メジゴキシン
- 関
- metildigoxin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/05/28 11:39:01」(JST)
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Metildigoxin
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy
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ATC code |
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Identifiers |
IUPAC name
- (3β,5β,12β)-3-{[2,6-dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
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Synonyms |
4-[(3S,5R,8R,9S,10S,12R,13S,14S)-12,14-Dihydroxy-3-[(2R,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-methoxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one |
CAS Number |
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PubChem CID |
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ChemSpider |
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UNII |
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ECHA InfoCard |
100.045.705 |
Chemical and physical data |
Formula |
C42H66O14 |
Molar mass |
794.965 |
3D model (Jmol) |
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SMILES
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O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](OC)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
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InChI
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InChI=1S/C42H66O14/c1-20-37(49-6)29(43)16-35(51-20)55-39-22(3)53-36(18-31(39)45)56-38-21(2)52-34(17-30(38)44)54-25-9-11-40(4)24(14-25)7-8-27-28(40)15-32(46)41(5)26(10-12-42(27,41)48)23-13-33(47)50-19-23/h13,20-22,24-32,34-39,43-46,48H,7-12,14-19H2,1-6H3/t20-,21-,22-,24-,25+,26-,27-,28+,29+,30+,31+,32-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m1/s1 Y
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Key:IYJMSDVSVHDVGT-PEQKVOOWSA-N Y
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Metildigoxin (INN, or medigoxin BAN, or methyldigoxin) is a cardiac glycoside,[1] a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). The substance is closely related to digoxin; it differs from the latter only by an O-methyl group on the terminal monosaccharide.
References
- ^ Hayward, R.; Greenwood, H.; Stephens, J.; Hamer, J. (1983). "Relationship between myocardial uptake and actions in heart failure of methyldigoxin". British Journal of Clinical Pharmacology. 15 (1): 41–48. doi:10.1111/j.1365-2125.1983.tb01461.x. PMC 1427830 . PMID 6849743.
Cardiac glycosides (C01A)
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Bufadienolides |
Bufo
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- Arenobufagin
- Bufotalin
- Cinobufagin
- Marinobufagin
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Scilla
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- Proscillaridin
- Scilliroside
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Cardenolides |
Digitalis
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- Acetyldigitoxin
- Acetyldigoxin
- Digitoxin#
- Digoxin#
- Lanatoside C
- Deslanoside
- Metildigoxin
- Gitoformate
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Kalanchoe
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Strophanthus
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- Ouabain (g-Strophanthin)
- k-Strophanthin
- Cymarin
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Thevetia
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Unintentional lethal overdose with metildigoxin in a 36-week-old infant--post mortem tissue distribution of metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry.
- Hess C1, Brockmann C2, Doberentz E2, Madea B2, Musshoff F3.
- Forensic science international.Forensic Sci Int.2014 Aug;241:e23-7. doi: 10.1016/j.forsciint.2014.05.013. Epub 2014 May 24.
- A massive lethal overdose with beta-metildigoxin in a 36-week-old infant is presented. Determination of beta-metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for
- PMID 24889325
- Free and total digoxin in serum during treatment of acute digoxin poisoning with Fab fragments: case study.
- Eyer F1, Steimer W, Müller C, Zilker T.
- American journal of critical care : an official publication, American Association of Critical-Care Nurses.Am J Crit Care.2010 Jul;19(4):391-87. doi: 10.4037/ajcc2009227. Epub 2009 Oct 29.
- A woman ingested 10 mg of methyldigoxin in a suicide attempt and presented 19 hours after ingestion with clinical signs of glycoside intoxication. Her serum level of digoxin was 7.4 ng/mL, and antidotal therapy with Fab antibody fragments was started. The manufacturer's recommended dosing scheme was
- PMID 19875723
- Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system.
- Balenovic D1, Bencic ML, Udovicic M, Simonji K, Hanzevacki JS, Barisic I, Kranjcevic S, Prkacin I, Coric V, Brcic L, Coric M, Brcic I, Borovic S, Radic B, Drmic D, Vrcic H, Seiwerth S, Sikiric P.
- Regulatory peptides.Regul Pept.2009 Aug 7;156(1-3):83-9. doi: 10.1016/j.regpep.2009.05.008. Epub 2009 May 22.
- Pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419) reversed congestive heart failure and various arrhythmias, influenced the NO-system and showed no proarrhythmic effect. In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and
- PMID 19465062
Japanese Journal
- Comparison of digoxin and medigoxin in normal subjects
Related Links
- メジゴキシン (Medigoxin) を Google Scholar, Entrez, Google, Wikipedia で検索 同義語(異表記): ・4'''-O-Methyldigoxin ・Bemecor ・beta-Methyldigoxin ・Lanirapid ・Lanitop ・Medixin ・Methyldigoxin ・Metildigoxin ・メチルジゴキシン ...
- "Medigoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged ... A semisynthetic digitalis glycoside with the general properties of ...
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- 英
- medigoxin
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