する貧血を指す総称である。

治療反応性による鑑別

• 鉄剤有効：鉄欠乏性貧血
• 鉄剤無効：サラセミア、無トランスフェリン血症、？慢性疾患による貧血？

HbA1cとの関連

• 赤血球産生が低下するために、代償的に赤血球寿命が延長し、その結果HbA1cが高値となる。しかし、血糖値高値を反映していないために、偽陽性となる。