leiomyoma

平滑筋腫

　

WordNet

1. benign tumor of smooth muscle (usually in the uterus or digestive tract)
2. a benign tumor composed of muscle tissue

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/27 11:37:44」(JST)

wiki en

[Wiki en表示]

Leiomyoma
Uterine lipoleiomyoma, a type of leiomyoma. H&E stain.
Classification and external resources
ICD-10	D21, D25 (ILDS D21.M40)
ICD-9-CM	218
ICD-O	M8890/0-8894
MedlinePlus	dostinex
MeSH	D007889

A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, "smooth-muscle tumor") is a benign smooth muscle neoplasm that very rarely becomes cancer (0.1%). They can occur in any organ, but the most common forms occur in the uterus, small bowel, and the esophagus.

Leiomyoma enucleated from a uterus. External surface on left; cut surface on right

Uterus

Main article: Uterine fibroids

Uterine fibroids are leiomyomata of the uterine smooth muscle. As other leiomyomata, they are benign, but may lead to excessive menstrual bleeding (menorrhagia), often cause anemia and may lead to infertility.

A rare form of these tumors is uterine lipoleiomyoma - benign tumors consisting of a mixture of adipocytes and smooth muscle cells. Uterine lipoleiomyomata have been observed together with ovarian and other pathologies and some of them may develop into liposarcoma. These tumors are monoclonal, and non-random chromosomal abnormalities have been seen in 40% of the tumors.

Gallbladder

Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, all of them in patients with immune system disorders. Although, recently, a case was reported in absence of associated immunodeficiency.

Skin

Leiomyomas of the skin are generally (1) acquired, and (2) divided into several categories:

• Solitary cutaneous leiomyoma
• Multiple cutaneous (or pilar) leiomyomas arising from the arrectores pilorum muscles
• Angioleiomyomas (Vascular leiomyomas) that are thought to arise from vascular smooth muscle
• Dartoic (or genital) leiomyomas originating in the dartos muscles of the genitalia, areola, and nipple
• Angiolipoleiomyoma

Small intestines

Leiomyoma is the most common benign tumor of small bowel. Approximately 50% of cases are found in the jejunum, followed by the ileum in 31% of cases. Almost one half of all lesions are less than 5 centimeters.

Other locations, metastatic leiomyoma

• Metastatic leiomyoma are an extremely rare complication after surgery to remove the uterus for uterine fibroids. The most frequent sites of occurrence are the lungs and pelvis. The lesions are hormonally responsive.
• Fibromyoma of the breast is an extremely rare benign breast neoplasm. Most reports in literature mention a history of hysterectomy for uterine fibroids, although the question of whether these fibromyomas are possibly metastases of the uterine fibroids has not been investigated. An alternative hypothesis is an origin from the smooth muscle of the nipple.

Familial leiomyoma

• Associated with papillary variant of renal cell carcinoma and multiple cutaneous leiomyoma. Defect is in the fumarate hydratase gene in the long arm of chromosome 1.

See also

• Leiomyosarcoma

References

External links

• humpath #4835 (Pathology images)
• Laser myomectomy
• Laparoscopic myomectomy.
• Uterine fibroids at Merck Manual of Diagnosis and Therapy Professional Edition
• Esophageal Leiomyoma at eMedicine
• Atlas of Pathology uterine leimyoma

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 子宮平滑筋腫（子宮筋腫）の疫学、臨床症状、診断、および自然経過 epidemiology clinical manifestations diagnosis and natural history of uterine leiomyomas fibroids
• 2. 子宮平滑筋腫（子宮筋腫）の治療の概要 overview of treatment of uterine leiomyomas fibroids
• 3. 消化管間質腫瘍、平滑筋腫、および消化管の平滑筋肉腫の局所治療 local treatment for gastrointestinal stromal tumors leiomyomas and leiomyosarcomas of the gastrointestinal tract
• 4. 子宮筋腫と子宮肉腫の識別 differentiating uterine leiomyomas fibroids from uterine sarcomas
• 5. 子宮平滑筋腫（子宮筋腫）の組織学的検査および病因 histology and pathogenesis of uterine leiomyomas fibroids

English Journal

• Two Subtypes of Atypical Leiomyoma: Clinical, Histologic, and Molecular Analysis.

• Ubago JM1, Zhang Q, Kim JJ, Kong B, Wei JJ.
• The American journal of surgical pathology.Am J Surg Pathol.2016 Jul;40(7):923-33. doi: 10.1097/PAS.0000000000000646.
• Atypical leiomyoma (ALM) is a rare variant of uterine smooth muscle tumors. Several recent studies have suggested that ALM has distinct, but also heterogenous, histologic and molecular features, yet little is known about the biology and histogenesis of ALM. Some have even postulated whether the atyp
• PMID 27015034

• IV Leiomyomatosis on FDG PET/CT.

