関: dl-methylephedrine hydrochloride、l-methylephedrine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/07 20:24:05」(JST)

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1. 世界アンチ・ドーピング機構が定めたホルモン製剤以外の禁止薬剤・禁止物質 prohibited non hormonal performance enhancing drugs in sport

English Journal

Simultaneous determination of 12 illicit drugs in whole blood and urine by solid phase extraction and UPLC-MS/MS.

Zhang L1, Wang ZH2, Li H3, Liu Y2, Zhao M2, Jiang Y1, Zhao WS3.Author information 1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.2Procuratoral Technology and Information Research Center, Supreme People's Procuratorate, Beijing 100144, China.3Key Laboratory of Narcotics Assay and Control Technology, Ministry of Public Security, People's of China, Kunming, Yunnan Province 650000, China.AbstractA rapid and sensitive method based on solid phase extraction and ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) for the simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylene-dioxymethamphetamine, N-methyl-1-(3,4-methyl-enedioxyphenyl)-2-butanamine, 3,4-methylenedioxyethylamphetamine, p-methoxymethamphetamine, ephedrine, N-methylephedrine, cathinone, methcathinone, and ketamine in whole blood and urine was developed and validated. Following solid phase extraction, the analytes were separated on ACQUITY UPLC BEH Phenyl column (100mm×2.1mm, 1.7μm) under gradient elution using a mobile phase containing of acetonitrile and 0.3% formic acid in water at a flow rate of 0.4mLmin(-1) and analyzed by a triplequadrupole mass spectrometer in the multiple reaction monitoring (MRM) mode. The proposed method was linear for each analyte with correlation coefficients over 0.99. Recovery validation studies showed accuracy bias below 4.4%. Acceptable precision was also obtained with a relative standard deviation below 8.9%. The sensitivity of the assay was found to be adequate for the quantitation of the illicit drugs in whole blood and urine sample and was higher than reported methods. The present method was proved to be reliable and robust for drug screening in forensic toxicological analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2014 Apr 1;955-956:10-9. doi: 10.1016/j.jchromb.2014.02.007. Epub 2014 Feb 18.
A rapid and sensitive method based on solid phase extraction and ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) for the simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylene-dioxymethampheta
PMID 24631805

Catalytic enantioselective nucleophilic addition of ynamides to aldehydes.

Cook AM1, Wolf C.Author information 1Department of Chemistry, Georgetown University, Washington, DC 20057, USA. cw27@georgetown.edu.AbstractThe first catalytic asymmetric addition of ynamides to aliphatic and aromatic aldehydes is described. This reaction provides unprecedented access to a diverse family of N-substituted propargylic alcohols that are obtained in high yield and ee in the presence of 10 mol% of zinc triflate and N-methylephedrine. The use of apolar solvent mixtures is essential to avoid product racemization and to optimize ee's without compromising conversion.
Chemical communications (Cambridge, England).Chem Commun (Camb).2014 Mar 25;50(24):3151-4. doi: 10.1039/c4cc00394b. Epub 2014 Feb 12.
The first catalytic asymmetric addition of ynamides to aliphatic and aromatic aldehydes is described. This reaction provides unprecedented access to a diverse family of N-substituted propargylic alcohols that are obtained in high yield and ee in the presence of 10 mol% of zinc triflate and N-methyle
PMID 24519669

A case of levocetirizine-induced fixed drug eruption and cross-reaction with piperazine derivatives.

Kim MY1, Jo EJ, Chang YS, Cho SH, Min KU, Kim SH.Author information 1Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan 614-735, Korea.AbstractFixed drug eruption is an uncommon adverse drug reaction caused by delayed cell-mediated hypersensitivity. Levocetirizine is an active (R)-enatiomer of cetirizine and there have been a few reports of fixed drug eruption related to these antihistamines. We experienced a case of levocetirizine-induced fixed drug eruption and cross-reaction with other piperazine derivatives confirmed by patch test. A 73-year-old female patient presented with recurrent generalized itching, cutaneous bullae formation, rash and multiple pigmentation at fixed sites after taking drugs for common cold. She took bepotastine besilate (Talion®) and levocetirizine (Xyzal®) as antihistamine. She took acetaminophen, pseudoephedrine 60 mg / triprolidine 2.5 mg (Actifed®), dihydrocodeinebitartrate 5 mg / di-methylephedrine hydrochloride 17.5 mg / chlorpheniramine maleate 1.5 mg / guaifenesin 50 mg (Codening®) and aluminium hydroxide 200 mg / magnesium carbonate 120 mg (Antad®) at the same time. Patch test was done with suspected drugs and the result was positive with levocetirizine. We additionally performed patch test for other antihistamines such as cetirizine, hydroxyzine, fexofenadine and loratadine. Piperazine derivatives (cetirizine and hydroxyzine) were positive, but piperidine derivatives (fexofenadine and loratadine) were negative to patch test. There was no adverse drug reaction when she was challenged with fexofenadine. We report a case of levocetirizine-induced fixed drug eruption confirmed by patch test. Cross-reactions were only observed in the piperazine derivatives and piperidine antihistamine was tolerant to the patient.
Asia Pacific allergy.Asia Pac Allergy.2013 Oct;3(4):281-4. doi: 10.5415/apallergy.2013.3.4.281. Epub 2013 Oct 31.
Fixed drug eruption is an uncommon adverse drug reaction caused by delayed cell-mediated hypersensitivity. Levocetirizine is an active (R)-enatiomer of cetirizine and there have been a few reports of fixed drug eruption related to these antihistamines. We experienced a case of levocetirizine-induced
PMID 24260733

Japanese Journal

思春期におけるブロン乱用患者の1例 (医学部精神医学講座石郷岡純教授退任記念特別号)

東京女子医科大学雑誌 = Journal of Tokyo Women's Medical University 86(臨増1), E150-153, 2016-01
NAID 40020782134

Ischemic Stroke Associated with Cough and Cold Preparation Containing Methylephedrine and Supplement Containing Chinese Herbal Drugs

Internal Medicine 49(4), 335-338, 2010
NAID 130000152619

Intoxication with Over-the-Counter Antitussive Medication Containing Dihydrocodeine and Chlorpheniramine Causes Generalized Convulsion and Mixed Acidosis

Internal Medicine 47(11), 1013-1015, 2008
NAID 130000078659

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