Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/11 14:24:04」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

  • Two different formulations with equivalent effect? Comparison of serum estradiol suppression with monthly goserelin and trimonthly leuprolide in breast cancer patients.
  • Aydiner A, Kilic L, Yildiz I, Keskin S, Sen F, Kucucuk S, Karanlik H, Muslumanoglu M, Igci A.SourceDepartment of Medical Oncology, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey, adnanaydiner@superonline.com.
  • Medical oncology (Northwood, London, England).Med Oncol.2013 Mar;30(1):354. doi: 10.1007/s12032-012-0354-1. Epub 2012 Dec 29.
  • Data comparing the efficacy of monthly and trimonthly formulations of LHRH agonists are lacking. The aim of this study was to compare the effects of monthly goserelin and trimonthly leuprolide on estradiol levels. A total of 79 early breast cancer patients receiving LHRH agonists for at least 6 mon
  • PMID 23275115
  • Testosterone modulation of anxiety in gonadally-suppressed male rhesus monkeys: A role for gonadotropins?
  • Suarez-Jimenez B, Gore HE, Hachey J, King HM, Lacreuse A.SourceDepartment of Psychology, University of Massachusetts, Amherst MA, USA; Postbaccalaureate Research Education Program, University of Massachusetts, Amherst MA, USA; National Institutes of Health, National Institute on Mental Health, Bethesda MD, USA.
  • Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2013 Jan 16. pii: S0091-3057(13)00008-7. doi: 10.1016/j.pbb.2013.01.004. [Epub ahead of print]
  • Testosterone (T) has repeatedly been shown to have anxiolytic properties in rodents, but findings in primates are more mixed. To examine the effects of exogenous T on anxiety, we tested pharmacologically-castrated adult male rhesus monkeys in a modified version of the Human Intruder Paradigm, which
  • PMID 23333155
  • Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls.
  • Hernández MI, Martínez-Aguayo A, Cavada G, Peña V, Trejo L, Avila A, Salazar T, Asenjo S, Iñiguez G, Rey R, Mericq V.AbstractAbstract Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical exam, bone age, pelvic ultrasound, and measurement of gonadal hormones using a leuprolide test. Results: Forty-one girls (AGA 25/LBW 16) were followed up for 3 years. By 3 years, they had similar bone age, adjusted height, and body composition. In LBW girls, breast Tanner stage advanced faster during the first 2 years of follow-up, which was associated with higher serum androgens. Hirsutism score, ovarian volume, and number of follicles between AGA and LBW were not different nor was age of menarche. By the third year, basal and poststimulated levels of gonadotropins and androgens anti-Müllerian hormone and inhibin B were similar in both groups and did not show differences related to birth weight or degree of catch-up growth. Conclusion: LBW recruits showed a slightly faster breast development but no differences in androgen excess signs, internal genitalia, and gonadal hormonal patterns.
  • Journal of pediatric endocrinology & metabolism : JPEM.J Pediatr Endocrinol Metab.2013 Jan 12:1-8. doi: 10.1515/jpem-2012-0345. [Epub ahead of print]
  • Abstract Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical
  • PMID 23314525

Japanese Journal

  • 酢酸リュープロレリン皮下注射による皮下硬結形成の検討
  • 福井 真二,中井 靖,松本 吉弘 [他],影林 頼明,三馬 省二
  • 泌尿器科紀要 = Acta urologica Japonica 61(2), 55-59, 2015-02
  • … We investigated the incidence of granuloma and its related factors in 180 patients with prostate cancer who showed subcutaneous granuloma formation during androgen deprivation therapy with subcutaneously administered leuprorelin acetate. … Among the 180 patients with prostate cancer, 21 (11.7%) developed a granuloma at the injection portion, and subsequently the injection of leuprorelin acetate had to be discontinued. …
  • NAID 120005575175
  • 酢酸リュープロレリン(3カ月持続徐放性製剤)皮下注射による異物肉芽腫の1例 (特集 薬疹・薬物障害・中毒疹)
  • 伊藤 倫子,飯島 茂子
  • 皮膚科の臨床 56(10), 1439-1444, 2014-10
  • NAID 40020232778
  • 症例 リュープロレリン酢酸塩3カ月製剤皮下注射により生じた肉芽腫 : 肉芽腫切除と前立腺特異抗原(PSA)について
  • 園部 博子,奥田 浩人,荒井 利恵
  • 皮膚科の臨床 56(6), 881-884, 2014-06
  • NAID 40020124272

Related Links

Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl). Contents. 1 Mode of action; 2 Clinical use; 3 Lupron protocol; 4 Approvals; 5 Warnings ...
Leuprorelin (leuprolide acetate) is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex ... With continued use, leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed ...

Related Pictures

LeuprorelinFile:Leuprorelin.svg - Wikipedia, the free CAS # 53714-56-0, LeuprorelinLeuprorelin (leuprorelide) breast and Leuprorelin - Wikipedia, the free Leuprorelin Acetate




酢酸リュープロレリン leuprorelin acetate



  • 連続投与による下垂体前葉-性腺系の抑制


  • 前立癌:血清テストステロン濃度の抑制
  • 子宮内膜症、閉経前乳癌、中枢思春期早発症




  • (成人)リュープロレリン酢酸塩3.75mg皮下注。4週毎。 (体重50kg未満)リュープロレリン酢酸塩1.88mg皮下注。4週毎。なお、初回投与は月経周期1~5日目に行う。


  • (成人)リュープロレリン酢酸塩1.88mg皮下注。4週毎。 (体重が重い、子宮高度腫大)リュープロレリン酢酸塩3.75mg皮下注。4週毎。 なお、初回投与は月経周期1~5日目に行う。


  • (成人)リュープロレリン酢酸塩3.75mg皮下注。4週毎。


  • リュープロレリン酢酸塩30μg/kg皮下注。4週毎。180μg/kgまで増量可


  • リュープロレリン酢酸塩11.25mg皮下注。12週毎。





リュープロレリン leuprorelinロイプロリド leuprolide
  • 商品名
  • LH-RH作動薬;前立腺癌および閉経前乳癌治療;子宮内膜症治療
  • 日本での販売なし?