• Jin X1, Li F, Lu Z, Cheng W.
• Clinical nuclear medicine.Clin Nucl Med.2016 Jul;41(7):580-2. doi: 10.1097/RLU.0000000000001185.
• A 48-year-old woman presented with a 2-month history of right lower extremity edema. Clinical examination only showed right lower limb swelling. Routine laboratory examination revealed no abnormal results. Abdominal ultrasonography identified uterine leiomyoma and soft tissue masses. An abdominal CT
• PMID 26914578

• Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model.

• Koohestani F1, Qiang W2, MacNeill AL3, Druschitz SA4, Serna VA5, Adur M6, Kurita T5, Nowak RA7.
• Human reproduction (Oxford, England).Hum Reprod.2016 Jul;31(7):1540-51. doi: 10.1093/humrep/dew094. Epub 2016 Apr 29.
• STUDY QUESTION: Does halofuginone (HF) inhibit the growth of human uterine leiomyoma cells in a mouse xenograft model SUMMARY ANSWER: HF suppresses the growth of human uterine leiomyoma cells in a mouse xenograft model through inhibiting cell proliferation and inducing apoptosis.WHAT IS KNOWN ALREAD
• PMID 27130615

Japanese Journal

• 反復する閉塞性肺炎にて発見された気管支良性転移性平滑筋腫の1例

• 清水 陽介,伊藤 祥隆,高瀬 恵一郎,小嶋 徹,中屋 順哉,山口 航
• 気管支学 : 日本気管支研究会雑誌 34(6), 611-615, 2012-11-25
• 背景.良性転移性平滑筋腫は,良性の子宮平滑筋腫が他臓器に転移をきたす稀な病態である.症例. 37歳,女性. 33歳時に子宮筋腫摘出術の既往がある.半年前に右下葉の肺炎にて近医で入院加療された.今回,咳嗽と発熱を主訴に近医を受診,精査加療目的に当院紹介となった.精査にて右下葉B^<10>_bをほぼ閉塞する腫瘍による閉塞性肺炎と診断,腫瘍は生検にて平滑筋腫と診断した.抗菌薬治療による炎症の …
• NAID 110009562570

• 症例 胆平滑筋腫の1例

• 中川 国利,深町 伸,生澤 史江 [他]
• 外科 74(11), 1249-1252, 2012-11-00
• NAID 40019471319

• 症例報告 傍尿道平滑筋腫の1例

• 永吉 陽子,上田 和,佐々木 香苗 [他]
• 東京産科婦人科学会会誌 61(3), 383-386, 2012-10-00
• NAID 40019492575

Related Links

• 平滑筋腫とは - www.ne.jp

平滑筋腫とは About Leiomyoma 筋肉は随意筋である横紋筋と不随意筋である平滑筋に大きく分けられます。 平滑筋は、血管や消化管を構成する筋層で、消化管の場合食べ物を腸の中へ運ぶ働きをします。 この筋層から発生する腫瘍を平滑 ...

• Leiomyomaとは - goo Wikipedia (ウィキペディア)

Leiomyomaとは？goo Wikipedia (ウィキペディア) 。出典：Wikipedia（ウィキペディア）フリー百科事典。 Leiomyomaとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ メール ...

Related Pictures

---

★リンクテーブル★

リンク元	「平滑筋腫」「uterine fibroid」「fibroid tumor」「leio」「筋腫」
拡張検索	「uterine leiomyoma」「lymphangioleiomyoma」「pulmonary lymphangioleiomyomatosis」

「平滑筋腫」

　　[★]

leio

英

leiomyoma

同

筋腫 myoma

関

平滑筋肉腫 leiomyosarcoma

概念

• 平滑筋細胞に由来する良性腫瘍

予防

-leiomyoma

「uterine fibroid」

　　[★]

子宮筋腫、子宮類線維症

関

fibroid、fibroid tumor、hysteromyoma、leiomyoma、uterine leiomyoma

「fibroid tumor」

　　[★]

• 類線維腫

関

desmoid、fibroid、leiomyoma、uterine fibroid

「leio」

　　[★]

• comb form

• なめらかな、平滑な

• ex.

• leiomyoma 平滑筋腫

「筋腫」

　　[★]

英

myoma、leiomyoma

関

平滑筋腫

「uterine leiomyoma」

　　[★]

子宮筋腫、子宮平滑筋腫

関

fibroid、hysteromyoma、uterine fibroid

「lymphangioleiomyoma」

　　[★]

リンパ脈管筋腫

関

lymphangiomyoma

「pulmonary lymphangioleiomyomatosis」

　　[★] 肺リンパ脈管筋腫症