WordNet

the grammatical relation that exists when a word qualifies the meaning of the phrase (同)qualifying, limiting
slightly modified copy; not an exact copy; "a modification of last years model"
incapable of being reversed; "irreversible momentum toward revolution"
of or relating to or characterized by covalence; "covalent bond"

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1. 成人における赤血球輸血：保管、専門的調整、および輸血パラメータ red blood cell transfusion in adults storage specialized modifications and infusion parameters
2. 肺腫瘍の画像ガイド下焼灼術 image guided ablation of lung tumors
3. ゴーシェ病：治療 gaucher disease treatment
4. 抗レトロウイルス剤投与患者における悪性腫瘍に対する全身療法 systemic therapy for malignancy in patients on anti retroviral medications
5. 咽喉頭逆流 laryngopharyngeal reflux

Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.

Mukherjee S1, Weiner WS, Schroeder CE, Simpson DS, Hanson AM, Sweeney NL, Marvin RK, Ndjomou J, Kolli R, Isailovic D, Schoenen FJ, Frick DN.
ACS chemical biology.ACS Chem Biol.2014 Oct 17;9(10):2393-403. doi: 10.1021/cb500512z. Epub 2014 Aug 15.
The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is both a protease, which cleaves viral and host proteins, and a helicase that separates nucleic acid strands, using ATP hydrolysis to fuel the reaction. Many antiviral drugs, and compounds in clinical trials, target the NS3 protease, but few
PMID 25126694

Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.

Taldone T1, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G.
Journal of medicinal chemistry.J Med Chem.2014 Feb 27;57(4):1208-24. doi: 10.1021/jm401552y. Epub 2014 Feb 18.
The discovery and development of heat shock protein 70 (Hsp70) inhibitors is currently a hot topic in cancer. In the preceding paper in this issue ( 10.1021/jm401551n ), we have described structure-activity relationship studies in the first Hsp70 inhibitor class rationally designed to bind to a nove
PMID 24548239

王子田彰夫,宮原芳文,浜地格
有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 64(2), 141-150, 2006-02-01
… On the other hand, covalent bond formation of protein with a small molecule has also been recognized as a powerful strategy to regulate protein functions, and enormous efforts have been devoted to develop selective irreversible inhibitors for proteins, especially for the families of proteases, in the research field of medicinal chemistry. … We also provide an overview of the irreversible inhibitors, including their recent advancements and some applications for proteome analysis or drug discovery. …
NAID 10017252385