WordNet

any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/02 15:20:14」(JST)

Mepenzolate is an antimuscarinic.^[1]

^ Tsai, C. S.; Guede-Guina, F.; Smith, M. O.; Vangah-Manda, M.; Ochillo, R. F. (1995). "Isolation of cholinergic active ingredients in aqueous extracts of Mareya micrantha using the longitudinal muscle of isolated guinea-pig ileum as a pharmacological activity marker". Journal of Ethnopharmacology 45 (3): 215–222. doi:10.1016/0378-8741(94)01219-P. PMID 7623487. edit

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Sudo Y, Suhara T, Honda Y, Nakajima T, Okubo Y, Suzuki K, Nakashima Y, Yoshikawa K, Okauchi T, Sasaki Y, Matsushita M.SourceDivision of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan. sudo_y@nirs.go.jp
Neurology.Neurology.1998 Nov;51(5):1297-302.
OBJECTIVES: To investigate the function of the muscarinic cholinergic receptor (mAchR) in narcolepsy and the effects of pharmacotherapy on mAchRs.BACKGROUND: Muscarinic neural transmission serves as the main executive system in REM sleep. Studies in canine narcolepsy reported an increase in mAchRs i
PMID 9818849

Isolation of cholinergic active ingredients in aqueous extracts of Mareya micrantha using the longitudinal muscle of isolated guinea-pig ileum as a pharmacological activity marker.

Tsai CS, Guede-Guina F, Smith MO, Vangah-Manda M, Ochillo RF.SourceLaboratories of Pharmacology and Toxicology, Xavier University of Louisiana, New Orleans 70125, USA.
Journal of ethnopharmacology.J Ethnopharmacol.1995 Mar;45(3):215-22.
In our attempt to isolate the pharmacologically active ingredients in the aqueous extracts of Mareya micrantha, we have selected the contractions of the longitudinal muscle of the isolated guinea-pig ileum preparation as a pharmacological marker to monitor retention of pharmacological activity durin
PMID 7623487

岡田謙司,今井浩達,外川芳子,野崎正勝,鶴見介登,藤村一,長岡俊治
日本薬理学雑誌 80(6), 495-503, 1982
… iodide(tiemonium，20μg/kg i.v.)のイヌ生体位結腸運動に及ぼす効果をmepenzolate bromide(mepenzolate，20μg/kg i.v.)，butylscopolamine bromide(butylscopolamine，50μg/kg i.v.)およびatropine sulfate(atropine，10μg/kg i.v.)と比較検討した．バルーン法で得た結腸運動波形を高速フーリエ変により解析し，またパワースペクトルの第1項値をtonus indexとして腸管緊張の指標とした．結腸正常運動 …
NAID 130000760447

Mepenzolate
Systematic (IUPAC) name
	3-(2-hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidinium
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Legal status	?
Identifiers
CAS number	25990-43-6
ATC code	A03AB12
PubChem	CID 4057
ChemSpider	3917
UNII	ONW3LB39P7
ChEMBL	CHEMBL524004
Chemical data
Formula	C21H26NO3+
Mol. mass	340.44 g/mol
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