WordNet
- bruise, cut, or injure the skin or the surface of; "The boy skinned his knee when he fell" (同)scrape
- a persons skin regarded as their life; "he tried to save his skin"
- a bag serving as a container for liquids; it is made from the hide of an animal
- an outer surface (usually thin); "the skin of an airplane"
- a natural protective body covering and site of the sense of touch; "your skin is the largest organ of your body" (同)tegument, cutis
- strip the skin off; "pare apples" (同)peel, pare
- an impairment of health or a condition of abnormal functioning
- move along on skis; "We love to ski the Rockies"; "My children dont ski"
- narrow wood or metal or plastic runners used in pairs for gliding over snow
- of or relating to metabolism; "metabolic rate"
- undergoing metamorphosis (同)metabolous
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
PrepTutorEJDIC
- 〈U〉〈C〉(人・動物の)『皮膚』,肌 / 〈C〉〈U〉(動物からはいだ)『皮』,『毛皮』;皮製品,皮袋 / 〈C〉(果物・野菜の)皮 / 〈U〉〈C〉(液体の表面にできる)薄い膜,上皮 / 〈C〉(枠組み・表面などを覆う)外皮,外被,外板 / 〈動物・果物など〉‘の'皮をはぐ(むく) / 〈手・脚など〉‘を'擦りむく / 《話》(金などを)〈人〉‘から'巻き上げる《+『名』〈人〉+『of』+『名』》 / 〈傷口などが〉皮で覆われる《+『over』》
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 『スキー』 / 『スキーで滑走する』 / …‘を'スキーで滑る / スキーの,スキー用の
- 新陳代謝の
- 病気にかかった / 病的な,不健全な(morbid)
UpToDate Contents
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- 1. 膿疱性皮膚病変を有する患者へのアプローチ approach to the patient with pustular skin lesions
- 2. 免疫能の正常な患者における発熱および発疹 fever and rash in the immunocompetent patient
- 3. 顔面紅斑が認められる患者に対するアプローチ approach to the patient with facial erythema
- 4. 斑状の皮膚病変を有する患者へのアプローチ approach to the patient with macular skin lesions
- 5. 好中球性皮膚症 neutrophilic dermatoses
English Journal
- Detection of oxidized and glycated proteins in clinical samples using mass spectrometry - A user's perspective.
- Thornalley PJ, Rabbani N.Author information Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK; Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, UK. Electronic address: P.J.Thornalley@warwick.ac.uk.AbstractBACKGROUND: Proteins in human tissues and body fluids continually undergo spontaneous oxidation and glycation reactions forming low levels of oxidation and glycation adduct residues. Proteolysis of oxidised and glycated proteins releases oxidised and glycated amino acids which, if they cannot be repaired, are excreted in urine.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Feb;1840(2):818-29. doi: 10.1016/j.bbagen.2013.03.025. Epub 2013 Apr 2.
- BACKGROUND: Proteins in human tissues and body fluids continually undergo spontaneous oxidation and glycation reactions forming low levels of oxidation and glycation adduct residues. Proteolysis of oxidised and glycated proteins releases oxidised and glycated amino acids which, if they cannot be rep
- PMID 23558060
- Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer.
- Ciunci CA, Perini RF, Avadhani AN, Kang HC, Sun W, Redlinger M, Harlacker K, Flaherty KT, Giantonio BJ, Rosen MA, Divgi CR, Song HK, Englander S, Troxel A, Schnall M, O'Dwyer PJ.Author information Abramson Cancer Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.AbstractBACKGROUND: Preclinical and clinical studies suggest mTOR (mammalian target of rapamycin) inhibitors may have metabolic and antiangiogenic effects, and synergize with epidermal growth factor pathway inhibitors. Therefore, a phase 1/pharmacodynamic trial of everolimus with cetuximab was performed.
- Cancer.Cancer.2014 Jan 1;120(1):77-85. doi: 10.1002/cncr.28294. Epub 2013 Sep 24.
- BACKGROUND: Preclinical and clinical studies suggest mTOR (mammalian target of rapamycin) inhibitors may have metabolic and antiangiogenic effects, and synergize with epidermal growth factor pathway inhibitors. Therefore, a phase 1/pharmacodynamic trial of everolimus with cetuximab was performed.MET
- PMID 24108668
- Glucosepane: a poorly understood advanced glycation end product of growing importance for diabetes and its complications.
- Monnier VM, Sun W, Sell DR, Fan X, Nemet I, Genuth S.AbstractAbstract Advanced glycation end products (AGEs) represent a family of protein, peptide, amino acid, nucleic acid and lipid adducts formed by the reaction of carbonyl compounds derived directly or indirectly from glucose, ascorbic acid and other metabolites such as methylglyoxal. AGE formation in diabetes is of growing importance for their role as markers and potential culprits of diabetic complications, in particular retinopathy, nephropathy and neuropathy. Development of sensitive and specific assays utilizing liquid chromatography mass spectrometry with isotope dilution method has made it possible to detect and quantitate non-UV active AGEs such as carboxymethyl-lysine and glucosepane, the most prevalent AGE and protein crosslink of the extracellular matrix. Below we review studies on AGE formation in two skin biopsies obtained near the closeout of the Diabetes Control and Complications Trial (DCCT), one of which was processed in 2011 for assay of novel AGEs. The results of these analyses show that while several AGEs are associated and predict complication progression, the glucose/fructose-lysine/glucosepane AGE axis is one of the most robust markers for microvascular disease, especially retinopathy, in spite of adjustment for past or future average glycemia. Yet overall little biological and clinical information is available on glucosepane, making this review a call for data in a field of growing importance for diabetes and chronic metabolic diseases of aging.
- Clinical chemistry and laboratory medicine : CCLM / FESCC.Clin Chem Lab Med.2014 Jan 1;52(1):21-32. doi: 10.1515/cclm-2013-0174.
- Abstract Advanced glycation end products (AGEs) represent a family of protein, peptide, amino acid, nucleic acid and lipid adducts formed by the reaction of carbonyl compounds derived directly or indirectly from glucose, ascorbic acid and other metabolites such as methylglyoxal. AGE formation in dia
- PMID 23787467
Japanese Journal
- Liver X Receptor: A Cardinal Target for Atherosclerosis and Beyond
- Journal of Atherosclerosis and Thrombosis 21(6), 519-531, 2014
- NAID 130004444743
- Metabolic Risk Factors Are Associated With Stiffness Index, Reflection Index and Finger Skin Temperature in Children : Physical Activity and Nutrition in Children (PANIC) Study
- Circulation journal : official journal of the Japanese Circulation Society 77(5), 1281-1288, 2013-04-25
- NAID 10031151392
- 非アルコール性脂肪性肝炎モデルマウスにおける、慢性細菌曝露が誘因となる遠隔部皮膚病変の検討
- 東京女子医科大学雑誌 81(2), 102-110, 2011-04-25
- NAID 110008462587
Related Links
- Metabolic aspects of skin disease. J Marks. Full text. Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (534K), or click on a page image below to browse page by page.
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★リンクテーブル★
| リンク元 | 「代謝性皮膚疾患」 |
| 関連記事 | 「disease」「metabolic」「skin disease」「skin」 |
「代謝性皮膚疾患」
「disease」
- n.
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 注意
「metabolic」
- adj.
- 代謝性の、代謝的な、メタボリックな
「skin disease」
「skin」
- n.