methyldigoxin

メチルジゴキシン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/28 09:59:00」(JST)

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Metildigoxin

Systematic (IUPAC) name
(3β,5β,12β)-3-{[2,6-dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	C
Identifiers
CAS Number	30685-43-9
ATC code	C01AA08
PubChem	CID 443946
ChemSpider	392000 Y
UNII	I7GG1YUC5V Y
Synonyms	4-[(3S,5R,8R,9S,10S,12R,13S,14S)-12,14-Dihydroxy-3-[(2R,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-methoxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Chemical data
Formula	C42H66O14
Molar mass	794.965
SMILES O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](OC)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
InChI InChI=1S/C42H66O14/c1-20-37(49-6)29(43)16-35(51-20)55-39-22(3)53-36(18-31(39)45)56-38-21(2)52-34(17-30(38)44)54-25-9-11-40(4)24(14-25)7-8-27-28(40)15-32(46)41(5)26(10-12-42(27,41)48)23-13-33(47)50-19-23/h13,20-22,24-32,34-39,43-46,48H,7-12,14-19H2,1-6H3/t20-,21-,22-,24-,25+,26-,27-,28+,29+,30+,31+,32-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m1/s1 Y Key:IYJMSDVSVHDVGT-PEQKVOOWSA-N Y
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Metildigoxin (INN, or medigoxin BAN, or methyldigoxin) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). The substance is closely related to digoxin; it differs from the latter only by an O-methyl group on the terminal monosaccharide.

References

English Journal

• Simultaneous analysis of cardiac glycosides in blood and urine by thermoresponsive LC-MS-MS.

• Kanno S1, Watanabe K, Yamagishi I, Hirano S, Minakata K, Gonmori K, Suzuki O.
• Analytical and bioanalytical chemistry.Anal Bioanal Chem.2011 Jan;399(3):1141-9. doi: 10.1007/s00216-010-4405-1. Epub 2010 Nov 15.
• A new thermoresponsive polymer separation column was applied to simultaneous analysis of four cardiac glycosides (CGs) being widely used for the treatment of arrhythmias and heart failure in human blood and urine. This column is composed of an N-isopropylacrylamide polymer, the surface of which unde
• PMID 21076957

• Free and total digoxin in serum during treatment of acute digoxin poisoning with Fab fragments: case study.

• Eyer F1, Steimer W, Müller C, Zilker T.
• American journal of critical care : an official publication, American Association of Critical-Care Nurses.Am J Crit Care.2010 Jul;19(4):391-87. doi: 10.4037/ajcc2009227. Epub 2009 Oct 29.
• A woman ingested 10 mg of methyldigoxin in a suicide attempt and presented 19 hours after ingestion with clinical signs of glycoside intoxication. Her serum level of digoxin was 7.4 ng/mL, and antidotal therapy with Fab antibody fragments was started. The manufacturer's recommended dosing scheme was
• PMID 19875723

• Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.

• Hauck C1, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough AA, Bloch W, Schwinger RH, Müller-Ehmsen J.
• European journal of pharmacology.Eur J Pharmacol.2009 Nov 10;622(1-3):7-14. doi: 10.1016/j.ejphar.2009.08.039. Epub 2009 Sep 12.
• Cardiac glycosides inhibit the Na(+),K(+)-ATPase and are used for the treatment of symptomatic heart failure and atrial fibrillation. In human heart three isoforms of Na(+),K(+)-ATPase are expressed: alpha(1)beta(1), alpha(2)beta(1) and alpha(3)beta(1). It is unknown, if clinically used cardiac glyc
• PMID 19751721

Japanese Journal

• 三尖弁閉鎖不全症犬において右心内圧と血中ＡＮＰならびにＮＴ－ｐｒｏＢＮＰ濃度を測定した１例

• 動物の循環器 42(2), 37-42, 2010
• NAID 130004448860

• 循環器病棟における薬学的支援の取り組み(誌上シンポジウム)

• 藥學雜誌 127(11), 1767-1779, 2007-11-01
• NAID 10020035201

• メチルジゴキシンによる扁平苔癬型薬疹

• 皮膚の科学 6(6), 587-589, 2007
• NAID 130004547260

Related Links

• CiNii 論文 - Effect of Metildigoxin (β-Methyldigoxin) on ...

The efficacy on congestive heart failure of metildigoxin (β-methyldigoxin, MD), a derivative of digoxin (DX), which had a good absorption rate from digestive tract, was examined in a double blind study using a group comparison method.

• CiNii 論文 - Monitoring Serum Free Glycoside Concentration ...

We conducted the present study to obtain basic information about monitoring f-SGC in patients receiving beta-methyldigoxin (BMD), using TDx digoxin assay.<BR>The results showed that accuracy of the f-SGC detected with TDx ...

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metildigoxin, methyldigoxin

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