WordNet
- any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs
PrepTutorEJDIC
- 〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/02 15:20:14」(JST)
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Mepenzolate
|
Systematic (IUPAC) name |
3-(2-hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidinium |
Clinical data |
AHFS/Drugs.com |
Consumer Drug Information |
Legal status |
? |
Identifiers |
CAS number |
25990-43-6 Y |
ATC code |
A03AB12 |
PubChem |
CID 4057 |
ChemSpider |
3917 N |
UNII |
ONW3LB39P7 N |
ChEMBL |
CHEMBL524004 N |
Chemical data |
Formula |
C21H26NO3+ |
Mol. mass |
340.44 g/mol |
N (what is this?) (verify) |
Mepenzolate is an antimuscarinic.[1]
References
- ^ Tsai, C. S.; Guede-Guina, F.; Smith, M. O.; Vangah-Manda, M.; Ochillo, R. F. (1995). "Isolation of cholinergic active ingredients in aqueous extracts of Mareya micrantha using the longitudinal muscle of isolated guinea-pig ileum as a pharmacological activity marker". Journal of Ethnopharmacology 45 (3): 215–222. doi:10.1016/0378-8741(94)01219-P. PMID 7623487. edit
Drugs for functional gastrointestinal disorders (A03)
|
|
Drugs for
functional
bowel disorders |
Antimuscarinics
|
Tertiary
amino group
|
- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
|
Quaternary
ammonium
compounds
|
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
|
|
|
Phosphodiesterase
inhibitors
|
- Papaverine
- Drotaverine
- Moxaverine
|
|
Acting on
serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
|
|
|
Belladonna
and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
|
|
Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
|
|
|
anat (t, g, p)/phys/devp/enzy
|
noco/cong/tumr, sysi/epon
|
proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
|
|
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UpToDate Contents
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English Journal
- Muscarinic cholinergic receptors in human narcolepsy: a PET study.
- Sudo Y, Suhara T, Honda Y, Nakajima T, Okubo Y, Suzuki K, Nakashima Y, Yoshikawa K, Okauchi T, Sasaki Y, Matsushita M.SourceDivision of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan. sudo_y@nirs.go.jp
- Neurology.Neurology.1998 Nov;51(5):1297-302.
- OBJECTIVES: To investigate the function of the muscarinic cholinergic receptor (mAchR) in narcolepsy and the effects of pharmacotherapy on mAchRs.BACKGROUND: Muscarinic neural transmission serves as the main executive system in REM sleep. Studies in canine narcolepsy reported an increase in mAchRs i
- PMID 9818849
- Isolation of cholinergic active ingredients in aqueous extracts of Mareya micrantha using the longitudinal muscle of isolated guinea-pig ileum as a pharmacological activity marker.
- Tsai CS, Guede-Guina F, Smith MO, Vangah-Manda M, Ochillo RF.SourceLaboratories of Pharmacology and Toxicology, Xavier University of Louisiana, New Orleans 70125, USA.
- Journal of ethnopharmacology.J Ethnopharmacol.1995 Mar;45(3):215-22.
- In our attempt to isolate the pharmacologically active ingredients in the aqueous extracts of Mareya micrantha, we have selected the contractions of the longitudinal muscle of the isolated guinea-pig ileum preparation as a pharmacological marker to monitor retention of pharmacological activity durin
- PMID 7623487
Japanese Journal
- Tiemonium iodideのイヌ生体位結腸運動に及ぼす影響
- 岡田 謙司,今井 浩達,外川 芳子,野崎 正勝,鶴見 介登,藤村 一,長岡 俊治
- 日本薬理学雑誌 80(6), 495-503, 1982
- … iodide(tiemonium,20μg/kg i.v.)のイヌ生体位結腸運動に及ぼす効果をmepenzolate bromide(mepenzolate,20μg/kg i.v.),butylscopolamine bromide(butylscopolamine,50μg/kg i.v.)およびatropine sulfate(atropine,10μg/kg i.v.)と比較検討した.バルーン法で得た結腸運動波形を高速フーリエ変により解析し,またパワースペクトルの第1項値をtonus indexとして腸管緊張の指標とした.結腸正常運動 …
- NAID 130000760447
- 便通異常とくに下痢症に対するMepenzolate bromide錠の使用経験
Related Links
- Mepenzolate Bromide professional patient advice. Specific and up to date information about Mepenzolate Bromide.
- 19 Sep 2001 ... Mepenzolate Bromide Drug Information from Drugs.com. Includes Mepenzolate Bromide side effects, interactions and indications.
Related Pictures
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- 臭化メペンゾラート mepenzolate bromide
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