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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/28 21:11:35」(JST)

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Metildigoxin (INN, or medigoxin BAN, or methyldigoxin) is a cardiac glycoside,^[1] a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). The substance is closely related to digoxin; it differs from the latter only by an O-methyl group on the terminal monosaccharide.

References

^ Hayward, R.; Greenwood, H.; Stephens, J.; Hamer, J. (1983). "Relationship between myocardial uptake and actions in heart failure of methyldigoxin". British Journal of Clinical Pharmacology 15 (1): 41–48. PMC 1427830. PMID 6849743. edit

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English Journal

Analysis of digoxin and metildigoxin in whole blood using solid-phase extraction and liquid chromatography tandem mass spectrometry.

Melo P, Machado R, Teixeira HM.SourceNational Institute of Legal Medicine, North Branch, 4050-167 Porto, Portugal.
International journal of analytical chemistry.Int J Anal Chem.2012;2012:975824. doi: 10.1155/2012/975824. Epub 2011 Jun 22.
A simple and rapid UPLC/MS/MS method has been developed and validated for the analysis of digoxin and metildigoxin in whole blood. Samples were prepared by SPE extraction with Oasis HLB columns. Separation was achieved with an ACQUITY UPLC HSS T3 column (2.1 × 100; 1.8 μm), at 35°C. The mobile
PMID 21776271

Free and total digoxin in serum during treatment of acute digoxin poisoning with Fab fragments: case study.

Eyer F, Steimer W, Müller C, Zilker T.SourceDepartment of Clinical Toxicology at Technische Universität, Munich, Germany. Florian.Eyer@t-online.de
American journal of critical care : an official publication, American Association of Critical-Care Nurses.Am J Crit Care.2010 Jul;19(4):391-87. doi: 10.4037/ajcc2009227. Epub 2009 Oct 29.
A woman ingested 10 mg of methyldigoxin in a suicide attempt and presented 19 hours after ingestion with clinical signs of glycoside intoxication. Her serum level of digoxin was 7.4 ng/mL, and antidotal therapy with Fab antibody fragments was started. The manufacturer's recommended dosing scheme was
PMID 19875723

Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system.

Balenovic D, Bencic ML, Udovicic M, Simonji K, Hanzevacki JS, Barisic I, Kranjcevic S, Prkacin I, Coric V, Brcic L, Coric M, Brcic I, Borovic S, Radic B, Drmic D, Vrcic H, Seiwerth S, Sikiric P.SourceDepartment of Pharmacology, University of Zagreb Medical School, Salata 11, 10000 Zagreb, Croatia.
Regulatory peptides.Regul Pept.2009 Aug 7;156(1-3):83-9. doi: 10.1016/j.regpep.2009.05.008. Epub 2009 May 22.
Pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419) reversed congestive heart failure and various arrhythmias, influenced the NO-system and showed no proarrhythmic effect. In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and
PMID 19465062

Japanese Journal

Effect of Metildigoxin (β-Methyldigoxin) on Congestive Heart Failure as Evaluated by Multiclinical Double Blind Study

Kimura Eiichi,Sakuma Akira
Ｊａｐａｎｅｓｅ　Ｈｅａｒｔ　Ｊｏｕｒｎａｌ 21(1), 47-57, 1980
… The efficacy on congestive heart failure of metildigoxin (β-methyldigoxin, MD), a derivative of digoxin (DX), which had a good absorption rate from digestive tract, was examined in a double blind study using a group comparison method. …
NAID 130000762001

Related Pictures

★リンクテーブル★

リンク元	「メチルジゴキシン」「medigoxin」

「メチルジゴキシン」

Metildigoxin
Systematic (IUPAC) name
	(3β,5β,12β)-3-{[2,6-dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C
Legal status	?
Identifiers
CAS number	30685-43-9
ATC code	C01AA08
PubChem	CID 443946
ChemSpider	392000
UNII	I7GG1YUC5V
Synonyms	4-[(3S,5R,8R,9S,10S,12R,13S,14S)-12,14-Dihydroxy-3-[(2R,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-methoxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Chemical data
Formula	C42H66O14
Mol. mass	794.965
	SMILES O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](OC)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6;
	InChI InChI=1S/C42H66O14/c1-20-37(49-6)29(43)16-35(51-20)55-39-22(3)53-36(18-31(39)45)56-38-21(2)52-34(17-30(38)44)54-25-9-11-40(4)24(14-25)7-8-27-28(40)15-32(46)41(5)26(10-12-42(27,41)48)23-13-33(47)50-19-23/h13,20-22,24-32,34-39,43-46,48H,7-12,14-19H2,1-6H3/t20-,21-,22-,24-,25+,26-,27-,28+,29+,30+,31+,32-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m1/s1 ; Key:IYJMSDVSVHDVGT-PEQKVOOWSA-N ;
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